sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4qel | TZD | Benzoylformate decarboxylase | 4.1.1.7 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4qel | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 1.000 | |
| 1bfd | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.741 | |
| 4mzx | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.708 | |
| 4ju8 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.683 | |
| 4jd5 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.679 | |
| 4mpr | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.662 | |
| 5dgt | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.662 | |
| 2fwn | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.653 | |
| 4gm0 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.653 | |
| 4mq5 | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.647 | |
| 4ju9 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.585 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.574 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.568 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.546 | |
| 4k9p | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.542 | |
| 4juc | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.537 | |
| 4gm1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.507 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.503 | |
| 1iy8 | NAD | Levodione reductase | / | 0.498 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.494 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.488 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.487 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.485 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.483 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.483 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.483 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.482 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.482 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.481 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.481 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.480 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.480 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.479 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.479 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.479 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.478 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.477 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.477 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.476 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.475 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.475 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.475 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.474 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.474 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.474 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.473 | |
| 3ieu | GDP | GTPase Era | / | 0.473 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.473 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.473 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.472 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.472 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.472 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.472 | |
| 1e1c | DCA | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.471 | |
| 1njf | ADP | DNA polymerase III subunit tau | 2.7.7.7 | 0.471 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.471 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.471 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.471 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.470 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.469 | |
| 2rhq | GAX | Phenylalanine--tRNA ligase alpha subunit | / | 0.469 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.469 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.469 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.469 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.469 | |
| 5dp2 | NAP | CurF | / | 0.469 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.468 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.468 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.468 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.468 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.467 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.466 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.466 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.465 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.465 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.464 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.464 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.464 | |
| 2g9u | G27 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.464 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.464 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.463 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.463 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.463 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.463 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.463 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.462 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.462 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.462 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.461 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.461 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.461 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.460 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.460 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.460 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.460 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.460 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.460 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.460 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 5a8a | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.460 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.459 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.459 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.459 | |
| 2vhq | ATP | NTPase P4 | / | 0.459 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.459 | |
| 3ua8 | 08W | Glutamate receptor 2 | / | 0.459 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.459 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.459 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.459 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.459 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.459 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.459 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.459 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.458 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.458 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.458 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.458 | |
| 1sny | NAP | LD36273p | / | 0.458 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.458 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.458 | |
| 5eso | ISC | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.458 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.457 | |
| 2h2a | DND | Probable nicotinate-nucleotide adenylyltransferase | / | 0.457 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.457 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.457 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3fvl | BHK | Carboxypeptidase A1 | 3.4.17.1 | 0.457 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.457 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.457 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.457 | |
| 4wbn | GTP | Tubulin alpha-1B chain | / | 0.457 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.456 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.456 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.456 | |
| 5c3a | URM | Histo-blood group ABO system transferase | / | 0.456 | |
| 6req | 3CP | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.456 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.455 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.455 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.455 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.455 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.455 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.455 | |
| 2wb2 | FAD | RE11660p | / | 0.455 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.455 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.455 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.454 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1vso | AT1 | Glutamate receptor ionotropic, kainate 1 | / | 0.454 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.454 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.454 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.454 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4eo3 | FMN | Bacterioferritin comigratory protein/NADH dehydrogenase | / | 0.454 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.454 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.454 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.453 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.453 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.453 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.453 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.452 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.452 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.452 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.452 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.452 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.452 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.452 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 4zol | GTP | Tubulin alpha-1B chain | / | 0.452 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.452 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.451 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.451 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.451 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.451 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.451 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.451 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.451 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.451 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.451 | |
| 4wzh | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.451 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.451 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.450 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.450 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.450 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.450 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.450 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.450 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.450 | |
| 3pft | FMN | Flavin reductase | / | 0.450 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.450 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.450 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.449 | |
| 1wkh | PPE | [LysW]-aminoadipate semialdehyde transaminase | / | 0.449 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.449 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.449 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.449 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.449 | |
| 4die | C5P | Cytidylate kinase | / | 0.449 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.449 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.448 | |
| 1zk7 | FAD | Mercuric reductase | 1.16.1.1 | 0.448 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.448 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.448 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 3a37 | ADP | ATPase GET3 | / | 0.448 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1ndi | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.447 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.447 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.447 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.447 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.447 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.447 | |
| 4abk | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.447 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.447 | |
| 4i52 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.447 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.447 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.447 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.446 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.446 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.446 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.446 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.446 | |
| 2q0k | NAP | Thioredoxin reductase | 1.8.1.9 | 0.446 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.446 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.446 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.446 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.446 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.446 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.446 | |
| 3ska | 053 | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4irn | FAD | AnaB | / | 0.446 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.446 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.446 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.446 | |
| 1g8j | MGD | Arsenite oxidase subunit AioA | 1.20.9.1 | 0.445 | |
| 2yyu | C5P | Orotidine 5'-phosphate decarboxylase | / | 0.445 | |
| 3ge6 | FMN | Nitroreductase | / | 0.445 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.445 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.445 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.445 | |
| 4wxg | 2BO | Serine hydroxymethyltransferase | / | 0.445 | |
| 5c41 | ACP | Ribokinase | / | 0.445 | |
| 1jue | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.444 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.444 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.444 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.444 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.444 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.444 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.444 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.444 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.444 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.444 | |
| 3hf3 | FMN | Chromate reductase | / | 0.444 | |
| 3pju | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.444 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.444 | |
| 3wag | TYD | Glycosyltransferase | / | 0.444 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.444 | |
| 4ctk | SAM | Genome polyprotein | / | 0.444 | |
| 4y38 | 0A9 | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.444 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.443 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.443 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.443 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.443 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.443 | |
| 2zr9 | DTP | Protein RecA | / | 0.443 | |
| 3dk8 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.443 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.443 | |
| 4b0q | GMF | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4gid | 0GH | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.443 | |
| 4z38 | FMN | MlnA | / | 0.443 | |
| 5ahs | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 5kj6 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.442 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.442 | |
| 1kqd | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.442 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.442 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2hjr | APR | Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase | / | 0.442 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.442 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.442 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.442 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.442 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.442 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 3pbl | ETQ | D(3) dopamine receptor | / | 0.442 | |
| 1gp2 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.441 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.441 | |
| 1n75 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.441 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.441 | |
| 2j08 | IRF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.441 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.441 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.441 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.441 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.441 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.441 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.441 | |
| 4eqw | FAD | Coenzyme A disulfide reductase | / | 0.441 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.441 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.441 | |
| 5eyu | NAD | Betaine-aldehyde dehydrogenase | / | 0.441 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.440 | |
| 1w7k | ADP | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.440 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.440 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2yqz | SAM | Uncharacterized protein | / | 0.440 | |
| 3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.440 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.440 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.440 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.440 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.440 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.440 |