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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wx2F6FTryptophan synthase alpha chain

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4wx2F6FTryptophan synthase alpha chain/1.000
4wx2F6FTryptophan synthase beta chain4.2.1.201.000
4zqcF6FTryptophan synthase alpha chain/0.678
2cleF6FTryptophan synthase alpha chain/0.598
4y6gF6FTryptophan synthase alpha chain/0.567
1k7fIAVTryptophan synthase alpha chain/0.548
2clfF6FTryptophan synthase alpha chain/0.548
1qoqIGPTryptophan synthase alpha chain/0.546
1k8zIAGTryptophan synthase alpha chain/0.544
1kfbIGPTryptophan synthase alpha chain/0.503
1kfcIPLTryptophan synthase alpha chain/0.481
5dp2NAPCurF/0.468
3rtnRTNBeta-secretase 13.4.23.460.465
1k8y13PTryptophan synthase alpha chain/0.464
3h3r14HCollagen type IV alpha-3-binding protein/0.462
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.459
2rhgIGPTryptophan synthase alpha chain/0.455
1s7gNADNAD-dependent protein deacylase 2/0.454
2rh9IGPTryptophan synthase alpha chain/0.451
2x7hPFNProstaglandin reductase 310.450
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.446
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.446
3rsv3RSBeta-secretase 13.4.23.460.445
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442