sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4rls	NAI	L-lactate dehydrogenase A chain	1.1.1.27

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4rls	NAI	L-lactate dehydrogenase A chain	1.1.1.27	1.000
4l4s	NAI	L-lactate dehydrogenase A chain	1.1.1.27	0.545
2x0i	NAI	Malate dehydrogenase	/	0.528
2a92	NAI	L-lactate dehydrogenase	/	0.494
3d4p	NAD	L-lactate dehydrogenase 1	1.1.1.27	0.470
3wsw	NAD	L-lactate dehydrogenase	/	0.464
1hyg	NAP	L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))	/	0.462
4mdh	NAD	Malate dehydrogenase, cytoplasmic	1.1.1.37	0.449
1ez4	NAD	L-lactate dehydrogenase	1.1.1.27	0.445
4i9n	1E5	L-lactate dehydrogenase A chain	1.1.1.27	0.442