Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4yvj | SFG | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4yvj | SFG | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 1.000 | |
| 4mcd | 22L | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.568 | |
| 1uam | SAH | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.561 | |
| 1ual | SAH | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.535 | |
| 4ig6 | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.506 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.496 | |
| 4yvh | SFG | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.494 | |
| 1p9p | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.492 | |
| 1uak | SAM | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.488 | |
| 1tww | HH2 | Dihydropteroate synthase | / | 0.486 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.486 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.483 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.476 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.476 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.474 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.474 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.474 | |
| 3etg | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.474 | |
| 4yvg | SAM | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.474 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.473 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.473 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.472 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.471 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.471 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.471 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.469 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.469 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.468 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.468 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.467 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.467 | |
| 3au8 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.467 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.467 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.466 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.466 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.466 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.466 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.466 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.466 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.466 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.466 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.465 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.465 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.465 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 1ork | ATC | Tetracycline repressor protein class D | / | 0.464 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.464 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.464 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.464 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.463 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.463 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.463 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.463 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.462 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.462 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.462 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.462 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.462 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.462 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.461 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 1w7i | ADP | Unconventional myosin-Va | / | 0.461 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.461 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.460 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.460 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.460 | |
| 3zuy | TCH | Transporter | / | 0.460 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.459 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.459 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.459 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.459 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.459 | |
| 4phl | PIL | Phosphodiesterase | / | 0.459 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.458 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4biw | ANP | Sensor histidine kinase CpxA | / | 0.458 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.458 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.458 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.458 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.457 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.457 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.457 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.457 | |
| 4ceq | QCH | Integrase | / | 0.457 | |
| 4j49 | 1J1 | Uncharacterized protein | / | 0.457 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.456 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.456 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.456 | |
| 1gqt | ACP | Ribokinase | / | 0.455 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.455 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.455 | |
| 3nzp | PLP | Arginine decarboxylase | / | 0.455 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.455 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.455 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.455 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.455 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 2ejz | SAH | Diphthine synthase | / | 0.454 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.454 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.454 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.453 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.453 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.453 | |
| 1rbz | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.453 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.453 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.453 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.453 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.453 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.452 | |
| 1hwz | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.452 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.452 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.452 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.452 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.452 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.452 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.452 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.452 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.452 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.452 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.452 | |
| 4jic | FMN | GTN Reductase | / | 0.452 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.452 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.452 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.452 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.451 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.451 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.451 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.451 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.451 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.451 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.451 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.451 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 4x3m | ADN | RNA 2'-O ribose methyltransferase | / | 0.451 | |
| 1h72 | ANP | Homoserine kinase | 2.7.1.39 | 0.450 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.450 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.450 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.450 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 3g2h | KOT | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.450 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.450 | |
| 3r3c | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.450 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.450 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.450 | |
| 4uoc | NCN | CinA-like protein | / | 0.450 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.450 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.449 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.449 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.449 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.449 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.449 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.449 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.449 | |
| 2ii5 | CO6 | Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial | 2.3.1.168 | 0.449 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.449 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.449 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.449 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.448 | |
| 2dsh | SAH | Diphthine synthase | / | 0.448 | |
| 3i0a | DBH | Neutrophil gelatinase-associated lipocalin | / | 0.448 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.448 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.448 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.448 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.448 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.448 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.448 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.448 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.447 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.447 | |
| 2nv4 | SAM | S-adenosyl-L-methionine-binding protein AF_0241 | / | 0.447 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.447 | |
| 3w2m | ZRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.447 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.447 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.446 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.446 | |
| 1szj | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.446 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.446 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.446 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.446 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.446 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.446 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.446 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.446 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.446 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.446 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.446 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.445 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.445 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.445 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.445 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.445 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.445 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.445 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.445 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.445 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.445 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4eub | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.445 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.445 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.444 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.444 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.444 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.444 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.444 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.444 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3a3b | RBF | Lumazine protein | / | 0.444 | |
| 3ilt | TRU | Glutamate receptor 2 | / | 0.444 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.444 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.444 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.443 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.443 | |
| 1l4k | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.443 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.443 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2cx8 | SAH | Ribosomal RNA small subunit methyltransferase E | / | 0.443 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 2nad | NAD | Formate dehydrogenase | / | 0.443 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.443 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.443 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.443 | |
| 3iaa | TYD | CalG2 | / | 0.443 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.443 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3v49 | PK0 | Androgen receptor | / | 0.443 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.443 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.443 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.443 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.443 | |
| 5aga | ANP | DNA polymerase theta | / | 0.443 | |
| 5kl9 | COA | Acyl-CoA thioester hydrolase YbgC | 3.1.2 | 0.443 | |
| 1g9b | BAB | Botulinum neurotoxin type B | 3.4.24.69 | 0.442 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1orh | SAH | Protein arginine N-methyltransferase 1 | / | 0.442 | |
| 1rct | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.442 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.442 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.442 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.442 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.442 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 4blr | UTP | NTPase P4 | / | 0.442 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.442 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.442 | |
| 4jal | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.442 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.442 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 4p8r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.441 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1iy8 | NAD | Levodione reductase | / | 0.441 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.441 | |
| 1zpt | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.441 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.441 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.441 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.441 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.441 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.441 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.441 | |
| 3nwz | COA | BH2602 protein | / | 0.441 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3r32 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.441 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.441 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.441 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.441 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.441 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.440 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.440 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.440 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.440 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.440 | |
| 2q3k | MUW | Gag-Pol polyprotein | / | 0.440 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.440 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.440 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.440 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.440 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4g3p | UD1 | Bifunctional protein GlmU | / | 0.440 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.440 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.440 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.440 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.440 |