sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4v26 | TF3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4v26 | TF3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 1.000 | |
| 2bu7 | TF3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.566 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.499 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.499 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.493 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.492 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.490 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.490 | |
| 1sqv | UHD | Cytochrome b | / | 0.487 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.485 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.485 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.484 | |
| 3hpq | AP5 | Adenylate kinase | / | 0.484 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.484 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.483 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.483 | |
| 1r2j | FAD | FkbI | / | 0.482 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.482 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.482 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.480 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.478 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.476 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.476 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 3eem | 53V | Uncharacterized protein | / | 0.475 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.475 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.474 | |
| 4eil | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.474 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.474 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.474 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.474 | |
| 1osv | CHC | Bile acid receptor | / | 0.473 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.473 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.472 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.472 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.472 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.472 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.472 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.472 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.471 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.471 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.471 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.471 | |
| 4l8u | 9AZ | Serum albumin | / | 0.471 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.471 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.470 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.470 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.470 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.470 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.470 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.470 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.469 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.469 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.469 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.469 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.469 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.469 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.469 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.468 | |
| 2bxq | IMN | Serum albumin | / | 0.468 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.468 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.468 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.468 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.468 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.467 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.467 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.466 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.466 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1ppj | ANY | Cytochrome b | / | 0.465 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.465 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.465 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.465 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.465 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.464 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.464 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.464 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3g0e | B49 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.464 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.464 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.464 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.464 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.464 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.464 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.463 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.462 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.462 | |
| 1qax | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.462 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.462 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.462 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.462 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.462 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.462 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.461 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.461 | |
| 2hzi | JIN | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 2xvv | 9DN | Serum albumin | / | 0.461 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.461 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.461 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.461 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.461 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.461 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.461 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.461 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.460 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.460 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.460 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.460 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.460 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.460 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.459 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.459 | |
| 2jfa | RAL | Estrogen receptor | / | 0.459 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.459 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.459 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.459 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.459 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.459 | |
| 4ug2 | NGI | Adenosine receptor A2a | / | 0.459 | |
| 1ake | AP5 | Adenylate kinase | / | 0.458 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.458 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.458 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.458 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.458 | |
| 2j7p | GNP | Signal recognition particle protein | / | 0.458 | |
| 2j7p | GNP | Signal recognition particle receptor FtsY | / | 0.458 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.458 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.458 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.458 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.458 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.458 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.458 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.458 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.458 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.458 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.458 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.458 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.458 | |
| 1jx0 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.457 | |
| 1yin | CM3 | Estrogen receptor | / | 0.457 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.457 | |
| 3cwk | REA | Cellular retinoic acid-binding protein 2 | / | 0.457 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.457 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.457 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.457 | |
| 4edz | 0O5 | Hematopoietic prostaglandin D synthase | / | 0.457 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 1zdw | FLV | Prenyltransferase | / | 0.456 | |
| 2c47 | 5ID | Casein kinase I isoform gamma-2 | / | 0.456 | |
| 2j14 | GNI | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.456 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.456 | |
| 3eej | 53R | Uncharacterized protein | / | 0.456 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.456 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.456 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.456 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.456 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.456 | |
| 4wkq | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.455 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.455 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.455 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.455 | |
| 3vw8 | DF6 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.455 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.455 | |
| 4kba | 1QM | Casein kinase I isoform delta | 2.7.11.1 | 0.455 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.454 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.454 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.454 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.454 | |
| 2fyp | RDE | Endoplasmin | / | 0.454 | |
| 2ofv | 242 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.454 | |
| 2vx1 | 7X8 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.454 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.454 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.454 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.454 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.454 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.453 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.453 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1nq2 | 4HY | Thyroid hormone receptor beta | / | 0.453 | |
| 2ido | TMP | DNA polymerase III subunit epsilon | 2.7.7.7 | 0.453 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.453 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.453 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.453 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.453 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3v49 | PK0 | Androgen receptor | / | 0.453 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.453 | |
| 4kb8 | 1QN | Casein kinase I isoform delta | 2.7.11.1 | 0.453 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.453 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.452 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.452 | |
| 1qzf | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.452 | |
| 2clh | F19 | Tryptophan synthase alpha chain | / | 0.452 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.452 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.452 | |
| 3h9f | 92M | Dual specificity protein kinase TTK | 2.7.12.1 | 0.452 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 3wbf | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.452 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.452 | |
| 4h0x | NAD | Iota toxin component Ia | / | 0.452 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.452 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.452 | |
| 4phl | PIL | Phosphodiesterase | / | 0.452 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.451 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.451 | |
| 1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.451 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.451 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.451 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.451 | |
| 2q5o | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.451 | |
| 2q5o | PPY | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.451 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.451 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.451 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.451 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.451 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.451 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3uq9 | TBN | Putative adenosine kinase | / | 0.451 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.451 | |
| 4l4x | NDP | AmphI | / | 0.451 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.450 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.450 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.450 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.450 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.450 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.450 | |
| 2j0k | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.450 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.450 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.450 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.450 | |
| 2xvw | 9NR | Serum albumin | / | 0.450 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.450 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.450 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.450 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.450 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.450 | |
| 3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.450 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.450 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.450 | |
| 4kwh | NAP | Reductase homolog | / | 0.450 | |
| 5c3y | AN2 | Ribokinase | / | 0.450 | |
| 1cbs | REA | Cellular retinoic acid-binding protein 2 | / | 0.449 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.449 | |
| 1l2o | ADP | Myosin heavy chain, striated muscle | / | 0.449 | |
| 1syn | F89 | Thymidylate synthase | / | 0.449 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.449 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.449 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.449 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.449 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.449 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3mb7 | 14I | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3qly | 55V | Uncharacterized protein | / | 0.449 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.449 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.449 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 5c88 | COA | N-alpha-acetyltransferase | / | 0.449 | |
| 5es7 | FON | Linear gramicidin synthase subunit A | / | 0.449 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.448 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.448 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.448 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.448 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.448 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.448 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.448 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.448 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.448 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.448 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.448 | |
| 3eek | 53S | Uncharacterized protein | / | 0.448 | |
| 3iqe | F42 | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.448 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 4n4t | 2GV | Tankyrase-1 | 2.4.2.30 | 0.448 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.448 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.448 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.447 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1m67 | BOA | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.447 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.447 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.447 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.447 | |
| 2czf | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.447 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.447 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.447 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.447 | |
| 2p15 | EZT | Estrogen receptor | / | 0.447 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 3iqe | H4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.447 | |
| 3iw7 | IPK | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3srs | M23 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.447 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 4gyi | ADP | Uncharacterized protein | / | 0.447 | |
| 4h4y | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.447 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.447 | |
| 4jl5 | ADP | Adenylate kinase | / | 0.447 | |
| 4qvt | ACO | Acetyltransferase YpeA | 2.3.1 | 0.447 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.447 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.446 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.446 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1pl8 | NAD | Sorbitol dehydrogenase | 1.1.1.14 | 0.446 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.446 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.446 | |
| 1uum | AFI | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.446 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.446 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.446 | |
| 3jw3 | TOP | Dihydrofolate reductase | / | 0.446 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.446 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.446 | |
| 4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.446 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.446 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.446 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.446 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.446 | |
| 1bcp | ATP | Pertussis toxin subunit 4 | / | 0.445 | |
| 1bcp | ATP | Pertussis toxin subunit 5 | / | 0.445 | |
| 1e0a | GNP | Cell division control protein 42 homolog | / | 0.445 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 1ori | SAH | Protein arginine N-methyltransferase 1 | / | 0.445 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.445 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.445 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.445 | |
| 2owv | SAH | Diphthine synthase | / | 0.445 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.445 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.445 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 4af3 | VX6 | Aurora kinase B | 2.7.11.1 | 0.445 | |
| 4ajw | VWN | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.7.1.153 | 0.445 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.445 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.445 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.445 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.445 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.445 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.445 | |
| 4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.445 | |
| 5a3b | APR | SIR2 family protein | / | 0.445 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.445 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.445 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.445 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1g69 | TZP | Thiamine-phosphate synthase | / | 0.444 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.444 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 1lfd | GNP | GTPase HRas | / | 0.444 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2gpu | OHT | Estrogen-related receptor gamma | / | 0.444 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.444 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 2oz6 | CMP | Cyclic AMP receptor-like protein | / | 0.444 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.444 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.444 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.444 | |
| 3a7d | FBN | Catechol O-methyltransferase | 2.1.1.6 | 0.444 | |
| 3d8x | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.444 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.444 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.444 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.444 | |
| 3r37 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.444 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.444 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.444 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 4a9n | A9N | Bromodomain-containing protein 2 | / | 0.444 | |
| 4c67 | L5S | Bromodomain-containing protein 4 | / | 0.444 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.444 | |
| 4e8y | IHA | D-beta-D-heptose 7-phosphate kinase | / | 0.444 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.444 | |
| 4g16 | 0VM | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.444 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.444 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.444 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.444 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.444 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.444 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 4z44 | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.444 | |
| 5a3c | NAD | SIR2 family protein | / | 0.444 | |
| 5f2k | SAH | Uncharacterized protein | / | 0.444 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.444 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.443 | |
| 1bq1 | CB3 | Thymidylate synthase | / | 0.443 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2btd | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.443 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.443 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.443 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.443 | |
| 3bhr | THG | Thymidylate synthase | / | 0.443 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3eel | 53T | Uncharacterized protein | / | 0.443 | |
| 3hl7 | I47 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.443 | |
| 3r34 | COA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.443 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.443 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.443 | |
| 4k9n | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.443 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.443 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 1fnn | ADP | ORC1-type DNA replication protein | / | 0.442 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.442 | |
| 1nav | IH5 | Thyroid hormone receptor alpha | / | 0.442 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.442 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.442 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.442 | |
| 2bxm | IMN | Serum albumin | / | 0.442 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.442 | |
| 2hbh | XE4 | Vitamin D3 receptor A | / | 0.442 | |
| 2j5s | KTA | Alr4455 protein | / | 0.442 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.442 | |
| 2mm3 | CHO | Gastrotropin | / | 0.442 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 2wpw | ACO | Orf14 | / | 0.442 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2ynf | WHU | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 3ez2 | ADP | Plasmid partition protein A | / | 0.442 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3hp5 | 52P | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.442 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.442 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.442 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3v1u | HXC | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.442 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.442 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.442 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.442 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.442 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.441 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1sqp | MYX | Cytochrome b | / | 0.441 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1td2 | PXL | Pyridoxal kinase PdxY | / | 0.441 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.441 | |
| 1ysx | 4EB | Serum albumin | / | 0.441 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.441 | |
| 2ds1 | 1CD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2f2c | AP9 | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.441 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.441 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.441 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.441 | |
| 2pv7 | NAD | T-protein | 1.3.1.12 | 0.441 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.441 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.441 | |
| 3iw5 | DF3 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3l71 | AZO | Cytochrome b | / | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.441 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3zuy | TCH | Transporter | / | 0.441 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.441 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.441 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 4men | 25K | Bromodomain-containing protein 4 | / | 0.441 | |
| 4utd | ACP | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 5jqb | IBP | Envelope glycoprotein | / | 0.441 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.441 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.440 | |
| 1mq4 | ADP | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.440 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.440 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.440 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.440 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.440 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ysi | N3B | Bcl-2-like protein 1 | / | 0.440 | |
| 2egl | SAH | Diphthine synthase | / | 0.440 | |
| 2f4j | VX6 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.440 | |
| 2hvc | LGD | Androgen receptor | / | 0.440 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.440 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2yiu | SMA | Cytochrome b | / | 0.440 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.440 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.440 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.440 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.440 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.440 | |
| 3l8x | N4D | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3okx | SAM | S-adenosyl-L-methionine-binding protein RPA0152 | / | 0.440 | |
| 3tam | M06 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.440 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.440 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.440 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.440 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.440 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.440 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4l9q | 9TP | Serum albumin | / | 0.440 | |
| 4loo | SB4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4lv7 | ADP | Inositol-pentakisphosphate 2-kinase | 2.7.1.158 | 0.440 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 4uga | Q05 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.440 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.440 |