Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4q93 | STL | Tyrosine--tRNA ligase, cytoplasmic | 6.1.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4q93 | STL | Tyrosine--tRNA ligase, cytoplasmic | 6.1.1.1 | 1.000 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.509 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.491 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.489 | |
| 3zl8 | ADP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.488 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.487 | |
| 2cmo | M1L | Glutamate receptor 2 | / | 0.484 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.484 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.483 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.483 | |
| 4wxg | 2BO | Serine hydroxymethyltransferase | / | 0.482 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.481 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.480 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.480 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.479 | |
| 2ejz | SAH | Diphthine synthase | / | 0.478 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.477 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.477 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.476 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.475 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.474 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.474 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.474 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.472 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.471 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.470 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.470 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 2jla | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.469 | |
| 5jjs | SAH | Genome polyprotein | / | 0.469 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.467 | |
| 2e15 | SAH | Diphthine synthase | / | 0.467 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.467 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.466 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.466 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.466 | |
| 4fhb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.465 | |
| 1pwu | GM6 | Lethal factor | 3.4.24.83 | 0.465 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.465 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.465 | |
| 4yjd | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.465 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.464 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.464 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.464 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 1m8g | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.463 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.463 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.463 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.463 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.463 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.463 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.462 | |
| 2emu | SAH | Diphthine synthase | / | 0.462 | |
| 4yqf | GDP | Septin-9 | / | 0.462 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.461 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.461 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.461 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.461 | |
| 2owk | SAH | Diphthine synthase | / | 0.461 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.461 | |
| 3hl4 | CDC | Choline-phosphate cytidylyltransferase A | / | 0.461 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.461 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.461 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.461 | |
| 1f9a | ATP | Nicotinamide-nucleotide adenylyltransferase | / | 0.460 | |
| 2hut | SAH | Diphthine synthase | / | 0.460 | |
| 2pca | SAH | Diphthine synthase | / | 0.460 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.460 | |
| 1g28 | FMN | PHY3 | / | 0.459 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.459 | |
| 2huq | SAH | Diphthine synthase | / | 0.459 | |
| 2v1a | FMN | NPH1-1 | / | 0.459 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.459 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.459 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.459 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.459 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.459 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.459 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.458 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.458 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.458 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.458 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.458 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.458 | |
| 4xq6 | FMN | Dihydroorotate dehydrogenase (quinone) | / | 0.458 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.458 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1m8j | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.457 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.457 | |
| 2dxw | SAH | Diphthine synthase | / | 0.457 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.457 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.457 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.456 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.456 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.456 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.456 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.456 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.455 | |
| 2pch | SAH | Diphthine synthase | / | 0.455 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.455 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.455 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.455 | |
| 3thy | ADP | DNA mismatch repair protein Msh2 | / | 0.455 | |
| 4u7w | NDP | MxaA | / | 0.455 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.454 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.454 | |
| 2dek | SAH | Diphthine synthase | / | 0.454 | |
| 2fb3 | 5AD | GTP 3',8-cyclase | 4.1.99.18 | 0.454 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 3c1o | NAP | Eugenol synthase | / | 0.454 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.454 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.454 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.454 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.453 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 2c3c | NAP | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.453 | |
| 2eh4 | SAH | Diphthine synthase | / | 0.453 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.453 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.453 | |
| 2z6r | SAH | Diphthine synthase | / | 0.453 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.453 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.453 | |
| 4e9a | QAP | Peptide deformylase | / | 0.453 | |
| 5fa1 | C5P | Putative N-acetyl glucosaminyl transferase | / | 0.453 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.452 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.452 | |
| 2e17 | SAH | Diphthine synthase | / | 0.452 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.452 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.452 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.452 | |
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.452 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.452 | |
| 4ijr | NDP | D-arabinose dehydrogenase [NAD(P)+] heavy chain | 1.1.1.117 | 0.452 | |
| 1nen | DNT | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.451 | |
| 1nen | DNT | Succinate dehydrogenase cytochrome b556 subunit | / | 0.451 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.451 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.451 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.451 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.451 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.451 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.451 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.450 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.450 | |
| 2yoj | 8Y6 | Genome polyprotein | 2.7.7.48 | 0.450 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.450 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.450 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.449 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2emr | SAH | Diphthine synthase | / | 0.449 | |
| 2owg | SAH | Diphthine synthase | / | 0.449 | |
| 2p9d | SAH | Diphthine synthase | / | 0.449 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.449 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.449 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.449 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.449 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.449 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.449 | |
| 4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | / | 0.449 | |
| 4hdr | DMD | ArsB | / | 0.449 | |
| 4hsu | FAD | Lysine-specific histone demethylase 1B | 1 | 0.449 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.449 | |
| 4lxm | 1YU | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.449 | |
| 4zhi | ADP | Kinesin-like protein KIF11 | / | 0.449 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.448 | |
| 2e16 | SAH | Diphthine synthase | / | 0.448 | |
| 2huv | SAH | Diphthine synthase | / | 0.448 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.448 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.448 | |
| 3eku | CY9 | Actin-5C | / | 0.448 | |
| 3ely | SAH | Methyltransferase | / | 0.448 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.448 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.448 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.448 | |
| 1rct | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 1rz0 | FAD | Phenol 2-hydroxylase component B | / | 0.447 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.447 | |
| 2os1 | BB2 | Peptide deformylase | / | 0.447 | |
| 2pcm | SAH | Diphthine synthase | / | 0.447 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.447 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.447 | |
| 4de5 | 0JD | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 4i0j | 842 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.447 | |
| 4uoc | NCN | CinA-like protein | / | 0.447 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.446 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.446 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.446 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.446 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.446 | |
| 2e4n | SAH | Diphthine synthase | / | 0.446 | |
| 2owf | SAH | Diphthine synthase | / | 0.446 | |
| 2pck | SAH | Diphthine synthase | / | 0.446 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.446 | |
| 3eks | CY9 | Actin-5C | / | 0.446 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.446 | |
| 3kem | IPE | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.446 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.446 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 4qtn | NNR | Nicotinamide riboside transporter PnuC | / | 0.446 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.446 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.446 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 5e9e | ANP | Myosin heavy chain kinase A | 2.7.11.7 | 0.446 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1ej2 | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.445 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.445 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.445 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2dsi | SAH | Diphthine synthase | / | 0.445 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.445 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.445 | |
| 2p2x | SAH | Diphthine synthase | / | 0.445 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 4rel | KMP | Glycosyltransferase | / | 0.445 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.445 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.445 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.445 | |
| 1nas | ASE | Sepiapterin reductase | 1.1.1.153 | 0.444 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.444 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.444 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.444 | |
| 2eld | SAH | Diphthine synthase | / | 0.444 | |
| 2p6l | SAH | Diphthine synthase | / | 0.444 | |
| 3akl | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.444 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.444 | |
| 3eld | SFG | Methyltransferase | / | 0.444 | |
| 3g2h | KOT | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.444 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.444 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.444 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.444 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.443 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.443 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.443 | |
| 2axn | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | / | 0.443 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.443 | |
| 2trs | PLS | Tryptophan synthase beta chain | 4.2.1.20 | 0.443 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.443 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.443 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.443 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.443 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.443 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.443 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.442 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.442 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.442 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.442 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3co9 | 3MS | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.442 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4eue | NAI | Trans-2-enoyl-CoA reductase [NADH] | / | 0.442 | |
| 4f1y | CNI | Glutamate receptor 3 | / | 0.442 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.442 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 4xr9 | NAD | CalS8 | / | 0.442 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.442 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.441 | |
| 1b8o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.441 | |
| 1vce | SAH | Diphthine synthase | / | 0.441 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.441 | |
| 2eka | SAH | Diphthine synthase | / | 0.441 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.441 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.441 | |
| 2y3s | TIR | TamL | / | 0.441 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3i0a | DBH | Neutrophil gelatinase-associated lipocalin | / | 0.441 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.441 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.441 | |
| 4fri | DWA | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.440 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.440 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.440 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.440 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.440 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.440 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.440 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.440 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.440 | |
| 4yp5 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.440 |