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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xdmGDMHeat shock cognate 90 kDa protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4xdmGDMHeat shock cognate 90 kDa protein/1.000
1osfKOSHeat shock protein HSP 90-alpha/0.652
4asf62UATP-dependent molecular chaperone HSP82/0.621
1yetGDMHeat shock protein HSP 90-alpha/0.619
4xclAGSHeat shock cognate 90 kDa protein/0.605
2vw5BC6ATP-dependent molecular chaperone HSP82/0.593
4xcjADPHeat shock cognate 90 kDa protein/0.580
2byh2D7Heat shock protein HSP 90-alpha/0.578
4jqlVJ6Heat shock protein HSP 90-alpha/0.577
2exlGDMEndoplasmin/0.571
2byi2DDHeat shock protein HSP 90-alpha/0.568
2esaGDMEndoplasmin/0.567
4b7p9UNHeat shock protein HSP 90-alpha/0.563
2yegXQGHeat shock protein HSP 90-alpha/0.559
4asg814ATP-dependent molecular chaperone HSP82/0.559
4egiB2JHeat shock protein HSP 90-alpha/0.554
4bqjXKLHeat shock protein HSP 90-alpha/0.549
3t10ACPHeat shock protein HSP 90-alpha/0.547
1yc34BCHeat shock protein HSP 90-alpha/0.546
3c11GDMATP-dependent molecular chaperone HSP82/0.545
2xx213CATP-dependent molecular chaperone HSP82/0.541
3hz142CHeat shock protein HSP 90-alpha/0.539
2xk2ADPHeat shock protein HSP 90-alpha/0.537
3vhaVHAHeat shock protein HSP 90-alpha/0.535
3pejBC2Endoplasmin homolog, putative/0.533
2yefANPHeat shock protein HSP 90-alpha/0.531
4ipeANPTNF receptor-associated protein 1/0.530
3k974CDHeat shock protein HSP 90-alpha/0.525
2qg0A94Heat shock protein HSP 90-alpha/0.523
4as94QSATP-dependent molecular chaperone HSP82/0.522
4ce17FKATP-dependent molecular chaperone HSP82/0.522
1byqADPHeat shock protein HSP 90-alpha/0.521
2xabVHDHeat shock protein HSP 90-alpha/0.518
3hyz42CHeat shock protein HSP 90-alpha/0.518
1u0zRDCEndoplasmin/0.517
3hhu819Heat shock protein HSP 90-alpha/0.516
3t0zATPHeat shock protein HSP 90-alpha/0.516
2xjxXJXHeat shock protein HSP 90-alpha/0.514
4eftEFTHeat shock protein HSP 90-alpha/0.514
3d0bSNXHeat shock protein HSP 90-alpha/0.512
3r4oFU3Heat shock protein HSP 90-alpha/0.512
2xcmADPCytosolic heat shock protein 90/0.511
2wi5ZZ5Heat shock protein HSP 90-alpha/0.509
2fypRDEEndoplasmin/0.507
4egkRDCHeat shock protein HSP 90-alpha/0.507
2xjjL81Heat shock protein HSP 90-alpha/0.504
1i58ADPChemotaxis protein CheA2.7.13.30.503
2iorADPChaperone protein HtpG/0.503
4ivgANPTNF receptor-associated protein 1/0.501
3pehIBDEndoplasmin homolog, putative/0.498
2wi6ZZ6Heat shock protein HSP 90-alpha/0.497
2vcj2EQHeat shock protein HSP 90-alpha/0.496
4xc0ACPHeat shock cognate 90 kDa protein/0.493
2xd6XD6ATP-dependent molecular chaperone HSP82/0.489
2breKJ2ATP-dependent molecular chaperone HSP82/0.487
2gfdRDAEndoplasmin/0.487
5f5rANPHeat shock protein 75 kDa, mitochondrial/0.487
2iwsNP4ATP-dependent molecular chaperone HSP82/0.486
1yc14BCHeat shock protein HSP 90-alpha/0.485
2xhrC0PHeat shock protein HSP 90-alpha/0.484
2o1vADPEndoplasmin/0.481
1bgqRDCATP-dependent molecular chaperone HSP82/0.478
1i59ANPChemotaxis protein CheA2.7.13.30.478
2bz5AB4Heat shock protein HSP 90-alpha/0.478
3whaWHAHeat shock protein HSP 90-alpha/0.478
1yc443PHeat shock protein HSP 90-alpha/0.477
2yeiXQIHeat shock protein HSP 90-alpha/0.477
2yejZZ3Heat shock protein HSP 90-alpha/0.476
2yejXQKHeat shock protein HSP 90-alpha/0.475
2ykiYKIHeat shock protein HSP 90-alpha/0.475
3hz5Z64Heat shock protein HSP 90-alpha/0.472
4fcr0TMHeat shock protein HSP 90-alpha/0.472
2bt0CT5Heat shock protein HSP 90-alpha/0.471
2o1uANPEndoplasmin/0.471
2wi1ZZ2Heat shock protein HSP 90-alpha/0.470
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.468
1y4sADPChaperone protein HtpG/0.466
2ye42FYHeat shock protein HSP 90-alpha/0.465
2hchN5AEndoplasmin/0.463
4bcnT9NCyclin-dependent kinase 22.7.11.220.463
4hy6FJ1Heat shock protein HSP 90-alpha/0.458
2uwd2GGHeat shock protein HSP 90-alpha/0.457
2zdxP4A[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.457
2yi66QMHeat shock protein HSP 90-alpha/0.456
1i5cADPChemotaxis protein CheA2.7.13.30.455
1kvtUPGUDP-glucose 4-epimerase5.1.3.20.455
4egh0OYHeat shock protein HSP 90-alpha/0.455
1jm6ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.454
2bsmBSMHeat shock protein HSP 90-alpha/0.454
2vci2GJHeat shock protein HSP 90-alpha/0.453
2zbaZBATrichothecene 3-O-acetyltransferase/0.453
1i58ACPChemotaxis protein CheA2.7.13.30.451
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.451
1k6pXN3Gag-Pol polyprotein3.4.23.160.449
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.449
4xivADPChemotaxis protein CheA2.7.13.30.449
2hg1N5OEndoplasmin/0.448
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.447
4bcqTJFCyclin-dependent kinase 22.7.11.220.446
2yecXQ0Heat shock protein HSP 90-alpha/0.445
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.444
2cgfP2NATP-dependent molecular chaperone HSP82/0.443
2i40BLZCyclin-dependent kinase 22.7.11.220.443
2yjwYJWHeat shock protein HSP 90-alpha/0.443
4awq592Heat shock protein HSP 90-alpha/0.443
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.443
2yk2YJWHeat shock protein HSP 90-alpha/0.441
3rlp3RPHeat shock protein HSP 90-alpha/0.441
2pmdGNPTranslation initiation factor 2 subunit gamma/0.440
3g5hYTTMycocyclosin synthase1.14.21.90.440