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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tlbAGSCircadian clock protein kinase KaiC2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4tlbAGSCircadian clock protein kinase KaiC2.7.11.11.000
4tlcAGSCircadian clock protein kinase KaiC2.7.11.10.615
4tl9AGSCircadian clock protein kinase KaiC2.7.11.10.597
4tl7ATPCircadian clock protein kinase KaiC2.7.11.10.595
3s1aATPCircadian clock protein kinase KaiC2.7.11.10.578
4tl6ANPCircadian clock protein kinase KaiC2.7.11.10.571
4tldAGSCircadian clock protein kinase KaiC2.7.11.10.571
4tleAGSCircadian clock protein kinase KaiC2.7.11.10.563
3jzmATPCircadian clock protein kinase KaiC2.7.11.10.544
1tf7ATPCircadian clock protein kinase KaiC2.7.11.10.534
1u9iATPCircadian clock protein kinase KaiC2.7.11.10.533
4o0mATPCircadian clock protein kinase KaiC2.7.11.10.533
2gblATPCircadian clock protein kinase KaiC2.7.11.10.531
4tl8AGSCircadian clock protein kinase KaiC2.7.11.10.525
4tlaADPCircadian clock protein kinase KaiC2.7.11.10.514