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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xsdUMPThymidylate synthase2.1.1.45

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4xsdUMPThymidylate synthase2.1.1.451.000
4irrUMPThymidylate synthase/0.512
4dq1UMPThymidylate synthase/0.490
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.481
4eb4UMPThymidylate synthase2.1.1.450.481
4einNOHThymidylate synthase2.1.1.450.480
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.474
3hb8UMPThymidylate synthase2.1.1.450.469
1an5CB3Thymidylate synthase/0.456
3qj7UMPThymidylate synthase ThyA/0.452
5by6UMPThymidylate synthase/0.451
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
4iskUMPThymidylate synthase/0.447
1ci7UMPThymidylate synthase2.1.1.450.444
4e5oUMPThymidylate synthase2.1.1.450.442
4psgNOHThymidylate synthase/0.441