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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4x5hFOLDihydrofolate reductase1.5.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4x5hFOLDihydrofolate reductase1.5.1.31.000
4x5jFOLDihydrofolate reductase1.5.1.30.739
4x5iFOLDihydrofolate reductase1.5.1.30.713
1ra3MTXDihydrofolate reductase1.5.1.30.669
1ra8FOLDihydrofolate reductase1.5.1.30.667
1dyiFOLDihydrofolate reductase1.5.1.30.646
4dfrMTXDihydrofolate reductase1.5.1.30.629
1dyhDZFDihydrofolate reductase1.5.1.30.623
1jolFFODihydrofolate reductase1.5.1.30.617
1ddrMTXDihydrofolate reductase1.5.1.30.611
1draMTXDihydrofolate reductase1.5.1.30.609
1rb2FOLDihydrofolate reductase1.5.1.30.607
1re7FOLDihydrofolate reductase1.5.1.30.606
2drcMTXDihydrofolate reductase1.5.1.30.600
1dhjMTXDihydrofolate reductase1.5.1.30.598
1dyjDDFDihydrofolate reductase1.5.1.30.586
1ra3NAPDihydrofolate reductase1.5.1.30.585
1rb3MTXDihydrofolate reductase1.5.1.30.579
1ddsMTXDihydrofolate reductase1.5.1.30.575
5hi6MTXDihydrofolate reductase/0.560
1rd7FOLDihydrofolate reductase1.5.1.30.551
3och2MXDihydrofolate reductase1.5.1.30.535
1s3vTQDDihydrofolate reductase1.5.1.30.534
3nxxNDPDihydrofolate reductase1.5.1.30.526
4dbzNDPPutative ketoacyl reductase1.3.10.504
2w3bNDPDihydrofolate reductase1.5.1.30.498
1tdrMTXDihydrofolate reductase1.5.1.30.495
1ia1NDPDihydrofolate reductase1.5.1.30.493
3drcMTXDihydrofolate reductase1.5.1.30.488
3qlsNDPDihydrofolate reductase1.5.1.30.487
3tqaNDPDihydrofolate reductase/0.486
4g95OAGDihydrofolate reductase1.5.1.30.486
5eccNAPDehydrofolate reductase type I/0.484
1drbMTXDihydrofolate reductase1.5.1.30.483
1dr3HBIDihydrofolate reductase1.5.1.30.482
1drfFOLDihydrofolate reductase1.5.1.30.482
1dhiMTXDihydrofolate reductase1.5.1.30.478
2d0kFOLDihydrofolate reductase1.5.1.30.478
1rx4DDFDihydrofolate reductase1.5.1.30.476
3n0hTOPDihydrofolate reductase1.5.1.30.476
1rx5DDFDihydrofolate reductase1.5.1.30.475
3lqfNADGalactitol dehydrogenase/0.475
2cig1DGDihydrofolate reductase1.5.1.30.474
3qlrNDPDihydrofolate reductase1.5.1.30.474
1dr2TAPDihydrofolate reductase1.5.1.30.473
1diuBDMDihydrofolate reductase1.5.1.30.472
1rx1NAPDihydrofolate reductase1.5.1.30.472
1rx7FOLDihydrofolate reductase1.5.1.30.472
2dhfDZFDihydrofolate reductase1.5.1.30.470
8dfrNDPDihydrofolate reductase1.5.1.30.470
3ai3NDPNADPH-sorbose reductase/0.468
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.468
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.468
1dg8NDPDihydrofolate reductase1.5.1.30.467
3s7a684Dihydrofolate reductase1.5.1.30.467
4dc0NDPPutative ketoacyl reductase1.3.10.467
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.467
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.467
1dr3TAPDihydrofolate reductase1.5.1.30.465
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.465
3oafOAGDihydrofolate reductase1.5.1.30.465
3s3vTOPDihydrofolate reductase1.5.1.30.465
1dhfFOLDihydrofolate reductase1.5.1.30.463
1m78NDPDihydrofolate reductase1.5.1.30.463
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.463
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.463
3zhbNAPPutative dehydrogenase/0.463
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.462
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.462
4kne1CYDihydrofolate reductase1.5.1.30.462
1ia3TQ5Dihydrofolate reductase1.5.1.30.460
4m6jNDPDihydrofolate reductase1.5.1.30.460
1rx8NAPDihydrofolate reductase1.5.1.30.459
1dr5NAPDihydrofolate reductase1.5.1.30.458
3d84NDPDihydrofolate reductase1.5.1.30.458
2xw7NDPDihydrofolate reductase/0.457
4ips1G4Mycocyclosin synthase1.14.21.90.455
1u71MXADihydrofolate reductase1.5.1.30.454
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1f8fNADBenzyl alcohol dehydrogenase/0.452
1pd9CO4Dihydrofolate reductase1.5.1.30.452
1tehNADAlcohol dehydrogenase class-31.1.1.10.452
3vyeVYERenin3.4.23.150.452
1tsxUMPThymidylate synthase/0.451
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.451
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.451
4q71FADBifunctional protein PutA/0.450
1xddAAYIntegrin alpha-L/0.449
4ktkKTKCytochrome P450/0.449
1rneC60Renin3.4.23.150.448
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.448
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1ai9NDPDihydrofolate reductase1.5.1.30.447
1bpjUMPThymidylate synthase/0.447
1drhNAPDihydrofolate reductase1.5.1.30.447
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.447
2hfuMEVMevalonate kinase/0.446
3s1dZIRCytokinin dehydrogenase 11.5.99.120.446
1jmhUMPThymidylate synthase/0.445
1mokFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.445
2fzwNADAlcohol dehydrogenase class-31.1.1.10.445
1rx8FOLDihydrofolate reductase1.5.1.30.444
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2rlcCHDCholoylglycine hydrolase3.5.1.240.444
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.444
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.443
4kl9NDPDihydrofolate reductase1.5.1.30.443
2ahrNAPPyrroline-5-carboxylate reductase/0.442
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.442
4nmdFDABifunctional protein PutA/0.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.441
3otwCOAPhosphopantetheine adenylyltransferase/0.440
4ej1FOLDihydrofolate reductase1.5.1.30.440