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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4qmpDKISerine/threonine-protein kinase 242.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4qmpDKISerine/threonine-protein kinase 242.7.11.11.000
2xikJ60Serine/threonine-protein kinase 252.7.11.10.531
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.527
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.521
3ggfGVDSerine/threonine-protein kinase 26/0.514
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.493
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.487
5e8wSTUTGF-beta receptor type-12.7.11.300.486
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.485
3zep1NXTyrosine-protein kinase JAK32.7.10.20.477
2iw84SPCyclin-dependent kinase 22.7.11.220.475
3rmf20ZCyclin-dependent kinase 22.7.11.220.474
3a7jADPSerine/threonine-protein kinase 242.7.11.10.467
3gxlQIGTGF-beta receptor type-12.7.11.300.466
4qms1N1Serine/threonine-protein kinase 242.7.11.10.466
3s1h56ZCyclin-dependent kinase 22.7.11.220.465
3r9dX6BCyclin-dependent kinase 22.7.11.220.464
3rak03ZCyclin-dependent kinase 22.7.11.220.464
1oi9N20Cyclin-dependent kinase 22.7.11.220.461
4qmlANPSerine/threonine-protein kinase 242.7.11.10.461
1di8DTQCyclin-dependent kinase 22.7.11.220.459
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.459
4fko20KCyclin-dependent kinase 22.7.11.220.459
4fkw62KCyclin-dependent kinase 22.7.11.220.457
2wihP48Cyclin-dependent kinase 22.7.11.220.456
2wotZZGTGF-beta receptor type-12.7.11.300.456
3ral04ZCyclin-dependent kinase 22.7.11.220.456
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.456
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.455
1g5sI17Cyclin-dependent kinase 22.7.11.220.454
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3uli1N3Cyclin-dependent kinase 22.7.11.220.454
1oiyN41Cyclin-dependent kinase 22.7.11.220.453
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3rpv26ZCyclin-dependent kinase 22.7.11.220.452
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.452
4qmzB49Serine/threonine-protein kinase 242.7.11.10.452
4fkr45KCyclin-dependent kinase 22.7.11.220.451
1vjy460TGF-beta receptor type-12.7.11.300.449
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4fx360KCyclin-dependent kinase 22.7.11.220.449
1gij2PUCyclin-dependent kinase 22.7.11.220.448
1ke9LS5Cyclin-dependent kinase 22.7.11.220.446
1w6hTITPlasmepsin-23.4.23.390.446
2eufLQQCyclin-dependent kinase 62.7.11.220.446
2xmyCDKCyclin-dependent kinase 22.7.11.220.446
3qu0X40Cyclin-dependent kinase 22.7.11.220.446
4acm7YGCyclin-dependent kinase 22.7.11.220.446
4gmy0X5Tyrosine-protein kinase JAK2/0.446
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
3qtxX43Cyclin-dependent kinase 22.7.11.220.445
1fvv107Cyclin-dependent kinase 22.7.11.220.444
1gih1PUCyclin-dependent kinase 22.7.11.220.444
3qzhX69Cyclin-dependent kinase 22.7.11.220.444
3rk507ZCyclin-dependent kinase 22.7.11.220.444
2b7aIZATyrosine-protein kinase JAK2/0.443
1xjdSTUProtein kinase C theta type2.7.11.130.442
1ke6LS2Cyclin-dependent kinase 22.7.11.220.441
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.440
3unk0BYCyclin-dependent kinase 22.7.11.220.440
4bgh3I6Cyclin-dependent kinase 22.7.11.220.440