sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 1.000 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.791 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.698 | |
| 4rrb | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.690 | |
| 4rrk | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.635 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.633 | |
| 4rri | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.633 | |
| 4rr9 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.605 | |
| 4rrm | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.600 | |
| 4rrc | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.582 | |
| 4rrl | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.575 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.572 | |
| 4rr6 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.561 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.560 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.548 | |
| 2hl2 | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.548 | |
| 4rrd | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.546 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.546 | |
| 4rrj | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.543 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.541 | |
| 2hl1 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.529 | |
| 3pd5 | TSB | Threonine--tRNA ligase | 6.1.1.3 | 0.528 | |
| 4rrg | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.514 | |
| 4rrq | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.514 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.501 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.499 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.498 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.496 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.494 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.493 | |
| 3b9l | AZZ | Serum albumin | / | 0.492 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.490 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.490 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.488 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.488 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.487 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.486 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.482 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.481 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.480 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.480 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.478 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.476 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 1fml | RTL | Retinol dehydratase | / | 0.475 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.474 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.472 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.472 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.472 | |
| 4ckc | SAH | mRNA-capping enzyme catalytic subunit | 2.1.1.56 | 0.472 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.472 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.471 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.471 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.471 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.470 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.470 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.470 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.469 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.468 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.468 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.468 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.468 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.467 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.467 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.467 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.467 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.466 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.466 | |
| 2j09 | FMN | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.466 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.466 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.466 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.465 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.465 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 1c7o | PPG | Hemolysin | / | 0.464 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.464 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2xvq | 9DS | Serum albumin | / | 0.463 | |
| 2xvv | 9DN | Serum albumin | / | 0.463 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.463 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.463 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.463 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 3up3 | XCA | aceDAF-12 | / | 0.462 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.462 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.462 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.461 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 2bxq | IMN | Serum albumin | / | 0.461 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.461 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.460 | |
| 3wag | TYD | Glycosyltransferase | / | 0.460 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.460 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.459 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.459 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.459 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.459 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.459 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.459 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.458 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.458 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.458 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.458 | |
| 4fw0 | 5KJ | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.458 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.458 | |
| 1hrv | SDZ | Genome polyprotein | / | 0.457 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.457 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.457 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.457 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.457 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.457 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.457 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.457 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.456 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.456 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.456 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.456 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.456 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.456 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.456 | |
| 4o74 | R78 | Bromodomain-containing protein 4 | / | 0.456 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.456 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.455 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.455 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.455 | |
| 3frk | TQP | QdtB | / | 0.455 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.455 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.455 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.455 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.455 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.454 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.454 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.454 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.454 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.454 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.454 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.454 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.454 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.453 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.453 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.453 | |
| 2bxm | IMN | Serum albumin | / | 0.453 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.453 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.453 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.453 | |
| 3kr5 | BEY | M17 leucyl aminopeptidase | / | 0.453 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.453 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.453 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.453 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.453 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.453 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.452 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.452 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.452 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3gy9 | COA | GCN5-related N-acetyltransferase | / | 0.452 | |
| 3haz | FAD | Bifunctional protein PutA | / | 0.452 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.452 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.452 | |
| 5c3j | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | / | 0.452 | |
| 5c3j | UQ1 | Succinate dehydrogenase cytochrome b560 | / | 0.452 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.451 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.451 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.451 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.451 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3svj | 4LI | Peptide deformylase | / | 0.451 | |
| 4e2b | FMN | Dehydrogenase | / | 0.451 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.451 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.450 | |
| 1pw1 | HEL | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.450 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.450 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.450 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.450 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.450 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.450 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.450 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.450 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.450 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.449 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.449 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.449 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.449 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.449 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3up0 | D7S | aceDAF-12 | / | 0.449 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.449 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.449 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.449 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.449 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.449 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1mr9 | ACO | Streptogramin A acetyltransferase | 2.3.1 | 0.448 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.448 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.448 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.448 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.448 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.448 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.447 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1ppj | ANY | Cytochrome b | / | 0.447 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.447 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.447 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.447 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.447 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.447 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3pi0 | F91 | Endothiapepsin | 3.4.23.22 | 0.447 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.447 | |
| 3v2u | ATP | Protein GAL3 | / | 0.447 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 1e3l | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.446 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.446 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 2np8 | CC3 | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.446 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.446 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.446 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.446 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.446 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.446 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.446 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.445 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.445 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2nr4 | FMN | Conserved protein | / | 0.445 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.445 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.445 | |
| 3eej | 53R | Uncharacterized protein | / | 0.445 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.445 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.445 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.445 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.444 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.444 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.444 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.444 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.444 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.444 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.444 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3pbz | F02 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 3rnm | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.444 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.444 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.444 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.443 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.443 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.443 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.443 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.443 | |
| 1r2j | FAD | FkbI | / | 0.443 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.443 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.443 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2jfa | RAL | Estrogen receptor | / | 0.443 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.443 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.443 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.443 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.443 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.443 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.443 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.443 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.443 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.443 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.443 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.443 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.442 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.442 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.442 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.442 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.442 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.442 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.442 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.442 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2vfz | UPF | N-acetyllactosaminide alpha-1,3-galactosyltransferase | / | 0.442 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.442 | |
| 3m31 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.442 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.442 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 4na4 | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.442 | |
| 4nbi | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.442 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.441 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.441 | |
| 2xvw | 9NR | Serum albumin | / | 0.441 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.441 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 4b1f | KRH | Glutamate racemase | / | 0.441 | |
| 4c4o | NAD | SADH | / | 0.441 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.441 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.441 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.441 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 4n1g | CEI | Obelin | / | 0.441 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.441 | |
| 4y3q | F02 | Endothiapepsin | 3.4.23.22 | 0.441 | |
| 4y4j | LNR | Endothiapepsin | 3.4.23.22 | 0.441 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.441 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.440 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.440 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.440 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.440 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1z3c | SA8 | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.440 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.440 | |
| 2h6i | CYS_VAL_LEU_SER_GER | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.440 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2vax | CSC | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.440 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.440 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.440 | |
| 3ssm | SAH | Mycinamicin VI 2''-O-methyltransferase | / | 0.440 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.440 |