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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.11.000
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.607
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.517
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.502
3w32W32Epidermal growth factor receptor2.7.10.10.487
3w33W19Epidermal growth factor receptor2.7.10.10.487
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.476
3vs3VSETyrosine-protein kinase HCK2.7.10.20.472
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.467
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.454
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.447
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.444
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.443
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.441