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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.635
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.612
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.608
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.571
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.548
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.536
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.517
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.509
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.501
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.495
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
1disBDMDihydrofolate reductase1.5.1.30.454
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2zb8IMNProstaglandin reductase 21.3.1.480.444
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.443
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
5k2dZMAAdenosine receptor A2a/0.442
4j6cSTRCytochrome P450 monooxygenase/0.441
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440