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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4utkFNRXenobiotic reductase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4utkFNRXenobiotic reductase/1.000
4utlFNRXenobiotic reductase/0.686
3n19FNRXenobiotic reductase/0.613
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.567
3l5lFMNXenobiotic reductase/0.559
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.551
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.545
1icqFMN12-oxophytodienoate reductase 11.3.1.420.540
3p74FMNPentaerythritol tetranitrate reductase/0.538
2q3oFMN12-oxophytodienoate reductase 31.3.1.420.534
1vyrFMNPentaerythritol tetranitrate reductase/0.530
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.529
1icpFMN12-oxophytodienoate reductase 11.3.1.420.520
1h50FMNPentaerythritol tetranitrate reductase/0.513
1z44FMNNADPH dehydrogenase/0.510
3p84FMNPentaerythritol tetranitrate reductase/0.508
3p8jFMNPentaerythritol tetranitrate reductase/0.508
1h63FMNPentaerythritol tetranitrate reductase/0.503
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.503
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.499
4uthFMNXenobiotic reductase/0.499
3f03FMNPentaerythritol tetranitrate reductase/0.497
4tmbFMNOld yellow enzyme/0.490
1z41FMNNADPH dehydrogenase/0.482
2abbFMNPentaerythritol tetranitrate reductase/0.481
2gouFMNNADH:flavin oxidoreductase Sye1/0.480
1q45FMN12-oxophytodienoate reductase 31.3.1.420.473
1kbiFMNCytochrome b2, mitochondrial1.1.2.30.467
2zs9ADPPantothenate kinase2.7.1.330.464
3n14FMNXenobiotic reductase/0.464
3p82FMNPentaerythritol tetranitrate reductase/0.463
3p8iFMNPentaerythritol tetranitrate reductase/0.463
2j6xFMNLactate oxidase/0.462
1v0jFADUDP-galactopyranose mutase5.4.99.90.460
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.458
4jicFMNGTN Reductase/0.457
4awtFMNNADH:flavin oxidoreductase Sye1/0.455
4m5pFMNNADPH dehydrogenase/0.455
2h8xFMNXenA/0.453
4ycpFMNtRNA-dihydrouridine(16) synthase/0.452
1oycFMNNADPH dehydrogenase 11.6.99.10.451
2vkeTACTetracycline repressor protein class D/0.451
3atzFMNProstaglandin F2a synthase/0.451
3gr8FMNNADPH dehydrogenase/0.451
3tqhNDPQuinone oxidoreductase/0.449
2e77FMNLactate oxidase/0.448
5cpmFNRNADH:flavin oxidoreductase/0.448
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.447
4rnxFMNNADPH dehydrogenase 11.6.99.10.447
4h6kFMNNADPH dehydrogenase 11.6.99.10.446
3kruFMNNADH:flavin oxidoreductase/NADH oxidase/0.444
2xpwOTCTetracycline repressor protein class D/0.443
3gkaFMNN-ethylmaleimide reductase/0.442
2ejzSAHDiphthine synthase/0.441
2qbuSAHPrecorrin-2 methyltransferase/0.441
2wn6NDPADP-ribosyltransferase enzymatic component/0.441
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.441
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.440
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.440
4bf9FMNtRNA-dihydrouridine(16) synthase/0.440