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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5c7hNDPPutative oxidoreductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5c7hNDPPutative oxidoreductase/1.000
4pmjNAPPutative oxidoreductase/0.692
3h7rNAPAldo-keto reductase family 4 member C8/0.494
2hdjNDPAldo-keto reductase family 1 member C2/0.491
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.485
1ah4NAPAldose reductase1.1.1.210.477
1adsNAPAldose reductase1.1.1.210.475
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.474
4l1xNAPAldo-keto reductase family 1 member C2/0.474
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.473
4xo7NAPAldo-keto reductase family 1 member C2/0.468
4jq3NAPAldo-keto reductase family 1 member C2/0.467
1c9wNAPAldose reductase-related protein 2/0.463
2pf8NDPAldose reductase1.1.1.210.463
2pfhNDPAldose reductase1.1.1.210.462
4dz5NAPAldo-keto reductase family 1 member C3/0.462
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.460
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.459
1zgdNAPChalcone reductase/0.459
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
4jtqNAPAldo-keto reductase family 1 member C2/0.459
1vp5NAPOxidoreductase, aldo/keto reductase family/0.458
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.458
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.455
1z8aNAPAldose reductase1.1.1.210.454
1x98NAPAldose reductase1.1.1.210.453
2pevNDPAldose reductase1.1.1.210.453
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.451
4g5dNDPProstaglandin F synthase1.1.1.1880.451
2j8tNAPAldose reductase1.1.1.210.450
2hejNDPAldo-keto reductase family 1 member C211.1.10.449
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.448
1x96NAPAldose reductase1.1.1.210.448
2acqNAPAldose reductase1.1.1.210.446
2vdgNDPAldose reductase1.1.1.210.446
1az2NAPAldose reductase1.1.1.210.443
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3q65NAPAldose reductase1.1.1.210.440
4xzmNAPAldo-keto reductase family 1 member B101.1.10.440