sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4u7t	SAH	DNA (cytosine-5)-methyltransferase 3A	2.1.1.37

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4u7t	SAH	DNA (cytosine-5)-methyltransferase 3A	2.1.1.37	1.000
4h0n	SAH	Dnmt2	/	0.485
3qv2	SAH	5-cytosine DNA methyltransferase	/	0.484
1mht	SAH	Modification methylase HhaI	2.1.1.37	0.454
4da4	SAH	DNA (cytosine-5)-methyltransferase 1	2.1.1.37	0.451
4wxx	SAH	DNA (cytosine-5)-methyltransferase 1	2.1.1.37	0.451
7mht	SAH	Modification methylase HhaI	2.1.1.37	0.445
3pt6	SAH	DNA (cytosine-5)-methyltransferase 1	2.1.1.37	0.442
4onj	SFG	DNA methyltransferase	/	0.442
8mht	SAH	Modification methylase HhaI	2.1.1.37	0.442