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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5aut2ANDeath-associated protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5aut2ANDeath-associated protein kinase 12.7.11.11.000
5av3KMPDeath-associated protein kinase 12.7.11.10.663
3gu7ADPDeath-associated protein kinase 12.7.11.10.658
5av2KMPDeath-associated protein kinase 12.7.11.10.644
1jklANPDeath-associated protein kinase 12.7.11.10.623
3bqr4RBDeath-associated protein kinase 3/0.550
2w4jADPDeath-associated protein kinase 12.7.11.10.541
2yaaATPDeath-associated protein kinase 2/0.533
1jkkANPDeath-associated protein kinase 12.7.11.10.526
1ig1ANPDeath-associated protein kinase 12.7.11.10.510
2ckeIQUDeath-associated protein kinase 2/0.509
4e4n0NLTyrosine-protein kinase JAK1/0.506
3gu83GUDeath-associated protein kinase 12.7.11.10.503
3juhANPCasein kinase II subunit alpha2.7.11.10.498
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.494
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.489
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.480
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.478
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.477
4eooATPCyclin-dependent kinase 22.7.11.220.474
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3nux3NVCyclin-dependent kinase 62.7.11.220.473
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.472
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4e6q0NVTyrosine-protein kinase JAK2/0.470
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.470
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.469
2uzbC75Cyclin-dependent kinase 22.7.11.220.468
3zxtACPDeath-associated protein kinase 12.7.11.10.465
4qnyANPMitogen activated protein kinase, putative/0.465
3lltANPProtein serine/threonine kinase-1/0.464
2f2uM77Rho-associated protein kinase 22.7.11.10.463
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.463
3qxpX64Cyclin-dependent kinase 22.7.11.220.463
3lpbNVBTyrosine-protein kinase JAK2/0.462
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.462
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.460
4bbfO19Tyrosine-protein kinase JAK2/0.460
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3my5RFZCyclin-dependent kinase 22.7.11.220.457
4hvi19STyrosine-protein kinase JAK32.7.10.20.457
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3mb714ICasein kinase II subunit alpha2.7.11.10.456
4l9i8PRRhodopsin kinase/0.456
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.455
2vu3LZECyclin-dependent kinase 22.7.11.220.455
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.455
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.455
4bcmT7ZCyclin-dependent kinase 22.7.11.220.455
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.455
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4ysjADPCalmodulin-like domain protein kinase/0.452
4otiMI1Serine/threonine-protein kinase N1/0.450
4crsAGSSerine/threonine-protein kinase N22.7.11.130.449
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.449
4hge15VTyrosine-protein kinase JAK2/0.449
4i5cC5ITyrosine-protein kinase JAK1/0.449
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.449
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
1m2pHNACasein kinase II subunit alpha2.7.11.10.446
2cjmATPCyclin-dependent kinase 22.7.11.220.446
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.446
3w2sW2REpidermal growth factor receptor2.7.10.10.446
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4grb0XGCasein kinase II subunit alpha2.7.11.10.445
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4jia1K3Tyrosine-protein kinase JAK2/0.444
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
5cvfATPCasein kinase II subunit alpha2.7.11.10.442
4fv9E71Mitogen-activated protein kinase 12.7.11.240.441
2j0lANPFocal adhesion kinase 12.7.10.20.440
2pvmP29Casein kinase II subunit alpha2.7.11.10.440
3js2VM1Fibroblast growth factor receptor 1/0.440
5dosATPAurora kinase A2.7.11.10.440