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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4twpAXITyrosine-protein kinase ABL12.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4twpAXITyrosine-protein kinase ABL12.7.10.21.000
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.513
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.10.478
3fkoFKOMitogen-activated protein kinase 14/0.477
4gmy0X5Tyrosine-protein kinase JAK2/0.468
4af3VX6Aurora kinase B2.7.11.10.456
4e4m0NHTyrosine-protein kinase JAK2/0.455
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.453
3fknFKNMitogen-activated protein kinase 14/0.450
4jia1K3Tyrosine-protein kinase JAK2/0.449
4qmpDKISerine/threonine-protein kinase 242.7.11.10.449
4hvi19STyrosine-protein kinase JAK32.7.10.20.447
4hvh19RTyrosine-protein kinase JAK32.7.10.20.446
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.445