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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.668
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.633
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.606
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.587
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.583
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.578
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.547
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.546
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.536
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.536
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.516
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.481
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.481
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.480
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.475
1fmjRTLRetinol dehydratase/0.471
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.463
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.462
1zsnTN2Enoyl-ACP reductase/0.462
2x9dITCTetracycline repressor protein class D/0.461
3pwhZMAAdenosine receptor A2a/0.461
1fmlRTLRetinol dehydratase/0.460
1jioDEB6-deoxyerythronolide B hydroxylase/0.460
1og5SWFCytochrome P450 2C9/0.458
1x8lOXRRetinol dehydratase/0.458
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.457
5bp9SAHPutative methyltransferase protein/0.457
1disBDMDihydrofolate reductase1.5.1.30.455
1jpaANPEphrin type-B receptor 22.7.10.10.454
1nytNAPShikimate dehydrogenase (NADP(+))/0.454
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.453
1k6cMK1Gag-Pol polyprotein3.4.23.160.452
4j6cSTRCytochrome P450 monooxygenase/0.452
1dz4CAMCamphor 5-monooxygenase1.14.15.10.451
2ydoADNAdenosine receptor A2a/0.450
5k2dZMAAdenosine receptor A2a/0.450
4d7eFADPutative lysine-N-oxygenase/0.449
4jx1CAMCamphor 5-monooxygenase1.14.15.10.449
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2rabNADGlutathione amide reductase/0.448
3bfb9ODPheromone-binding protein ASP1/0.448
4b4w9L9Bifunctional protein FolD/0.448
1pkfEPDEpothilone C/D epoxidase1.140.447
1q5dEPBEpothilone C/D epoxidase1.140.447
2c7xNRBCytochrome P450 monooxygenase PikC/0.447
2gjlFMNNitronate monooxygenase1.13.12.160.447
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4eevL1XHepatocyte growth factor receptor2.7.10.10.447
1re9DSOCamphor 5-monooxygenase1.14.15.10.446
2bxmIMNSerum albumin/0.446
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4j6dTESCytochrome P450 monooxygenase/0.446
1ae1NAPTropinone reductase 1/0.445
1diuBDMDihydrofolate reductase1.5.1.30.445
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.444
1bveDMPGag-Pol polyprotein3.4.23.160.443
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4kwi1TJReductase homolog/0.443
1rp7TZDPyruvate dehydrogenase E1 component1.2.4.10.442
1zgaHMKIsoflavone 4'-O-methyltransferase/0.442
3ctj320Hepatocyte growth factor receptor2.7.10.10.442
3gwfFADCyclohexanone monooxygenase/0.442
3kpkFADSulfide-quinone reductase/0.442
3p6nDSOCamphor 5-monooxygenase1.14.15.10.442
4jbtASDCytochrome P450 monooxygenase/0.442
4tuvCPZCytochrome P450 1191.140.442
5i2hAGIO-methyltransferase family 2/0.442
5uviZMAAdenosine receptor A2a/0.442
1drbMTXDihydrofolate reductase1.5.1.30.441
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.441
2xvv9DNSerum albumin/0.441
3eej53RUncharacterized protein/0.441
3h1jSMACytochrome b/0.441
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
5iu86DZAdenosine receptor A2a/0.441
1qxlFR8Adenosine deaminase3.5.4.40.440
1rywEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.440
3fne8PCEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3pqbVGPPutative oxidoreductase/0.440
3slkNDPPolyketide synthase extender module 2/0.440