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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4rrlA3SProbable threonine--tRNA ligase 26.1.1.3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
4rrlA3SProbable threonine--tRNA ligase 26.1.1.31.000
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.652
4rr6A3SProbable threonine--tRNA ligase 26.1.1.30.650
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.649
4rrbA3TProbable threonine--tRNA ligase 26.1.1.30.644
4rr8A3SProbable threonine--tRNA ligase 26.1.1.30.635
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.635
4rrdA3TProbable threonine--tRNA ligase 26.1.1.30.628
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.624
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.616
4rr9A3SProbable threonine--tRNA ligase 26.1.1.30.613
4rrcA3TProbable threonine--tRNA ligase 26.1.1.30.609
2hl0A3SThreonine--tRNA ligase6.1.1.30.591
4rrjA3SProbable threonine--tRNA ligase 26.1.1.30.590
4rrkA3TProbable threonine--tRNA ligase 26.1.1.30.577
3pd2A3SThreonine--tRNA ligase6.1.1.30.574
3pd3A3TThreonine--tRNA ligase6.1.1.30.574
2hl2SSAThreonine--tRNA ligase6.1.1.30.550
4rrqA3SThreonine--tRNA ligase6.1.1.30.543
4rrrA3TThreonine--tRNA ligase6.1.1.30.543
2hl1A3SThreonine--tRNA ligase6.1.1.30.538
4rrgA3TThreonine--tRNA ligase6.1.1.30.537
4qzuRTLRetinol-binding protein 2/0.536
3pd4A3GThreonine--tRNA ligase6.1.1.30.525
4rrfA3SThreonine--tRNA ligase6.1.1.30.520
3w0yDS4Vitamin D3 receptor/0.515
3w0gW07Vitamin D3 receptor/0.513
1pdhFASp-hydroxybenzoate hydroxylase/0.499
1crbRTLRetinol-binding protein 1/0.496
1rq1FADEndoplasmic oxidoreductin-11.8.40.496
3pd5TSBThreonine--tRNA ligase6.1.1.30.496
2hamC33Vitamin D3 receptor/0.495
2hasC3OVitamin D3 receptor/0.495
3w0hW12Vitamin D3 receptor/0.495
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.494
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.491
3junAKDPhenazine biosynthesis protein A/B/0.490
3h3t16HCollagen type IV alpha-3-binding protein/0.489
4iteTEYVitamin D3 receptor/0.489
1kquBR4Phospholipase A2, membrane associated/0.487
1fmjRTLRetinol dehydratase/0.486
2g1n1IGRenin3.4.23.150.486
5h8tRTLRetinol-binding protein 1/0.486
3a783EVVitamin D3 receptor/0.484
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.484
1txiTX5Vitamin D3 receptor/0.483
1rp4FADEndoplasmic oxidoreductin-11.8.40.482
3djfBC3Purine nucleoside phosphorylase/0.482
3v0p4GWHisto-blood group ABO system transferase/0.482
4obuPLPPyridoxal-dependent decarboxylase domain protein/0.481
4xz3COAAcyl-CoA synthetase (NDP forming)/0.481
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.480
3atzFMNProstaglandin F2a synthase/0.480
3w0iO11Vitamin D3 receptor/0.480
2hb7O1CVitamin D3 receptor/0.479
2ociTYCValacyclovir hydrolase3.10.479
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.479
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.478
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.478
3ibqATPPyridoxal kinase/0.478
3w5q3KLVitamin D3 receptor/0.478
4ead0NPThymidine phosphorylase2.4.2.40.478
4r81FMNPredicted NADH dehydrogenase/0.478
1dr3TAPDihydrofolate reductase1.5.1.30.477
2hk9NAPShikimate dehydrogenase (NADP(+))/0.477
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.477
4nbiD3YD-tyrosyl-tRNA(Tyr) deacylase/0.477
1pd9CO4Dihydrofolate reductase1.5.1.30.476
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
3up3XCAaceDAF-12/0.476
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.475
2v59LZKBiotin carboxylase6.3.4.140.475
3br3ETHTH-type transcriptional regulator QacR/0.475
3p74FMNPentaerythritol tetranitrate reductase/0.475
4g2i0VQVitamin D3 receptor/0.475
4itfTFYVitamin D3 receptor/0.475
3v1s0LHStrictosidine synthase4.3.3.20.474
2abbFMNPentaerythritol tetranitrate reductase/0.473
1dr3HBIDihydrofolate reductase1.5.1.30.472
1mrqSTRAldo-keto reductase family 1 member C1/0.472
3w5p4OAVitamin D3 receptor/0.472
2po7CHDFerrochelatase, mitochondrial4.99.1.10.471
3fsjD7KBenzoylformate decarboxylase4.1.1.70.471
3vt7VDXVitamin D3 receptor/0.471
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.471
4oztP1AEcdysone receptor, putative/0.471
3emlZMAAdenosine receptor A2a/0.471
3w0c6DSVitamin D3 receptor/0.470
4c02TAKActivin receptor type-12.7.11.300.470
4xymCOAAcyl-CoA synthetase (NDP forming)/0.470
4yekTHMThymidine phosphorylase/0.470
1rjkVDZVitamin D3 receptor/0.469
3vt45YIVitamin D3 receptor/0.469
1opbRETRetinol-binding protein 2/0.468
1svlADPLarge T antigen3.6.40.468
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.468
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.468
3w0aDS5Vitamin D3 receptor/0.468
1pq944BOxysterols receptor LXR-beta/0.467
1x8lOXRRetinol dehydratase/0.467
3w5rLOAVitamin D3 receptor/0.467
4jxrACOAcetyltransferase/0.467
4rujVDXVitamin D3 receptor A/0.467
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.466
3w0jT08Vitamin D3 receptor/0.466
4enhFVXCholesterol 24-hydroxylase/0.466
4fhi0S4Vitamin D3 receptor A/0.466
4lsjLSJGlucocorticoid receptor/0.466
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.466
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3h3qH13Collagen type IV alpha-3-binding protein/0.465
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.465
3vrvYSDVitamin D3 receptor/0.465
4y1bNAPAntE/0.465
5c4fUPGHisto-blood group ABO system transferase/0.465
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.464
2fhnBNIAvidin-related protein 4/5/0.464
2rg5279Mitogen-activated protein kinase 14/0.464
2v2zADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.464
3i0pNADMalate dehydrogenase, putative/0.464
3w5tLHPVitamin D3 receptor/0.464
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.464
4jbtASDCytochrome P450 monooxygenase/0.464
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.463
2p5uNADUDP-glucose 4-epimerase/0.463
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.463
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
3gkaFMNN-ethylmaleimide reductase/0.463
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
3v0m5GWHisto-blood group ABO system transferase/0.463
4twnB96Ephrin type-A receptor 32.7.10.10.463
5eccNAPDehydrofolate reductase type I/0.463
1bwlFMNNADPH dehydrogenase 11.6.99.10.462
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.462
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.462
1kkq471Peroxisome proliferator-activated receptor alpha/0.462
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3m13FADMonomeric sarcosine oxidase1.5.3.10.462
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3rfxNADUronate dehydrogenase/0.462
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.462
4wxfPLGSerine hydroxymethyltransferase/0.462
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.461
3m31FADEndoplasmic oxidoreductin-11.8.40.461
3ndjJHZMethyltransferase/0.461
3rthRTHBeta-secretase 13.4.23.460.461
4eiyZMAAdenosine receptor A2a/0.461
1hb1OCVIsopenicillin N synthase1.21.3.10.460
1ie9VDXVitamin D3 receptor/0.460
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.460
1pl6572Sorbitol dehydrogenase1.1.1.140.460
1s0zEB1Vitamin D3 receptor/0.460
1upw444Oxysterols receptor LXR-beta/0.460
2bxqIMNSerum albumin/0.460
2rgoFADAlpha-Glycerophosphate Oxidase/0.460
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.460
2xf3J01Uncharacterized protein/0.460
2ym1FADPhenylacetone monooxygenase1.14.13.920.460
3nga3NGCasein kinase II subunit alpha2.7.11.10.460
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.460
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.460
4j6cSTRCytochrome P450 monooxygenase/0.460
5fsxADPUncharacterized protein/0.460
1kqwRTLCellular retinol-binding protein type II/0.459
1kzjCB3Thymidylate synthase/0.459
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.459
2rhrEMOPutative ketoacyl reductase1.3.10.459
2zlcVDXVitamin D3 receptor/0.459
3h3sH15Collagen type IV alpha-3-binding protein/0.459
3kpzZNEVitamin D3 receptor/0.459
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.459
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
3v0o4GWHisto-blood group ABO system transferase/0.459
3vt3VDXVitamin D3 receptor/0.459
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.459
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.459
5iu86DZAdenosine receptor A2a/0.459
2ab2SNLMineralocorticoid receptor/0.458
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.458
2vqbFADPutative flavin-containing monooxygenase/0.458
3gwfFADCyclohexanone monooxygenase/0.458
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.458
3nmpPYVAbscisic acid receptor PYL2/0.458
3q43D66M1 family aminopeptidase3.4.110.458
4pnmNU1Tankyrase-22.4.2.300.458
4zu44TGWxcM-like protein/0.458
1dr2TAPDihydrofolate reductase1.5.1.30.457
1g8oU5PN-acetyllactosaminide alpha-1,3-galactosyltransferase/0.457
1ie8KH1Vitamin D3 receptor/0.457
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.457
1nzdUPGDNA beta-glucosyltransferase/0.457
1rszDIHPurine nucleoside phosphorylase2.4.2.10.457
2hb8MVDVitamin D3 receptor/0.457
2i4qUA4Renin3.4.23.150.457
2tpsTPSThiamine-phosphate synthase/0.457
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.457
3dhbC6LN-acyl homoserine lactonase AiiA3.1.1.810.457
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3zkyWT4Isopenicillin N synthase1.21.3.10.457
4g1z0VPVitamin D3 receptor A/0.457
4jq3ZOMAldo-keto reductase family 1 member C2/0.457
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.457
1nhz486Glucocorticoid receptor/0.456
2iviACWIsopenicillin N synthase1.21.3.10.456
3jpuTY4Transcriptional activator protein LasR/0.456
3mdvCL6Cholesterol 24-hydroxylase/0.456
3vtdTKDVitamin D3 receptor/0.456
4du82P0Mevalonate diphosphate decarboxylase/0.456
4fxy0W2Neurolysin, mitochondrial3.4.24.160.456
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.456
2harOCCVitamin D3 receptor/0.455
2w6oOA3Biotin carboxylase6.3.4.140.455
2wedPP6Penicillopepsin-13.4.23.200.455
3atyFMNProstaglandin F2a synthase/0.455
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
4awp99AHeat shock protein HSP 90-alpha/0.455
4g67SAHUncharacterized ACR, COG1565 superfamily/0.455
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.455
4kc4WS3Histo-blood group ABO system transferase/0.455
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.454
1booSAHModification methylase PvuII2.1.1.1130.454
1rkhVD2Vitamin D3 receptor/0.454
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
1vyrFMNPentaerythritol tetranitrate reductase/0.454
2bp1NDPAflatoxin B1 aldehyde reductase member 2/0.454
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.454
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.454
2xuoTZ4Acetylcholinesterase3.1.1.70.454
3biy01KHistone acetyltransferase p300/0.454
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3fp0FP015-O-acetyltransferase/0.454
3qt62P0Mevalonate diphosphate decarboxylase/0.454
3r5yF42Uncharacterized protein/0.454
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.454
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4ienCOAPutative acyl-CoA hydrolase/0.454
4la1FADThioredoxin glutathione reductase/0.454
4mwhATPCasein kinase II subunit alpha2.7.11.10.454
4q0kGA3Phytohormone-binding protein/0.454
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.454
5k2cZMAAdenosine receptor A2a/0.454
3sn6P0GBeta-2 adrenergic receptor/0.454
1a59COA2-methylcitrate synthase/0.453
1pw1HELD-alanyl-D-alanine carboxypeptidase3.4.16.40.453
1vi2NADQuinate/shikimate dehydrogenase/0.453
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
2c2aADPSensor histidine kinase/0.453
2ea2F77Methionine aminopeptidase 2/0.453
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.453
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.453
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.453
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.453
2zl9VDAVitamin D3 receptor/0.453
3da24MDCarbonic anhydrase 134.2.1.10.453
3k8q22APurine nucleoside phosphorylase2.4.2.10.453
3nxxNDPDihydrofolate reductase1.5.1.30.453
3phiNDPShikimate dehydrogenase (NADP(+))/0.453
1c7oPPGHemolysin/0.452
1qorNDPQuinone oxidoreductase 1/0.452
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.452
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.452
2hxzH7JCathepsin S3.4.22.270.452
3akn11DFatty acid-binding protein, intestinal/0.452
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.452
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.452
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.452
3sfh1DIHistone deacetylase 83.5.1.980.452
3vruYS3Vitamin D3 receptor/0.452
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.452
4i6gFADCryptochrome-2/0.452
4l5b1UXDeoxycytidine kinase2.7.1.740.452
4tmcFMNOld yellow enzyme/0.452
1bwsNDPGDP-L-fucose synthase/0.451
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.451
1oycFMNNADPH dehydrogenase 11.6.99.10.451
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1ywgNADGlyceraldehyde-3-phosphate dehydrogenase/0.451
3h3r14HCollagen type IV alpha-3-binding protein/0.451
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.451
3n6uTSUHTH-type transcriptional regulator TsaR/0.451
3ohh3HHBeta-secretase 13.4.23.460.451
3p8jFMNPentaerythritol tetranitrate reductase/0.451
3qls55VDihydrofolate reductase1.5.1.30.451
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.451
4g95OAGDihydrofolate reductase1.5.1.30.451
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.451
1diuBDMDihydrofolate reductase1.5.1.30.450
1eupASD6-deoxyerythronolide B hydroxylase/0.450
1f5fDHTSex hormone-binding globulin/0.450
1phhFADp-hydroxybenzoate hydroxylase/0.450
1ppjANYCytochrome b/0.450
1r2jFADFkbI/0.450
1rk3VDXVitamin D3 receptor/0.450
2an9GDPGuanylate kinase2.7.4.80.450
2g1y5IGRenin3.4.23.150.450
2hcdBIVVitamin D3 receptor A/0.450
2pncCLUPrimary amine oxidase, liver isozyme/0.450
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.450
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.450
3hk1B64Fatty acid-binding protein, adipocyte/0.450
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.450
3oafOAGDihydrofolate reductase1.5.1.30.450
3vv0KH3Histone-lysine N-methyltransferase SETD72.1.1.430.450
4g2h0VQVitamin D3 receptor A/0.450
4mv8ACPBiotin carboxylase6.3.4.140.450
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.450
1g63FMNEpidermin decarboxylase4.1.10.449
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1txtCAAHMG-CoA synthase/0.449
1upcTPPN(2)-(2-carboxyethyl)arginine synthase/0.449
1v93FADMethylenetetrahydrofolate reductase/0.449
2gjnFMNNitronate monooxygenase1.13.12.160.449
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.449
2q9fC3SCholesterol 24-hydroxylase/0.449
2xlpFADPutative flavin-containing monooxygenase/0.449
2xvv9DNSerum albumin/0.449
2zevIPEGeranylgeranyl pyrophosphate synthase/0.449
3b9lAZZSerum albumin/0.449
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.449
3i0aDBHNeutrophil gelatinase-associated lipocalin/0.449
3p82FMNPentaerythritol tetranitrate reductase/0.449
3qdd94MHeat shock protein HSP 90-alpha/0.449
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3qwbNDPProbable quinone oxidoreductase1.6.5.50.449
3zoiM2WIsopenicillin N synthase1.21.3.10.449
4e2bFMNDehydrogenase/0.449
4g20484Vitamin D3 receptor A/0.449
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
4lngJANCaaX farnesyltransferase beta subunit Ram1/0.449
4s0vSUVOrexin receptor type 2/0.449
1bnnAL1Carbonic anhydrase 24.2.1.10.448
1dr5NAPDihydrofolate reductase1.5.1.30.448
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
1rx8FOLDihydrofolate reductase1.5.1.30.448
1swtBTNStreptavidin/0.448
1tehNADAlcohol dehydrogenase class-31.1.1.10.448
2a4nCOAAac(6')-Ii protein/0.448
2cekN8TAcetylcholinesterase3.1.1.70.448
2o4jVD4Vitamin D3 receptor/0.448
2oaxSNLMineralocorticoid receptor/0.448
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.448
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.448
3fhxPLPPyridoxal kinase2.7.1.350.448
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.448
3gqvNAPEnoyl reductase LovC10.448
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.448
3rbqGLY_ALA_GLY_ALA_DAOProtein unc-119 homolog A/0.448
3sfxJANUncharacterized protein/0.448
3zsyOM3Integrase/0.448
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.448
4bfxZVXPantothenate kinase2.7.1.330.448
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.448
4e2dFMNDehydrogenase/0.448
4g1y0VOVitamin D3 receptor A/0.448
4kf1HT5Aryldialkylphosphatase3.1.8.10.448
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.448
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.448
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.448
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.448
1d2sDHTSex hormone-binding globulin/0.447
1drhNAPDihydrofolate reductase1.5.1.30.447
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1s5kCOAAminoglycoside N(6')-acetyltransferase type 1/0.447
1xmmM7Gm7GpppX diphosphatase3.6.1.590.447
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2abi1CAMineralocorticoid receptor/0.447
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2hc4VDXVitamin D3 receptor A/0.447
2ovhAS0Progesterone receptor/0.447
2zbaZBATrichothecene 3-O-acetyltransferase/0.447
3a1l2CCCytochrome P450/0.447
3inrGDUUDP-galactopyranose mutase5.4.99.90.447
3k4nFADPyranose 2-oxidase/0.447
3p67FMNPentaerythritol tetranitrate reductase/0.447
3vrtYS2Vitamin D3 receptor/0.447
4at0FADPossible succinate dehydrogenase/0.447
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4bgg844Activin receptor type-12.7.11.300.447
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.447
1b4pGPSGlutathione S-transferase Mu 2/0.446
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.446
1t7o152Carnitine O-acetyltransferase2.3.1.70.446
1uamSAHtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.446
1xxjUNCUricase1.7.3.30.446
1z7yAA5Cysteine synthase 12.5.1.470.446
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.446
2ctsCOACitrate synthase, mitochondrial2.3.3.10.446
2du8FADD-amino-acid oxidase1.4.3.30.446
2oazI96Methionine aminopeptidase 2/0.446
2xpc051UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.446
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
3bw4FMNPutative 2-nitropropane dioxygenase/0.446
3c16FOKAdenylate cyclase type 2/0.446
3c16FOKAdenylate cyclase type 5/0.446
3i2834NBifunctional epoxide hydrolase 23.3.2.100.446
3o0oTTPVitamin B12-dependent ribonucleotide reductase/0.446
3oibFDAPutative acyl-CoA dehydrogenase/0.446
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.446
4k5o1OTM1 family aminopeptidase3.4.110.446
4kc1WS1Histo-blood group ABO system transferase/0.446
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
4djhJDCKappa-type opioid receptor/0.446
1dirNADDihydropteridine reductase1.5.1.340.445
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.445
1rkgVD1Vitamin D3 receptor/0.445
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.445
2aa6STRMineralocorticoid receptor/0.445
2b8tTHMThymidine kinase/0.445
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.445
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2qo9ANPEphrin type-A receptor 32.7.10.10.445
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.445
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.445
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.445
3kb6NADD-lactate dehydrogenase/0.445
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3q3cNADNAD-dependent L-serine dehydrogenase/0.445
3rbqGLY_ALA_GLY_DAOProtein unc-119 homolog A/0.445
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
3ts1TYATyrosine--tRNA ligase6.1.1.10.445
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.445
3vrwYS5Vitamin D3 receptor/0.445
3vt5YI2Vitamin D3 receptor/0.445
4bj9UHBTankyrase-22.4.2.300.445
4ey6GNTAcetylcholinesterase3.1.1.70.445
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4j6bPLOCytochrome P450 monooxygenase/0.445
1eyqNARChalcone--flavonone isomerase 15.5.1.60.444
1o9bNAIQuinate/shikimate dehydrogenase/0.444
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
2bakAQZMitogen-activated protein kinase 14/0.444
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.444
2d8aNADL-threonine 3-dehydrogenase/0.444
2p9gNAID-3-phosphoglycerate dehydrogenase1.1.1.950.444
2rc4ACOHistone acetyltransferase KAT6A/0.444
2rqfJH3Hemolymph juvenile hormone binding protein/0.444
2vq7FADPutative flavin-containing monooxygenase/0.444
2xvq9DSSerum albumin/0.444
3bqdDAYGlucocorticoid receptor/0.444
3c3eGDP2-phospho-L-lactate transferase/0.444
3cgdCOACoenzyme A disulfide reductase/0.444
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3up0D7SaceDAF-12/0.444
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.444
4a9yAQZMitogen-activated protein kinase 14/0.444
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
4dymIYZActivin receptor type-12.7.11.300.444
4jtrIZPAldo-keto reductase family 1 member C2/0.444
4kc2WS2Histo-blood group ABO system transferase/0.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
5jtbZMAAdenosine receptor A2a/0.444
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.443
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.443
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.443
1s3zCOAAminoglycoside N(6')-acetyltransferase type 1/0.443
1xdpATPPolyphosphate kinase/0.443
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.443
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2cwfNDPDelta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase/0.443
2e20B4PPropionate kinase/0.443
2flhZEACytokinin-specific binding protein/0.443
2z3uCRRCytochrome P450/0.443
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.443
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
3ix4TX1Transcriptional activator protein LasR/0.443
3lqfNADGalactitol dehydrogenase/0.443
3lt2FT3Enoyl-ACP reductase/0.443
3own3OWRenin3.4.23.150.443
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.443
4bftZVTPantothenate kinase2.7.1.330.443
4cgiNZLIntegrase/0.443
4dc0NDPPutative ketoacyl reductase1.3.10.443
4fi1ATPCasein kinase II subunit alpha2.7.11.10.443
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.443
4k9oTPPBenzoylformate decarboxylase4.1.1.70.443
4kxjP34Nucleoprotein/0.443
4q71FADBifunctional protein PutA/0.443
4qmySTUSerine/threonine-protein kinase 242.7.11.10.443
5c4cUPGHisto-blood group ABO system transferase/0.443
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.443
5iubCLRAdenosine receptor A2a/0.443
1bn1AL5Carbonic anhydrase 24.2.1.10.442
1cf3FADGlucose oxidase1.1.3.40.442
1g1aNADdTDP-glucose 4,6-dehydratase/0.442
1h50FMNPentaerythritol tetranitrate reductase/0.442
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
1rx8NAPDihydrofolate reductase1.5.1.30.442
1s19MC9Vitamin D3 receptor/0.442
1zdwFLVPrenyltransferase/0.442
2amaDHTAndrogen receptor/0.442
2c9bPUG6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2hveADPNucleoside diphosphate kinase A2.7.4.60.442
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.442
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.442
2o4rVD5Vitamin D3 receptor/0.442
2p1u4TNRetinoic acid receptor RXR-alpha/0.442
2watCOAFatty acid synthase subunit alpha2.3.1.860.442
2yee2ECHeat shock protein HSP 90-alpha/0.442
3a4vNADNDP-sugar epimerase/0.442
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.442
3fznD7KBenzoylformate decarboxylase4.1.1.70.442
3q9bB3NAcetylpolyamine amidohydrolase/0.442
3tscNADUncharacterized protein/0.442
4awo99BHeat shock protein HSP 90-alpha/0.442
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.442
4bis8HQLysine-specific demethylase 4A1.14.110.442
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.442
4lsl1YQGag-Pol polyprotein2.7.7.490.442
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.442
4xldBRLPeroxisome proliferator-activated receptor gamma/0.442
5iqiGNPBifunctional AAC/APH2.3.10.442
5k2bZMAAdenosine receptor A2a/0.442
1bsvNDPGDP-L-fucose synthase/0.441
1dyjDDFDihydrofolate reductase1.5.1.30.441
1gij2PUCyclin-dependent kinase 22.7.11.220.441
1mdtAPUDiphtheria toxin/0.441
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.441
1td2PXLPyridoxal kinase PdxY/0.441
2op18PCEnoyl-ACP reductase/0.441
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.441
2rr1W8RGenome polyprotein/0.441
2vr1ATFBiotin carboxylase6.3.4.140.441
2z9dFMNFMN-dependent NADH-azoreductase/0.441
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.441
3dr1C5DVitamin D3 receptor A/0.441
3elm24FCollagenase 33.4.240.441
3ggoNAIPrephenate dehydrogenase/0.441
3hl0NADMaleylacetate reductase/0.441
3lxeTORCarbonic anhydrase 14.2.1.10.441
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.441
3p62FMNPentaerythritol tetranitrate reductase/0.441
3t37FADPyridoxine 4-oxidase/0.441
3vt9YI4Vitamin D3 receptor/0.441
3zxhE41Collagenase 33.4.240.441
4az3S35Lysosomal protective protein3.4.16.50.441
4cf1IY7Integrase/0.441
4dpuAGSMevalonate diphosphate decarboxylase/0.441
4epq0RRPoly(ADP-ribose) glycohydrolase/0.441
4imfSI3N-acetylneuraminate lyase/0.441
4mr61K0Bromodomain-containing protein 2/0.441
4q0a4OAVitamin D3 receptor A/0.441
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.441
5fwnNAPPutative dehydrogenase/0.441
1ay0TPPTransketolase 12.2.1.10.440
1ddtAPUDiphtheria toxin/0.440
1di8DTQCyclin-dependent kinase 22.7.11.220.440
1jumBERHTH-type transcriptional regulator QacR/0.440
1m4dCOAAminoglycoside 2'-N-acetyltransferase2.3.10.440
1s3uTQDDihydrofolate reductase1.5.1.30.440
1tduDURThymidylate synthase/0.440
1toiHCIAspartate aminotransferase2.6.1.10.440
1xddAAYIntegrin alpha-L/0.440
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2fpcSCGStrictosidine synthase4.3.3.20.440
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.440
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
2o12FMNChorismate synthase/0.440
2v58LZJBiotin carboxylase6.3.4.140.440
2vbpVB1Isopenicillin N synthase1.21.3.10.440
2wo7ASVIsopenicillin N synthase1.21.3.10.440
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.440
3dxmN24Actin-related protein 3/0.440
3f4bTCLEnoyl-acyl carrier protein reductase/0.440
3giyFMN(S)-mandelate dehydrogenase1.1.99.310.440
3in9H1SHeparin lyase I/0.440
3k7mFAD6-hydroxy-L-nicotine oxidase/0.440
3o6o94MHeat shock protein 83/0.440
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3orfNADDihydropteridine reductase1.5.1.340.440
3vt8YI3Vitamin D3 receptor/0.440
3wv9FEGHmd co-occurring protein HcgE/0.440
4dy4FMNNAD(P)H dehydrogenase (quinone)/0.440
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.440
4g1d0VKVitamin D3 receptor A/0.440
4h9506UDihydrofolate reductase1.5.1.30.440
4j6dTESCytochrome P450 monooxygenase/0.440
4l4eCAMCamphor 5-monooxygenase1.14.15.10.440
4o2bLOCTubulin beta-2B chain/0.440
4xbaGMPAprataxin-like protein30.440
5c3aURMHisto-blood group ABO system transferase/0.440
5c4nNAPPrecorrin-6A reductase1.3.1.540.440
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
5d7pAR6NAD-dependent protein deacetylase sirtuin-23.5.10.440
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.440