sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4qxm | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4qxm | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 1.000 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.592 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.577 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.576 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.570 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.564 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.554 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.548 | |
| 4bgi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.530 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.519 | |
| 4bii | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.519 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.518 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.516 | |
| 1enz | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.515 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.509 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.503 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.499 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.499 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.496 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.495 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.493 | |
| 2ohv | NHL | Glutamate racemase | / | 0.492 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.492 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.491 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.490 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.490 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.487 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.485 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.484 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.483 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.483 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.482 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.481 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.480 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.480 | |
| 4zlg | LGC | Putative b-glycan phosphorylase | / | 0.479 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.478 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.478 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.477 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.477 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.477 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.477 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.476 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.475 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.475 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.475 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.475 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.474 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.472 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.472 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.472 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.471 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.470 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.470 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.469 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.467 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.467 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.467 | |
| 3zux | TCH | Transporter | / | 0.467 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.466 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.466 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.465 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.465 | |
| 4kwh | NAP | Reductase homolog | / | 0.465 | |
| 1fml | RTL | Retinol dehydratase | / | 0.464 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.464 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.464 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.463 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.463 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.463 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.463 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.463 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.463 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.462 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.462 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 3k31 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4ips | 1G4 | Mycocyclosin synthase | 1.14.21.9 | 0.461 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.461 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.460 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.460 | |
| 5a3c | NAD | SIR2 family protein | / | 0.460 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.459 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.459 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.458 | |
| 1rz0 | FAD | Phenol 2-hydroxylase component B | / | 0.458 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.458 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.458 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.457 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.457 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3lnb | COA | N-acetyltransferase family protein | / | 0.457 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4h6p | FMN | Chromate reductase | / | 0.457 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.457 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.457 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.456 | |
| 3ele | PLP | Aminotransferase | / | 0.456 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.456 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.455 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.455 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.455 | |
| 4eki | 0QK | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.455 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.455 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.455 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.455 | |
| 1ci7 | UMP | Thymidylate synthase | 2.1.1.45 | 0.454 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.454 | |
| 3dtt | NAP | NADP oxidoreductase, coenzyme F420-dependent | / | 0.454 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.454 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4ekg | 0QJ | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.454 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.454 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.454 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.453 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 3dg8 | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 3umv | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.453 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.453 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.453 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.453 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.453 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.453 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.453 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 2ejz | SAH | Diphthine synthase | / | 0.452 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.452 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.452 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.451 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.451 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.451 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.451 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.450 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.450 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.450 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.450 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.449 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.449 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4l8u | 9AZ | Serum albumin | / | 0.449 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.449 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.448 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.448 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.448 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.448 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.448 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.448 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.447 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.447 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.447 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.447 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.447 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.447 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.446 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.446 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4zp0 | DXC | Multidrug transporter MdfA | / | 0.446 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.445 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.445 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.445 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1tys | DHF | Thymidylate synthase | / | 0.445 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.445 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.445 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.445 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.445 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.445 | |
| 4ict | 1ED | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.445 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.445 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.444 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.444 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.444 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.444 | |
| 4irr | UMP | Thymidylate synthase | / | 0.444 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.444 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1o5i | NAD | 3-oxoacyl-(Acyl carrier protein) reductase | / | 0.443 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.443 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.443 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.443 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.443 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.443 | |
| 4djw | 0KP | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 3ant | S82 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3h18 | PMS | Esterase/lipase | / | 0.442 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.442 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.442 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.442 | |
| 4ddh | MS0 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.442 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4jv4 | 1OR | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.442 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.442 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.442 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.442 | |
| 1ddu | DDU | Thymidylate synthase | / | 0.441 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.441 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 3afh | GSU | Glutamate--tRNA ligase 2 | / | 0.441 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.441 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.441 | |
| 4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.441 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1wbt | WBT | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.440 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.440 | |
| 4dja | FAD | (6-4) photolyase | / | 0.440 | |
| 4e5p | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.440 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.440 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.440 |