scPDB - Distribution of Cavity Similarity values of 4xe6 entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4xe6	06U	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4xe6	06U	Dihydrofolate reductase	1.5.1.3	1.000
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.539
3qlz	QLZ	Uncharacterized protein	/	0.533
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.525
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.524
3sa1	6DR	Dihydrofolate reductase	/	0.516
3cse	N22	Uncharacterized protein	/	0.514
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.511
4ele	31I	Dihydrofolate reductase	/	0.511
3fl8	RAR	Dihydrofolate reductase	/	0.510
3jwc	EKB	Dihydrofolate reductase	/	0.509
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.506
3eek	53S	Uncharacterized protein	/	0.506
4h98	14Q	Uncharacterized protein	/	0.504
2w9g	TOP	Dihydrofolate reductase	1.5.1.3	0.501
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.501
3jw5	TOP	Dihydrofolate reductase	/	0.501
4elg	52J	Dihydrofolate reductase	/	0.501
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.500
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.497
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.496
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.495
4elb	34S	Dihydrofolate reductase	/	0.494
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.493
3jwm	5WB	Dihydrofolate reductase	/	0.493
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.492
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.491
4elb	34R	Dihydrofolate reductase	/	0.491
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.488
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.488
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.486
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.486
2w3v	TOP	Dihydrofolate reductase	/	0.484
3m08	RAR	Dihydrofolate reductase	1.5.1.3	0.484
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.484
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.483
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.483
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.483
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.482
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.481
3qlr	NDP	Dihydrofolate reductase	1.5.1.3	0.480
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.480
3fy9	XCF	Dihydrofolate reductase	1.5.1.3	0.476
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.476
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.475
3eej	53R	Uncharacterized protein	/	0.475
3eem	53V	Uncharacterized protein	/	0.475
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.474
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.473
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.472
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.471
2qk8	MTX	Dihydrofolate reductase	/	0.471
3eel	53T	Uncharacterized protein	/	0.471
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.471
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.470
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.469
5hi6	MTX	Dihydrofolate reductase	/	0.469
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.468
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.468
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.468
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.467
3ia4	MTX	Dihydrofolate reductase	/	0.467
3sa2	7DR	Dihydrofolate reductase	/	0.467
3srw	Q27	Dihydrofolate reductase	1.5.1.3	0.467
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.466
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.466
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.464
3inv	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.464
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.464
3sai	9DR	Dihydrofolate reductase	/	0.463
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.463
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.462
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.461
2h2q	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.461
3qls	NDP	Dihydrofolate reductase	1.5.1.3	0.460
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.459
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.458
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.458
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.457
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.457
2zza	FOL	Dihydrofolate reductase	/	0.456
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.455
4p66	MTX	Dihydrofolate reductase	/	0.455
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.454
3qlx	QLR	Uncharacterized protein	/	0.454
4elh	53I	Dihydrofolate reductase	/	0.453
3tqb	FOL	Dihydrofolate reductase	/	0.452
1dis	BDM	Dihydrofolate reductase	1.5.1.3	0.450
3i8a	N22	Dihydrofolate reductase	1.5.1.3	0.450
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.449
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.449
3qly	55V	Uncharacterized protein	/	0.449
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.448
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.448
3clb	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.448
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.448
3sru	Q26	Dihydrofolate reductase	1.5.1.3	0.448
4elf	35I	Dihydrofolate reductase	/	0.448
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.447
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.447
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.447
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.446
1ai9	NDP	Dihydrofolate reductase	1.5.1.3	0.445
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.445
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.444
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.444
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.443
1rj6	AZM	Carbonic anhydrase 14	4.2.1.1	0.443
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.443
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3fyv	XCF	Dihydrofolate reductase	1.5.1.3	0.442
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.442
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.441
3srr	Q20	Dihydrofolate reductase	1.5.1.3	0.441
1m79	MQ1	Dihydrofolate reductase	1.5.1.3	0.440
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440
3jw3	TOP	Dihydrofolate reductase	/	0.440
4j6d	TES	Cytochrome P450 monooxygenase	/	0.440