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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5aku29FTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5aku29FTankyrase-22.4.2.301.000
4buiW2ETankyrase-22.4.2.300.819
4but31FTankyrase-22.4.2.300.774
4bufF36Tankyrase-22.4.2.300.766
4l0s1UZTankyrase-22.4.2.300.755
4bu908CTankyrase-22.4.2.300.723
4l0v1V1Tankyrase-22.4.2.300.681
4l2f1V3Tankyrase-22.4.2.300.674
4kzl20DTankyrase-22.4.2.300.668
4avwG18Tankyrase-22.4.2.300.663
4bueJQFTankyrase-22.4.2.300.656
4l0i1UWTankyrase-22.4.2.300.647
4l33F70Tankyrase-22.4.2.300.646
4hkiFLNTankyrase-22.4.2.300.644
4l2k1V8Tankyrase-22.4.2.300.640
4l31F08Tankyrase-22.4.2.300.639
4l321VFTankyrase-22.4.2.300.638
4l341VGTankyrase-22.4.2.300.637
4hkkAGITankyrase-22.4.2.300.634
4hlh20DTankyrase-22.4.2.300.627
4l2g1V4Tankyrase-22.4.2.300.627
4l0t1V0Tankyrase-22.4.2.300.624
4kzuA73Tankyrase-22.4.2.300.621
4iueAJ4Tankyrase-22.4.2.300.620
4bud29FTankyrase-22.4.2.300.618
4buxF35Tankyrase-22.4.2.300.617
4hknLU2Tankyrase-22.4.2.300.617
4j22AJ7Tankyrase-22.4.2.300.604
4bus32FTankyrase-22.4.2.300.600
4hlf15ZTankyrase-22.4.2.300.597
4hl515WTankyrase-22.4.2.300.593
4hlm16STankyrase-22.4.2.300.589
4j21AJ6Tankyrase-22.4.2.300.577
3p0pNNFTankyrase-22.4.2.300.574
4hmhF94Tankyrase-22.4.2.300.554
3u9y09LTankyrase-22.4.2.300.547
4buv16ITankyrase-22.4.2.300.526
4tkg09LTankyrase-22.4.2.300.520
4pnrG18Tankyrase-22.4.2.300.518
4buwF33Tankyrase-22.4.2.300.516
4bj9UHBTankyrase-22.4.2.300.505
4bs4A64Tankyrase-22.4.2.300.504
4bjbP34Tankyrase-22.4.2.300.496
4msk2C8Tankyrase-12.4.2.300.492
4pnmNU1Tankyrase-22.4.2.300.492
4buuF38Tankyrase-22.4.2.300.491
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.483
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.462
4hyf1AKTankyrase-22.4.2.300.457
4l091URTankyrase-22.4.2.300.454
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.445
4tjy3GNTankyrase-22.4.2.300.443