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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5av2KMPDeath-associated protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5av2KMPDeath-associated protein kinase 12.7.11.11.000
5av3KMPDeath-associated protein kinase 12.7.11.10.818
1jklANPDeath-associated protein kinase 12.7.11.10.628
3gu7ADPDeath-associated protein kinase 12.7.11.10.619
2yaaATPDeath-associated protein kinase 2/0.566
2w4jADPDeath-associated protein kinase 12.7.11.10.563
3bqr4RBDeath-associated protein kinase 3/0.560
1ig1ANPDeath-associated protein kinase 12.7.11.10.542
5aut2ANDeath-associated protein kinase 12.7.11.10.538
1jkkANPDeath-associated protein kinase 12.7.11.10.516
2ckeIQUDeath-associated protein kinase 2/0.515
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.514
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.512
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.508
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.502
4grb0XGCasein kinase II subunit alpha2.7.11.10.500
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.497
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.490
3gu83GUDeath-associated protein kinase 12.7.11.10.488
4ysjADPCalmodulin-like domain protein kinase/0.486
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.484
5cvfATPCasein kinase II subunit alpha2.7.11.10.481
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.480
4j99ACPFibroblast growth factor receptor 2/0.480
2vu3LZECyclin-dependent kinase 22.7.11.220.479
3lltANPProtein serine/threonine kinase-1/0.476
4qnyANPMitogen activated protein kinase, putative/0.473
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.472
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.472
4hvi19STyrosine-protein kinase JAK32.7.10.20.471
3lpbNVBTyrosine-protein kinase JAK2/0.469
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.469
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.468
4jia1K3Tyrosine-protein kinase JAK2/0.467
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.466
4bcmT7ZCyclin-dependent kinase 22.7.11.220.463
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.462
4hge15VTyrosine-protein kinase JAK2/0.462
2fvdLIACyclin-dependent kinase 22.7.11.220.461
3qxpX64Cyclin-dependent kinase 22.7.11.220.461
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.456
3juhANPCasein kinase II subunit alpha2.7.11.10.455
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.454
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
5auvAGIDeath-associated protein kinase 12.7.11.10.454
3my5RFZCyclin-dependent kinase 22.7.11.220.453
3q9xEMOCasein kinase II subunit alpha2.7.11.10.453
4l9i8PRRhodopsin kinase/0.453
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4bbfO19Tyrosine-protein kinase JAK2/0.452
4j95ACPFibroblast growth factor receptor 2/0.452
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.451
4jbpYPHAurora kinase A2.7.11.10.451
4e4n0NLTyrosine-protein kinase JAK1/0.450
4i5cC5ITyrosine-protein kinase JAK1/0.448
3at4CCKCasein kinase II subunit alpha2.7.11.10.447
4eooATPCyclin-dependent kinase 22.7.11.220.447
5dosATPAurora kinase A2.7.11.10.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.446
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3dfcANPDeath-associated protein kinase 12.7.11.10.445
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.445
2w05FRTCyclin-dependent kinase 22.7.11.220.443
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4c3pACPAurora kinase A2.7.11.10.443
4anmWULCasein kinase II subunit alpha2.7.11.10.441
3c4xATPRhodopsin kinase/0.440
4e6q0NVTyrosine-protein kinase JAK2/0.440