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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ql3GDPGTPase KRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
4ql3GDPGTPase KRas/1.000
4epxGDPGTPase KRas/0.871
4q03GDPGTPase KRas/0.834
4ldjGDPGTPase KRas/0.743
4tq9GDPGTPase KRas/0.637
1x1rGDPRas-related protein M-Ras/0.607
4o2rGDPGTP-binding protein Rheb/0.600
2fe4GDPRas-related protein Rab-6B/0.593
4l9sGDPGTPase HRas/0.590
4q02GDPGTPase KRas/0.589
4l8gGDPGTPase KRas/0.580
4lpkGDPGTPase KRas/0.579
3kkqGDPRas-related protein M-Ras/0.575
4obeGDPGTPase KRas/0.570
3kkoGNPRas-related protein M-Ras/0.569
4hdqGNPRas-related protein Rap-1b/0.566
4lv6GDPGTPase KRas/0.559
4wa7GDPGTPase KRas/0.554
2rggGNPGTPase HRas/0.552
4epwGDPGTPase KRas/0.550
3pitGNPRas-related protein M-Ras/0.540
2bmeGNPRas-related protein Rab-4A/0.538
2ce2GDPGTPase HRas/0.538
4xvrGNPGTPase HRas/0.537
3ddcGNPGTPase HRas/0.536
4lrwGDPGTPase KRas/0.536
3cphGDPRas-related protein SEC4/0.535
3tgpGNPGTPase HRas/0.535
3lbhGNPGTPase HRas/0.533
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.530
4dltGNPGTPase HRas/0.530
3v4fGNPGTPase HRas/0.528
4xvqGNPGTPase HRas/0.526
1yu9GNPRas-related protein Rab-4A/0.525
2fg5GNPRas-related protein Rab-31/0.524
3oiwGNPGTPase HRas/0.522
3rs0GNPGTPase HRas/0.522
2rgbGNPGTPase HRas/0.521
3oiuGNPGTPase HRas/0.520
3l8yGNPGTPase HRas/0.518
3k9lGNPGTPase HRas/0.517
3i3sGNPGTPase HRas/0.516
4dsuGDPGTPase KRas/0.516
2c5lGTPGTPase HRas/0.513
3lbnGNPGTPase HRas/0.513
3rs4GNPGTPase HRas/0.513
3rslGNPGTPase HRas/0.513
4dsnGCPGTPase KRas/0.513
4qxaGTPRas-related protein Rab-9A/0.512
4uj3GNPRas-related protein Rab-11A/0.512
1d5cGDPGTPase (Rab6)/0.511
1zbdGTPRas-related protein Rab-3A/0.511
2mscGDPMHC class I alpha chain/0.511
2rgcGNPGTPase HRas/0.510
3x1zGNPRas-related protein Rap-1b/0.508
3a6pGTPGTP-binding nuclear protein Ran/0.507
3kudGDPGTPase HRas/0.507
3lbiGNPGTPase HRas/0.507
4dlxGNPGTPase HRas/0.506
3w3zGTPGTP-binding nuclear protein Ran/0.504
4g0nGNPGTPase HRas/0.504
3rs5GNPGTPase HRas/0.503
3x1wGDPRas-related protein Rap-1b/0.501
1n6lGTPRas-related protein Rab-5A/0.500
4dlwGNPGTPase HRas/0.500
5difGNPGTP-binding nuclear protein Ran/0.499
3k8yGNPGTPase HRas/0.498
3oivGNPGTPase HRas/0.498
1e96GTPRas-related C3 botulinum toxin substrate 1/0.497
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.497
4kgkGTPUncharacterized protein/0.497
4dlzGNPGTPase HRas/0.496
2rgeGNPGTPase HRas/0.495
1zd9GDPADP-ribosylation factor-like protein 8A/0.492
1g16GDPRas-related protein SEC4/0.490
4mitGTPRho-related protein racC/0.490
4nyjGNPGTPase HRas/0.488
5b2zGNPGTPase HRas/0.488
1z2aGDPRas-related protein Rab-23/0.487
3qbtGNPRas-related protein Rab-8A/0.487
4nyiGNPGTPase HRas/0.487
2q3fGNPRas-related GTP-binding protein D/0.486
4dsoGSPGTPase KRas/0.486
3vhxGTPADP-ribosylation factor 6/0.485
4hdoGNPRas-related protein Rap-1b/0.485
1npdNADQuinate/shikimate dehydrogenase/0.482
3rs7GNPGTPase HRas/0.482
1kmqGNPTransforming protein RhoA/0.481
4rkfGNPRas-related protein Rab-3/0.481
1lfdGNPGTPase HRas/0.480
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.480
1zc4GNPRas-related protein Ral-A/0.478
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.478
4dlvGNPGTPase HRas/0.478
4uj5GNPRas-related protein Rab-11A/0.477
1d6w00RProthrombin3.4.21.50.476
1oixGDPRas-related protein Rab-11A/0.476
2cl6CAGGTPase HRas/0.476
3kucGDPRas-related protein Rap-1A/0.476
3cobADPKinesin heavy chain-like protein/0.475
3t4eNADQuinate/shikimate dehydrogenase/0.475
3vv8B02Beta-secretase 13.4.23.460.475
1z0dGDPRas-related protein Rab-5C/0.474
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.474
4dlsGNPGTPase HRas/0.474
1k5dGNPGTP-binding nuclear protein Ran/0.473
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.473
2msdGNPMHC class I alpha chain/0.472
3lqfNADGalactitol dehydrogenase/0.472
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.472
1e0jANPDNA primase/helicase2.7.70.471
5jljGNPGTP-binding nuclear protein Ran/0.471
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.469
3n0hTOPDihydrofolate reductase1.5.1.30.469
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.469
4o2lGTPGTP-binding protein Rheb/0.469
1vyrFMNPentaerythritol tetranitrate reductase/0.468
2r2mI50Prothrombin3.4.21.50.468
1ibrGNPGTP-binding nuclear protein Ran/0.467
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.467
4p9dTMPDeoxycytidylate deaminase/0.467
1a4rGNHCell division control protein 42 homolog/0.466
1n83CLRNuclear receptor ROR-alpha/0.466
2oo7AP5Adenylate kinase/0.466
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.466
3bbpGTPRas-related protein Rab-6A/0.466
3e5hGNPRas-related protein Rab-28/0.466
4a802ANMajor pollen allergen Bet v 1-A/0.466
4a81DXCMajor pollen allergen Bet v 1-A/0.466
1s3uTQDDihydrofolate reductase1.5.1.30.465
2hu2NADC-terminal binding protein 1/0.465
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.465
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.464
3pcrGTPADP-ribosylation factor 6/0.464
4hyvPEPPyruvate kinase 12.7.1.400.464
1pd9CO4Dihydrofolate reductase1.5.1.30.463
1rd4L08Integrin alpha-L/0.463
1rszDIHPurine nucleoside phosphorylase2.4.2.10.463
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.463
4z28BTNHoefavidin/0.463
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.462
1y9dTPPPyruvate oxidase1.2.3.30.462
2a7r5GPGMP reductase 2/0.462
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.462
5dhaGNPGTP-binding nuclear protein Ran/0.462
1mewXMPInosine-5'-monophosphate dehydrogenase/0.460
2bkuGTPGTP-binding nuclear protein Ran/0.460
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.460
4f31KAIGlutamate receptor 3/0.460
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.460
3oesGNPGTPase RhebL1/0.459
3tozNADShikimate dehydrogenase (NADP(+))/0.459
4l9wGNPGTPase HRas/0.459
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.459
1hb1OCVIsopenicillin N synthase1.21.3.10.458
1xtsGTPGTP-binding protein Rheb/0.458
2bxmIMNSerum albumin/0.458
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.458
3vdqNAD3-hydroxybutyrate dehydrogenase/0.458
3wyfGTPGTP-binding nuclear protein/0.458
1pq944BOxysterols receptor LXR-beta/0.457
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.457
2c2aADPSensor histidine kinase/0.457
4q71FADBifunctional protein PutA/0.457
1ikgREXD-alanyl-D-alanine carboxypeptidase3.4.16.40.456
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.456
3vt45YIVitamin D3 receptor/0.456
1xe65FPPlasmepsin-23.4.23.390.455
1ypkCCRProthrombin3.4.21.50.455
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.455
3d84NDPDihydrofolate reductase1.5.1.30.455
3w8fNAD3-hydroxybutyrate dehydrogenase/0.455
4b7754MBeta-secretase 13.4.23.460.455
4g95OAGDihydrofolate reductase1.5.1.30.455
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.454
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.454
3b05IPEIsopentenyl-diphosphate delta-isomerase/0.454
4b0532DBeta-secretase 13.4.23.460.454
4eueNAITrans-2-enoyl-CoA reductase [NADH]/0.454
4gh5NADShort-chain dehydrogenase/reductase SDR/0.454
1dr2TAPDihydrofolate reductase1.5.1.30.453
1f5fDHTSex hormone-binding globulin/0.453
3gwdNAPCyclohexanone monooxygenase/0.453
3oafOAGDihydrofolate reductase1.5.1.30.453
3wrlCAMCamphor 5-monooxygenase1.14.15.10.453
4dbzNDPPutative ketoacyl reductase1.3.10.453
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.453
5es7FONLinear gramicidin synthase subunit A/0.453
1mvtDTMDihydrofolate reductase1.5.1.30.452
1n08ADPRiboflavin kinase2.7.1.260.452
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.452
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.452
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.452
4o25GTPGTP-binding protein Rheb/0.452
4yjdFADD-amino-acid oxidase1.4.3.30.452
1jolFFODihydrofolate reductase1.5.1.30.451
1ky2GNPGTP-binding protein YPT7/0.451
1pqc444Oxysterols receptor LXR-beta/0.451
2ok8FADFerredoxin--NADP reductase, apicoplast/0.451
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
1blzACVIsopenicillin N synthase1.21.3.10.450
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.450
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.450
1zw1TN5Enoyl-ACP reductase/0.450
2y66N04UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.450
3k7mFAD6-hydroxy-L-nicotine oxidase/0.450
4acuQN7Beta-secretase 13.4.23.460.450
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
4jauADPSensor histidine kinase/0.450
3p62FMNPentaerythritol tetranitrate reductase/0.449
4a83DXCMajor pollen allergen Bet v 1-A/0.449
2tprFADTrypanothione reductase1.8.1.120.448
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.448
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.448
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.448
3ekuCY9Actin-5C/0.448
3nxxNDPDihydrofolate reductase1.5.1.30.448
3p74FMNPentaerythritol tetranitrate reductase/0.448
4ead0NPThymidine phosphorylase2.4.2.40.448
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.448
1dr3HBIDihydrofolate reductase1.5.1.30.447
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.447
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.447
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.447
3toxNAPPutative oxidoreductase/0.447
4oqyNDP(S)-imine reductase/0.447
1hb3SCVIsopenicillin N synthase1.21.3.10.446
1m78NDPDihydrofolate reductase1.5.1.30.446
1sb1165Prothrombin3.4.21.50.446
2rewREWPeroxisome proliferator-activated receptor alpha/0.446
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
3pm1ETHTH-type transcriptional regulator QacR/0.446
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.446
4acxS8ZBeta-secretase 13.4.23.460.446
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4h9753SDihydrofolate reductase1.5.1.30.446
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.445
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2vhtATPNTPase P4/0.445
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.445
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.445
3pw8ACO1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.445
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.445
5iqiGNPBifunctional AAC/APH2.3.10.445
1dhfFOLDihydrofolate reductase1.5.1.30.444
1dr3TAPDihydrofolate reductase1.5.1.30.444
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.444
1o9bNAIQuinate/shikimate dehydrogenase/0.444
1rx4DDFDihydrofolate reductase1.5.1.30.444
1rx8FOLDihydrofolate reductase1.5.1.30.444
1vg8GNPRas-related protein Rab-7a/0.444
1yhjR6CPyridoxal kinase2.7.1.350.444
2abbFMNPentaerythritol tetranitrate reductase/0.444
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.444
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
4f5dC2EStimulator of interferon genes protein/0.444
4friDWABeta-secretase 13.4.23.460.444
4frkDWDBeta-secretase 13.4.23.460.444
4h3i10VBeta-secretase 13.4.23.460.444
4yqfGDPSeptin-9/0.444
1dr5NAPDihydrofolate reductase1.5.1.30.443
1vf2GTXGlutathione S-transferase 32.5.1.180.443
1z7yAA5Cysteine synthase 12.5.1.470.443
2j9lATPH(+)/Cl(-) exchange transporter 5/0.443
2z9dFMNFMN-dependent NADH-azoreductase/0.443
2zynBCDPeriplasmic binding protein/0.443
3gb4D3MDdmC/0.443
3gwfNAPCyclohexanone monooxygenase/0.443
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.443
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.443
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.443
4rww2BALmo2692 protein/0.443
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.443
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.443
2o2yTCLEnoyl-ACP reductase/0.442
3gy9COAGCN5-related N-acetyltransferase/0.442
3p67FMNPentaerythritol tetranitrate reductase/0.442
4a87NARMajor pollen allergen Bet v 1-A/0.442
4d0lGSPRas-related protein Rab-11A/0.442
5fm7ADPRuvB-like helicase/0.442
1eiiRTLRetinol-binding protein 2/0.441
1kt6RTLRetinol-binding protein 4/0.441
1mk1APRMutT/nudix family protein/0.441
1nw5SAMModification methylase RsrI2.1.1.720.441
2h15B19Carbonic anhydrase 24.2.1.10.441
2rqfJH3Hemolymph juvenile hormone binding protein/0.441
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.441
3aosJH2Hemolymph juvenile hormone binding protein/0.441
3kz1GSPTransforming protein RhoA/0.441
3zeiAWHO-acetylserine sulfhydrylase/0.441
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.441
1am4GNPCell division control protein 42 homolog/0.440
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.440
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1mvsDTMDihydrofolate reductase1.5.1.30.440
1tu3GNPRas-related protein Rab-5A/0.440
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2v8pCDP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
2wo7ASVIsopenicillin N synthase1.21.3.10.440
2x06NADL-sulfolactate dehydrogenase/0.440
3gonANPPhosphomevalonate kinase/0.440
3jyqNADQuinate/shikimate dehydrogenase (NAD(+))/0.440
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.440
4azy7F3Beta-secretase 13.4.23.460.440
4cidANPEH domain-containing protein 2/0.440
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
4opiFDAConserved Archaeal protein/0.440
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4y17LAETranscriptional regulator of ftsQAZ gene cluster/0.440