sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4uya	AGS	Mitogen-activated protein kinase kinase kinase 21	2.7.11.25

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4uya	AGS	Mitogen-activated protein kinase kinase kinase 21	2.7.11.25	1.000
3qlf	PD5	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.504
4dgg	I76	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.476
3l8p	0CE	Angiopoietin-1 receptor	2.7.10.1	0.459
2c0i	L1G	Tyrosine-protein kinase HCK	2.7.10.2	0.454
5br4	NAD	Lactaldehyde reductase	1.1.1.77	0.453
3b6z	CO7	Enoyl reductase LovC	1	0.445
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.443
4nka	2K7	Fibroblast growth factor receptor 1	/	0.442