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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4qo9627Serine/threonine-protein kinase 242.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4qo9627Serine/threonine-protein kinase 242.7.11.11.000
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.512
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.497
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.493
4qmlANPSerine/threonine-protein kinase 242.7.11.10.491
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.490
3a7hATPSerine/threonine-protein kinase 242.7.11.10.489
3op5REBSerine/threonine-protein kinase VRK12.7.11.10.489
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.485
3bqr4RBDeath-associated protein kinase 3/0.483
3c4xATPRhodopsin kinase/0.483
4l9i8PRRhodopsin kinase/0.483
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.481
2qoqANPEphrin type-A receptor 32.7.10.10.481
4ansVGHALK tyrosine kinase receptor2.7.10.10.479
2j0m4STFocal adhesion kinase 12.7.10.20.478
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.476
4jia1K3Tyrosine-protein kinase JAK2/0.475
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.472
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.470
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.470
4fv6E57Mitogen-activated protein kinase 12.7.11.240.468
1pjkANPCasein kinase II subunit alpha2.7.11.10.467
2j0lANPFocal adhesion kinase 12.7.10.20.467
2xvdAS6Ephrin type-B receptor 42.7.10.10.467
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.466
2yaaATPDeath-associated protein kinase 2/0.465
2qocANPEphrin type-A receptor 32.7.10.10.464
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.464
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.463
2x9fX9FEphrin type-B receptor 42.7.10.10.462
3w2o03PEpidermal growth factor receptor2.7.10.10.462
4gk4L90Ephrin type-A receptor 32.7.10.10.462
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.461
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2c475IDCasein kinase I isoform gamma-2/0.460
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.460
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.460
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.459
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.459
4grb0XGCasein kinase II subunit alpha2.7.11.10.459
2c6eHPMAurora kinase A2.7.11.10.458
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.457
3pxkPXKFocal adhesion kinase 12.7.10.20.456
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.455
2wxvWXVCyclin-dependent kinase 22.7.11.220.455
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.455
3begANPSRSF protein kinase 12.7.11.10.455
3my5RFZCyclin-dependent kinase 22.7.11.220.455
2qo7ANPEphrin type-A receptor 32.7.10.10.454
4btjATPTau-tubulin kinase 12.7.11.10.454
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.454
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.453
3js2VM1Fibroblast growth factor receptor 1/0.453
4b99R4LMitogen-activated protein kinase 72.7.11.240.453
2henADPEphrin type-B receptor 22.7.10.10.452
2yfxVGHALK tyrosine kinase receptor2.7.10.10.452
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.452
3e5aVX6Aurora kinase A2.7.11.10.452
3i60E86Mitogen-activated protein kinase 12.7.11.240.452
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.452
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.451
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.450
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.450
3hx4ANPCalmodulin-domain protein kinase 1/0.450
4aguD15Cyclin-dependent kinase-like 1/0.450
4wboANWRhodopsin kinase/0.450
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.449
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.449
4bchT7ZCyclin-dependent kinase 92.7.11.220.449
2hog710Serine/threonine-protein kinase Chk12.7.11.10.448
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.448
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.447
3axwTIDCasein kinase II subunit alpha2.7.11.10.447
3t8oATPRhodopsin kinase/0.447
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.447
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.446
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.446
4k8aK8AFocal adhesion kinase 12.7.10.20.446
2uzbC75Cyclin-dependent kinase 22.7.11.220.445
4c3pACPAurora kinase A2.7.11.10.444
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.444
4qmzB49Serine/threonine-protein kinase 242.7.11.10.444
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.443
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3lltANPProtein serine/threonine kinase-1/0.443
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.443
4b8mVX6Aurora kinase B-A2.7.11.10.443
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.442
3c4wATPRhodopsin kinase/0.442
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.442
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.442
2etm7PYFocal adhesion kinase 12.7.10.20.441
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.441
3zewSTUEphrin type-B receptor 42.7.10.10.440
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440