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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5aniES4Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5aniES4Cyclin-dependent kinase 22.7.11.221.000
3rahO1ZCyclin-dependent kinase 22.7.11.220.606
1e1xNW1Cyclin-dependent kinase 22.7.11.220.596
1w8cN69Cyclin-dependent kinase 22.7.11.220.591
1h0w207Cyclin-dependent kinase 22.7.11.220.584
3r71X86Cyclin-dependent kinase 22.7.11.220.577
3r1sX73Cyclin-dependent kinase 22.7.11.220.567
3rpo24ZCyclin-dependent kinase 22.7.11.220.566
3qwjX6ACyclin-dependent kinase 22.7.11.220.562
3qx2X63Cyclin-dependent kinase 22.7.11.220.560
4fklCK2Cyclin-dependent kinase 22.7.11.220.557
1gz8MBPCyclin-dependent kinase 22.7.11.220.555
1h0vUN4Cyclin-dependent kinase 22.7.11.220.554
2btrU73Cyclin-dependent kinase 22.7.11.220.550
3r7eX88Cyclin-dependent kinase 22.7.11.220.550
2exmZIPCyclin-dependent kinase 22.7.11.220.549
3ezrEZRCyclin-dependent kinase 22.7.11.220.547
3r73X87Cyclin-dependent kinase 22.7.11.220.544
3qqfX07Cyclin-dependent kinase 22.7.11.220.541
3iggEFQCyclin-dependent kinase 22.7.11.220.539
1b39ATPCyclin-dependent kinase 22.7.11.220.538
2a0cCK9Cyclin-dependent kinase 22.7.11.220.538
3r1yX76Cyclin-dependent kinase 22.7.11.220.537
3r7yZ04Cyclin-dependent kinase 22.7.11.220.537
2c69CT8Cyclin-dependent kinase 22.7.11.220.536
2a4lRRCCyclin-dependent kinase 22.7.11.220.535
3qqkX02Cyclin-dependent kinase 22.7.11.220.533
3qxoX65Cyclin-dependent kinase 22.7.11.220.533
3rk909ZCyclin-dependent kinase 22.7.11.220.531
4ek610KCyclin-dependent kinase 22.7.11.220.530
3rpr25ZCyclin-dependent kinase 22.7.11.220.524
3s00Z60Cyclin-dependent kinase 22.7.11.220.524
3s0o50ZCyclin-dependent kinase 22.7.11.220.522
3qzhX69Cyclin-dependent kinase 22.7.11.220.521
3r7uX96Cyclin-dependent kinase 22.7.11.220.520
1ckpPVBCyclin-dependent kinase 22.7.11.220.519
1ykr628Cyclin-dependent kinase 22.7.11.220.519
4ek816KCyclin-dependent kinase 22.7.11.220.519
4fkj11KCyclin-dependent kinase 22.7.11.220.518
2c68CT6Cyclin-dependent kinase 22.7.11.220.517
4fkpLS5Cyclin-dependent kinase 22.7.11.220.517
3r83Z14Cyclin-dependent kinase 22.7.11.220.516
3rpv26ZCyclin-dependent kinase 22.7.11.220.516
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.514
3qqhX0ACyclin-dependent kinase 22.7.11.220.514
3rni21ZCyclin-dependent kinase 22.7.11.220.514
4fki09KCyclin-dependent kinase 22.7.11.220.513
3raiX85Cyclin-dependent kinase 22.7.11.220.512
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.511
1b38ATPCyclin-dependent kinase 22.7.11.220.510
3rm618ZCyclin-dependent kinase 22.7.11.220.510
1vyw292Cyclin-dependent kinase 22.7.11.220.509
3r9nZ68Cyclin-dependent kinase 22.7.11.220.509
3lfsA07Cyclin-dependent kinase 22.7.11.220.508
1h1r6CPCyclin-dependent kinase 22.7.11.220.507
3lfnA27Cyclin-dependent kinase 22.7.11.220.507
3r6xX84Cyclin-dependent kinase 22.7.11.220.507
1vyzN5BCyclin-dependent kinase 22.7.11.220.506
2r3gSC9Cyclin-dependent kinase 22.7.11.220.506
1e1vCMGCyclin-dependent kinase 22.7.11.220.505
2r3iSCFCyclin-dependent kinase 22.7.11.220.505
3qruX19Cyclin-dependent kinase 22.7.11.220.503
2r3fSC8Cyclin-dependent kinase 22.7.11.220.502
3rm719ZCyclin-dependent kinase 22.7.11.220.502
3qzgX67Cyclin-dependent kinase 22.7.11.220.501
3sqq99ZCyclin-dependent kinase 22.7.11.220.501
3r28XA0Cyclin-dependent kinase 22.7.11.220.500
1h1q2A6Cyclin-dependent kinase 22.7.11.220.499
2c6mDT5Cyclin-dependent kinase 22.7.11.220.497
2c6o4SPCyclin-dependent kinase 22.7.11.220.496
3roy22ZCyclin-dependent kinase 22.7.11.220.496
3qqlX03Cyclin-dependent kinase 22.7.11.220.495
3r8uZ31Cyclin-dependent kinase 22.7.11.220.495
3r9hZ67Cyclin-dependent kinase 22.7.11.220.494
3s2pPMUCyclin-dependent kinase 22.7.11.220.494
2r3o2SCCyclin-dependent kinase 22.7.11.220.493
2r64740Cyclin-dependent kinase 22.7.11.220.493
2uzoC62Cyclin-dependent kinase 22.7.11.220.493
4ez30S0Cyclin-dependent kinase 22.7.11.220.493
4fkg4CKCyclin-dependent kinase 22.7.11.220.493
2vtsLZCCyclin-dependent kinase 22.7.11.220.491
2w05FRTCyclin-dependent kinase 22.7.11.220.491
3ddqRRCCyclin-dependent kinase 22.7.11.220.491
1h1pCMGCyclin-dependent kinase 22.7.11.220.490
3qtuX44Cyclin-dependent kinase 22.7.11.220.490
1v1k3FPCyclin-dependent kinase 22.7.11.220.489
2btsU32Cyclin-dependent kinase 22.7.11.220.488
4nj32KDCyclin-dependent kinase 22.7.11.220.488
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.487
3qtzX42Cyclin-dependent kinase 22.7.11.220.486
3r7iX9ICyclin-dependent kinase 22.7.11.220.486
3lfqA28Cyclin-dependent kinase 22.7.11.220.485
3qwkX62Cyclin-dependent kinase 22.7.11.220.485
4bcpT3CCyclin-dependent kinase 22.7.11.220.485
4eor4SPCyclin-dependent kinase 22.7.11.220.485
4lyn1YGCyclin-dependent kinase 22.7.11.220.485
2r3mSCXCyclin-dependent kinase 22.7.11.220.484
4fkq42KCyclin-dependent kinase 22.7.11.220.484
1y91CT9Cyclin-dependent kinase 22.7.11.220.483
2wotZZGTGF-beta receptor type-12.7.11.300.483
3r8lZ30Cyclin-dependent kinase 22.7.11.220.483
2b55D31Cyclin-dependent kinase 22.7.11.220.482
3ig7EFPCyclin-dependent kinase 22.7.11.220.482
3r7vZ02Cyclin-dependent kinase 22.7.11.220.481
2b52D42Cyclin-dependent kinase 22.7.11.220.479
2c6iDT1Cyclin-dependent kinase 22.7.11.220.479
1oiuN76Cyclin-dependent kinase 22.7.11.220.478
2c4g514Cyclin-dependent kinase 22.7.11.220.478
3qziX72Cyclin-dependent kinase 22.7.11.220.478
4kd11QKCyclin-dependent kinase 22.7.11.220.477
1ke7LS3Cyclin-dependent kinase 22.7.11.220.476
3fz1B98Cyclin-dependent kinase 22.7.11.220.476
1oi9N20Cyclin-dependent kinase 22.7.11.220.475
1p2a5BNCyclin-dependent kinase 22.7.11.220.475
3rk708ZCyclin-dependent kinase 22.7.11.220.475
1oitHDTCyclin-dependent kinase 22.7.11.220.474
3r1qX75Cyclin-dependent kinase 22.7.11.220.474
4eon1ROCyclin-dependent kinase 22.7.11.220.474
1gih1PUCyclin-dependent kinase 22.7.11.220.473
2r3lSCWCyclin-dependent kinase 22.7.11.220.473
3qrtX14Cyclin-dependent kinase 22.7.11.220.473
3r8pZ46Cyclin-dependent kinase 22.7.11.220.473
4eos1ROCyclin-dependent kinase 22.7.11.220.473
2c6kDT2Cyclin-dependent kinase 22.7.11.220.472
3ql8X01Cyclin-dependent kinase 22.7.11.220.471
1pxjCK2Cyclin-dependent kinase 22.7.11.220.470
1unlRRCCyclin-dependent-like kinase 52.7.11.10.470
2r3r6SCCyclin-dependent kinase 22.7.11.220.470
4acm7YGCyclin-dependent kinase 22.7.11.220.470
4fkt48KCyclin-dependent kinase 22.7.11.220.470
1ke5LS1Cyclin-dependent kinase 22.7.11.220.469
1ke6LS2Cyclin-dependent kinase 22.7.11.220.469
2uznC96Cyclin-dependent kinase 22.7.11.220.468
3py0SU9Cyclin-dependent kinase 22.7.11.220.468
2r3p3SCCyclin-dependent kinase 22.7.11.220.467
3pj8404Cyclin-dependent kinase 22.7.11.220.467
1pxmCK5Cyclin-dependent kinase 22.7.11.220.465
1pxoCK7Cyclin-dependent kinase 22.7.11.220.465
2w06FRVCyclin-dependent kinase 22.7.11.220.465
2wpa889Cyclin-dependent kinase 22.7.11.220.465
3ddpRC8Cyclin-dependent kinase 22.7.11.220.465
3qu0X40Cyclin-dependent kinase 22.7.11.220.465
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.465
3qtrX36Cyclin-dependent kinase 22.7.11.220.464
4fkr45KCyclin-dependent kinase 22.7.11.220.464
3qx4X4BCyclin-dependent kinase 22.7.11.220.463
3unk0BYCyclin-dependent kinase 22.7.11.220.463
1pxkCK3Cyclin-dependent kinase 22.7.11.220.462
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.461
1di8DTQCyclin-dependent kinase 22.7.11.220.460
1h1s4SPCyclin-dependent kinase 22.7.11.220.459
1oguST8Cyclin-dependent kinase 22.7.11.220.459
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.459
3pxyJWSCyclin-dependent kinase 22.7.11.220.459
1w0xOLOCyclin-dependent kinase 22.7.11.220.458
2xmyCDKCyclin-dependent kinase 22.7.11.220.458
3ti1B49Cyclin-dependent kinase 22.7.11.220.457
1g5sI17Cyclin-dependent kinase 22.7.11.220.455
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.455
4bgh3I6Cyclin-dependent kinase 22.7.11.220.455
2vthLZ2Cyclin-dependent kinase 22.7.11.220.454
3rk507ZCyclin-dependent kinase 22.7.11.220.454
1oirHDYCyclin-dependent kinase 22.7.11.220.452
2b54D05Cyclin-dependent kinase 22.7.11.220.452
3s1h56ZCyclin-dependent kinase 22.7.11.220.452
1ke9LS5Cyclin-dependent kinase 22.7.11.220.451
1oiqHDUCyclin-dependent kinase 22.7.11.220.451
4bcoT6QCyclin-dependent kinase 22.7.11.220.451
3qtxX43Cyclin-dependent kinase 22.7.11.220.450
1y8yCT7Cyclin-dependent kinase 22.7.11.220.449
2iw94SPCyclin-dependent kinase 22.7.11.220.449
3rmf20ZCyclin-dependent kinase 22.7.11.220.449
2c5yMTWCyclin-dependent kinase 22.7.11.220.448
3bhtMFRCyclin-dependent kinase 22.7.11.220.448
3rak03ZCyclin-dependent kinase 22.7.11.220.448
1hckATPCyclin-dependent kinase 22.7.11.220.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
3qtsX46Cyclin-dependent kinase 22.7.11.220.447
3unj0BXCyclin-dependent kinase 22.7.11.220.447
2c6lDT4Cyclin-dependent kinase 22.7.11.220.446
2vttLZDCyclin-dependent kinase 22.7.11.220.446
2iw84SPCyclin-dependent kinase 22.7.11.220.444
2w1hL0FCyclin-dependent kinase 22.7.11.220.444
3dogNNNCyclin-dependent kinase 22.7.11.220.442
4fko20KCyclin-dependent kinase 22.7.11.220.442
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4bcmT7ZCyclin-dependent kinase 22.7.11.220.441
4bcnT9NCyclin-dependent kinase 22.7.11.220.441
1oiyN41Cyclin-dependent kinase 22.7.11.220.440
4fkw62KCyclin-dependent kinase 22.7.11.220.440