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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.626
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.608
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.595
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.589
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.583
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.582
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.573
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.571
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.569
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.563
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.556
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.554
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.547
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.540
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.540
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.535
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.528
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.528
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.526
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.517
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.502
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2yaaATPDeath-associated protein kinase 2/0.455
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3lltANPProtein serine/threonine kinase-1/0.449
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.150.443
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.442
4qnyANPMitogen activated protein kinase, putative/0.442
2f2uM77Rho-associated protein kinase 22.7.11.10.441
3ncz3NCRho-associated protein kinase 12.7.11.10.440