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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4q02GDPGTPase KRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4q02GDPGTPase KRas/1.000
4epwGDPGTPase KRas/0.713
4lv6GDPGTPase KRas/0.658
4l8gGDPGTPase KRas/0.649
3k9lGNPGTPase HRas/0.648
4ldjGDPGTPase KRas/0.645
4epxGDPGTPase KRas/0.638
3kkqGDPRas-related protein M-Ras/0.630
4tq9GDPGTPase KRas/0.627
4l9sGDPGTPase HRas/0.625
4obeGDPGTPase KRas/0.625
4q03GDPGTPase KRas/0.623
4lpkGDPGTPase KRas/0.616
4ql3GDPGTPase KRas/0.615
4wa7GDPGTPase KRas/0.610
4lrwGDPGTPase KRas/0.609
4xvqGNPGTPase HRas/0.602
3tgpGNPGTPase HRas/0.600
4hdqGNPRas-related protein Rap-1b/0.598
2rggGNPGTPase HRas/0.597
1lfdGNPGTPase HRas/0.586
2ce2GDPGTPase HRas/0.586
4xvrGNPGTPase HRas/0.579
3i3sGNPGTPase HRas/0.571
1x1rGDPRas-related protein M-Ras/0.567
3x1wGDPRas-related protein Rap-1b/0.567
3qbtGNPRas-related protein Rab-8A/0.566
4nyjGNPGTPase HRas/0.566
3tsoGNPRas-related protein Rab-25/0.563
4o2rGDPGTP-binding protein Rheb/0.559
2c5lGTPGTPase HRas/0.557
2fg5GNPRas-related protein Rab-31/0.557
2rgeGNPGTPase HRas/0.556
3kkoGNPRas-related protein M-Ras/0.555
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.553
3rs4GNPGTPase HRas/0.552
4dsuGDPGTPase KRas/0.551
1n6lGTPRas-related protein Rab-5A/0.550
3ddcGNPGTPase HRas/0.549
3rs5GNPGTPase HRas/0.547
3lbhGNPGTPase HRas/0.546
4dlvGNPGTPase HRas/0.544
1uadGNPRas-related protein Ral-A/0.543
5difGNPGTP-binding nuclear protein Ran/0.543
2mscGDPMHC class I alpha chain/0.541
2fe4GDPRas-related protein Rab-6B/0.540
3l8yGNPGTPase HRas/0.540
3oivGNPGTPase HRas/0.540
3v4fGNPGTPase HRas/0.540
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.538
2bmeGNPRas-related protein Rab-4A/0.537
5b2zGNPGTPase HRas/0.534
4dlxGNPGTPase HRas/0.533
4dlzGNPGTPase HRas/0.532
4nyiGNPGTPase HRas/0.532
2rgcGNPGTPase HRas/0.530
3oiuGNPGTPase HRas/0.530
4dsnGCPGTPase KRas/0.530
4dxaGSPRas-related protein Rap-1b/0.530
4uj3GNPRas-related protein Rab-11A/0.529
1zc4GNPRas-related protein Ral-A/0.526
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.526
3rslGNPGTPase HRas/0.526
3pitGNPRas-related protein M-Ras/0.525
3x1zGNPRas-related protein Rap-1b/0.525
3cphGDPRas-related protein SEC4/0.522
3oiwGNPGTPase HRas/0.522
3rs7GNPGTPase HRas/0.522
4dlsGNPGTPase HRas/0.522
1yu9GNPRas-related protein Rab-4A/0.520
3lbiGNPGTPase HRas/0.519
2cl6CAGGTPase HRas/0.518
3lbnGNPGTPase HRas/0.518
3k8yGNPGTPase HRas/0.516
4dlwGNPGTPase HRas/0.516
3rs0GNPGTPase HRas/0.515
5dhaGNPGTP-binding nuclear protein Ran/0.514
2rgbGNPGTPase HRas/0.513
4dltGNPGTPase HRas/0.512
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.512
3kudGDPGTPase HRas/0.511
4lhwGNPRas-related protein Rab-8A/0.511
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.510
4uj5GNPRas-related protein Rab-11A/0.510
1g17GNPRas-related protein SEC4/0.509
4l9wGNPGTPase HRas/0.509
3a58GNPGTP-binding protein RHO1/0.508
1zbdGTPRas-related protein Rab-3A/0.505
2l0xGDPGTP-binding protein Rheb/0.504
1d5cGDPGTPase (Rab6)/0.502
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.502
4g0nGNPGTPase HRas/0.502
1ky2GNPGTP-binding protein YPT7/0.497
4hdoGNPRas-related protein Rap-1b/0.497
1a4rGNHCell division control protein 42 homolog/0.496
1kmqGNPTransforming protein RhoA/0.494
3kucGDPRas-related protein Rap-1A/0.494
1oixGDPRas-related protein Rab-11A/0.493
1zc3GNPRas-related protein Ral-A/0.493
1npdNADQuinate/shikimate dehydrogenase/0.492
1xtsGTPGTP-binding protein Rheb/0.492
1cxzGSPTransforming protein RhoA/0.490
1zd9GDPADP-ribosylation factor-like protein 8A/0.490
2c29NAPDihydroflavonol 4-reductase/0.490
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.490
3vhxGTPADP-ribosylation factor 6/0.490
4qxaGTPRas-related protein Rab-9A/0.490
1e96GTPRas-related C3 botulinum toxin substrate 1/0.487
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.487
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.486
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.486
1m78NDPDihydrofolate reductase1.5.1.30.485
3cobADPKinesin heavy chain-like protein/0.484
3t4eNADQuinate/shikimate dehydrogenase/0.484
4u3jGTPTubulin beta chain/0.484
2msdGNPMHC class I alpha chain/0.483
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.483
1xtrGNPGTP-binding protein Rheb/0.482
5jljGNPGTP-binding nuclear protein Ran/0.482
1kquBR4Phospholipase A2, membrane associated/0.481
1s3uTQDDihydrofolate reductase1.5.1.30.481
4j49NAIUncharacterized protein/0.481
4rkfGNPRas-related protein Rab-3/0.480
1yzqGNPRas-related protein Rab-6A/0.479
4dc0NDPPutative ketoacyl reductase1.3.10.479
3ea5GDPGTP-binding nuclear protein Ran/0.478
1rx8NAPDihydrofolate reductase1.5.1.30.477
1z2aGDPRas-related protein Rab-23/0.477
2q3fGNPRas-related GTP-binding protein D/0.477
1a2bGSPTransforming protein RhoA/0.476
1g16GDPRas-related protein SEC4/0.476
1mvtDTMDihydrofolate reductase1.5.1.30.476
1n83CLRNuclear receptor ROR-alpha/0.476
4r1lADPPhenylacetate-coenzyme A ligase/0.476
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.474
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.474
4jauADPSensor histidine kinase/0.474
4x5iFOLDihydrofolate reductase1.5.1.30.474
4l4cCAMCamphor 5-monooxygenase1.14.15.10.473
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.472
1vyrFMNPentaerythritol tetranitrate reductase/0.472
1z7yAA5Cysteine synthase 12.5.1.470.472
2bkuGTPGTP-binding nuclear protein Ran/0.472
2oo7AP5Adenylate kinase/0.472
4k6fNAPPutative Acetoacetyl-CoA reductase/0.472
1z0dGDPRas-related protein Rab-5C/0.471
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.471
4dsoGSPGTPase KRas/0.471
4ycpFMNtRNA-dihydrouridine(16) synthase/0.471
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.469
2cy2ACOProbable acetyltransferase/0.468
3bbpGTPRas-related protein Rab-6A/0.468
3fhxPLPPyridoxal kinase2.7.1.350.468
1pq944BOxysterols receptor LXR-beta/0.467
1vg8GNPRas-related protein Rab-7a/0.467
2gcpGSPRho-related GTP-binding protein RhoC/0.467
3th5GNPRas-related C3 botulinum toxin substrate 1/0.467
4bcoT6QCyclin-dependent kinase 22.7.11.220.467
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.466
1o76CAMCamphor 5-monooxygenase1.14.15.10.466
1ow3GDPTransforming protein RhoA/0.466
1t91GTPRas-related protein Rab-7a/0.466
2oegUPGUDP-glucose pyrophosphorylase/0.466
3oesGNPGTPase RhebL1/0.466
4an4DUDPutative glycosyl transferase/0.466
5iqiGNPBifunctional AAC/APH2.3.10.466
2z4sADPChromosomal replication initiator protein DnaA/0.465
3p67FMNPentaerythritol tetranitrate reductase/0.465
4b722FBBeta-secretase 13.4.23.460.465
4dbzNDPPutative ketoacyl reductase1.3.10.465
4kvgGTPRas-related protein Rap-1A/0.465
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.465
4u7wNDPMxaA/0.465
1mvsDTMDihydrofolate reductase1.5.1.30.464
2dxdANPNucleoside diphosphate kinase2.7.4.60.464
2mseGNPMHC class I alpha chain/0.464
3a6pGTPGTP-binding nuclear protein Ran/0.464
3rabGNPRas-related protein Rab-3A/0.464
4bahMELProthrombin3.4.21.50.464
4f31KAIGlutamate receptor 3/0.464
1o9bNAIQuinate/shikimate dehydrogenase/0.463
1pd9CO4Dihydrofolate reductase1.5.1.30.463
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
4o25GTPGTP-binding protein Rheb/0.463
4ztvTA7Anthranilate phosphoribosyltransferase/0.463
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.462
2pg0FADAcyl-CoA dehydrogenase/0.462
3l0lHC3Nuclear receptor ROR-gamma/0.462
4cidANPEH domain-containing protein 2/0.462
4djx0KQBeta-secretase 13.4.23.460.462
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
1dz8CAMCamphor 5-monooxygenase1.14.15.10.461
1hb1OCVIsopenicillin N synthase1.21.3.10.461
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.461
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.461
4p9dTMPDeoxycytidylate deaminase/0.461
1gtrATPGlutamine--tRNA ligase6.1.1.180.460
1nhkCMPNucleoside diphosphate kinase2.7.4.60.460
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.460
1wxjIPLTryptophan synthase alpha chain/0.460
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.460
3p74FMNPentaerythritol tetranitrate reductase/0.460
4ehv0SJMitogen-activated protein kinase 14/0.460
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.460
1drhNAPDihydrofolate reductase1.5.1.30.459
2nnqT4BFatty acid-binding protein, adipocyte/0.459
4iarERM5-hydroxytryptamine receptor 1B/0.459
5iqaGNPBifunctional AAC/APH2.3.10.459
1kceCB3Thymidylate synthase/0.458
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.458
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.458
2v7qADPATP synthase subunit beta, mitochondrial3.6.3.140.458
2wo7ASVIsopenicillin N synthase1.21.3.10.458
3gwdNAPCyclohexanone monooxygenase/0.458
3t3q9PLCytochrome P450 2A61.14.130.458
4fhd0TTSpore photoproduct lyase/0.458
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.458
4m8e29VRetinoic acid receptor RXR-alpha/0.458
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.458
1f9aATPNicotinamide-nucleotide adenylyltransferase/0.457
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.457
1towCRZFatty acid-binding protein, adipocyte/0.457
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.457
2h15B19Carbonic anhydrase 24.2.1.10.457
3cyz9ODPheromone-binding protein ASP1/0.457
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3s3vTOPDihydrofolate reductase1.5.1.30.457
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.457
4nbwNADShort-chain dehydrogenase/reductase SDR/0.457
4yakCOAAcyl-CoA synthetase (NDP forming)/0.457
1drfFOLDihydrofolate reductase1.5.1.30.456
1m7bGTPRho-related GTP-binding protein RhoE/0.456
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.456
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.456
2x06NADL-sulfolactate dehydrogenase/0.456
2yg4FADPutrescine oxidase/0.456
3ft5MO8Heat shock protein HSP 90-alpha/0.456
4g01GDPRas-related protein RABF2b/0.456
4mitGTPRho-related protein racC/0.456
4obuPLPPyridoxal-dependent decarboxylase domain protein/0.456
1e0jANPDNA primase/helicase2.7.70.455
3csoXNIGenome polyprotein2.7.7.480.455
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3ijdC2FMethylenetetrahydrofolate reductase/0.455
3x2fNAIAdenosylhomocysteinase/0.455
4mv1ADPBiotin carboxylase6.3.4.140.455
4pnmNU1Tankyrase-22.4.2.300.455
5cb3APRO-acetyl-ADP-ribose deacetylase/0.455
1bcpATPPertussis toxin subunit 4/0.454
1bcpATPPertussis toxin subunit 5/0.454
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.454
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.454
2c2aADPSensor histidine kinase/0.454
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.454
2oaxSNLMineralocorticoid receptor/0.454
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4lzwTHMUridine phosphorylase/0.454
4udqFAD5-(hydroxymethyl)furfural oxidase/0.454
5dhgDGVNociceptin receptor/0.454
1s3vTQDDihydrofolate reductase1.5.1.30.453
1zrb062Prothrombin3.4.21.50.453
2p1u4TNRetinoic acid receptor RXR-alpha/0.453
3ictADPCoenzyme A disulfide reductase/0.453
4jdcNADProbable pyrroline-5-carboxylate dehydrogenase RocA/0.453
4o4fATPKinase/0.453
1cbqRE9Cellular retinoic acid-binding protein 2/0.452
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.452
1yhnGTPRas-related protein Rab-7a/0.452
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.452
2xvv9DNSerum albumin/0.452
3dc3AZMCarbonic anhydrase 24.2.1.10.452
3ekuCY9Actin-5C/0.452
3eq02TSProthrombin3.4.21.50.452
3fhiANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3tozNADShikimate dehydrogenase (NADP(+))/0.452
3up0D7SaceDAF-12/0.452
4g2gTDHMycocyclosin synthase1.14.21.90.452
5di3GNPADP-ribosylation factor-like protein 3/0.452
1dr3TAPDihydrofolate reductase1.5.1.30.451
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.451
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.451
1r2jFADFkbI/0.451
1rszDIHPurine nucleoside phosphorylase2.4.2.10.451
1s0xC3SNuclear receptor ROR-alpha/0.451
1v8kANPKinesin-like protein KIF2C/0.451
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.451
2a1mCAMCamphor 5-monooxygenase1.14.15.10.451
2gnaGDUUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.451
2xtnGTPGTPase IMAP family member 2/0.451
3dcsMZMCarbonic anhydrase 24.2.1.10.451
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3jwm5WBDihydrofolate reductase/0.451
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.451
3p62FMNPentaerythritol tetranitrate reductase/0.451
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4eb4UMPThymidylate synthase2.1.1.450.451
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.451
4q71FADBifunctional protein PutA/0.451
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.451
4xymCOAAcyl-CoA synthetase (NDP forming)/0.451
5iqbGNPBifunctional AAC/APH2.3.10.451
1cqp803Integrin alpha-L/0.450
1n77ATPGlutamate--tRNA ligase6.1.1.170.450
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2gjlFMNNitronate monooxygenase1.13.12.160.450
2vbdV10Isopenicillin N synthase1.21.3.10.450
3pcrGTPADP-ribosylation factor 6/0.450
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.450
4ixd1HVIntegrin alpha-L/0.450
4js0GNPCell division control protein 42 homolog/0.450
5hi6MTXDihydrofolate reductase/0.450
1kvkATPMevalonate kinase2.7.1.360.449
1pqc444Oxysterols receptor LXR-beta/0.449
1uy8PU5Heat shock protein HSP 90-alpha/0.449
1xe65FPPlasmepsin-23.4.23.390.449
2a9y26AAdenosine kinase2.7.1.200.449
2zbaZBATrichothecene 3-O-acetyltransferase/0.449
3mohGDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.449
3pcnDHYProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.449
3pcnDHYProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.449
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.449
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.449
4xg1LLPDiaminopimelate decarboxylase/0.449
4xrbNDPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.449
4y8wSTRSteroid 21-hydroxylase/0.449
5iotUMPFlavin-dependent thymidylate synthase2.1.1.1480.449
1bk0ACVIsopenicillin N synthase1.21.3.10.448
1ia4TQ6Dihydrofolate reductase1.5.1.30.448
1ibrGNPGTP-binding nuclear protein Ran/0.448
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.448
1njaDCMThymidylate synthase/0.448
1p8dCO1Oxysterols receptor LXR-beta/0.448
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.448
1vf2GTXGlutathione S-transferase 32.5.1.180.448
1xowR18Androgen receptor/0.448
2g0lFLNNeocarzinostatin/0.448
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.448
2pauD5M5'-deoxynucleotidase YfbR/0.448
2yg3FADPutrescine oxidase/0.448
2z3uCRRCytochrome P450/0.448
2zfp19UProthrombin3.4.21.50.448
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.448
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.448
4b4vL34Bifunctional protein FolD/0.448
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.448
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.448
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.447
2az3CDPNucleoside diphosphate kinase/0.447
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.447
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.447
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4bvaT3Ketimine reductase mu-crystallin1.5.1.250.447
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4imgNGFN-acetylneuraminate lyase/0.447
5epvACPBlue-light-activated histidine kinase2.7.13.30.447
1kw6BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.446
1touB1VFatty acid-binding protein, adipocyte/0.446
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1zgv501Prothrombin3.4.21.50.446
2ovhAS0Progesterone receptor/0.446
3d7zGK5Mitogen-activated protein kinase 14/0.446
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.446
3gb4D3MDdmC/0.446
3lqfNADGalactitol dehydrogenase/0.446
3w0aDS5Vitamin D3 receptor/0.446
3wv9FEGHmd co-occurring protein HcgE/0.446
4d0lGSPRas-related protein Rab-11A/0.446
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4ho9UTPGlucose-1-phosphate thymidylyltransferase/0.446
5hpyGDPTransforming protein RhoA/0.446
1ia3TQ5Dihydrofolate reductase1.5.1.30.445
1ii6ADPKinesin-like protein KIF11/0.445
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.445
1mabADPATP synthase subunit beta, mitochondrial3.6.3.140.445
1mu6CDAProthrombin3.4.21.50.445
1rd4L08Integrin alpha-L/0.445
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.445
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.445
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.445
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.445
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.445
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
2r9eSDXCitrate synthase2.3.3.160.445
3fowIMHPurine nucleoside phosphorylase/0.445
3qw4U5POrotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative/0.445
3rgaILDEpoxide hydrolase LasB5.5.10.445
3umsGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.445
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.445
4b4w9L9Bifunctional protein FolD/0.445
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.445
4i0j842Beta-secretase 13.4.23.460.445
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.445
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.445
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.445
5iqdGNPBifunctional AAC/APH2.3.10.445
5iqgGDPBifunctional AAC/APH2.3.10.445
1l8qADPChromosomal replication initiator protein DnaA/0.444
1mznBM6Retinoic acid receptor RXR-alpha/0.444
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.444
2ffqGSPRas-related protein Rab-6B/0.444
2ft9CHDFatty acid-binding protein 2, liver/0.444
2g78REACellular retinoic acid-binding protein 2/0.444
2h2jSFGRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.444
2p1v5TNRetinoic acid receptor RXR-alpha/0.444
3f03FMNPentaerythritol tetranitrate reductase/0.444
3h1vTK1Glucokinase2.7.1.20.444
3h3r14HCollagen type IV alpha-3-binding protein/0.444
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.444
4cf8V7HIntegrase/0.444
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.444
4ehyADPTetraacyldisaccharide 4'-kinase/0.444
4tjy3GNTankyrase-22.4.2.300.444
4x5jFOLDihydrofolate reductase1.5.1.30.444
1dr3HBIDihydrofolate reductase1.5.1.30.443
1hb3SCVIsopenicillin N synthase1.21.3.10.443
1ia1NDPDihydrofolate reductase1.5.1.30.443
1jtuLYBThymidylate synthase/0.443
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1lcwSHMStreptavidin/0.443
1mewXMPInosine-5'-monophosphate dehydrogenase/0.443
1q5dEPBEpothilone C/D epoxidase1.140.443
2byi2DDHeat shock protein HSP 90-alpha/0.443
2dhfDZFDihydrofolate reductase1.5.1.30.443
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.443
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.443
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.443
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.443
3kz1GSPTransforming protein RhoA/0.443
3n1t5GPPurine nucleoside phosphoramidase/0.443
3s1dZIRCytokinin dehydrogenase 11.5.99.120.443
3t7vSAM3-methylornithine synthase/0.443
3tk3CPZCytochrome P450 2B41.14.14.10.443
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.443
3w8dNAD3-hydroxybutyrate dehydrogenase/0.443
3wrmCAMCamphor 5-monooxygenase1.14.15.10.443
3zv64HBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.443
4cf7ADPAdenylate kinase/0.443
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.443
4qbiAP5Adenylate kinase/0.443
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.443
4ure1PSCyclohexanol dehydrogenase/0.443
4ypuSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.443
1lwxAZDNucleoside diphosphate kinase, cytosolic2.7.4.60.442
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1rx8FOLDihydrofolate reductase1.5.1.30.442
2dw4FADLysine-specific histone demethylase 1A10.442
2ji9ADPOxalyl-CoA decarboxylase4.1.1.80.442
2pksG44Prothrombin3.4.21.50.442
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.442
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.442
3ac2KSETyrosine-protein kinase Lck2.7.10.20.442
3cz09ODPheromone-binding protein ASP1/0.442
3fwgCAMCamphor 5-monooxygenase1.14.15.10.442
3l5eBDWBeta-secretase 13.4.23.460.442
3qm4PN0Cytochrome P450 2D6/0.442
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3wrjCAMCamphor 5-monooxygenase1.14.15.10.442
3wrlCAMCamphor 5-monooxygenase1.14.15.10.442
4a2aATPCell division protein FtsA/0.442
4h1e10JBeta-secretase 13.4.23.460.442
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.442
4j491J1Uncharacterized protein/0.442
4tkg09LTankyrase-22.4.2.300.442
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
5iu86DZAdenosine receptor A2a/0.442
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.441
1db48INPhospholipase A2, membrane associated/0.441
1dr5NAPDihydrofolate reductase1.5.1.30.441
1dyiFOLDihydrofolate reductase1.5.1.30.441
1dyjDDFDihydrofolate reductase1.5.1.30.441
1jscTPPAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.441
1mueCDDProthrombin3.4.21.50.441
1o2g696Prothrombin3.4.21.50.441
1qiqACCIsopenicillin N synthase1.21.3.10.441
1rx1NAPDihydrofolate reductase1.5.1.30.441
1rzuADPGlycogen synthase 12.4.1.210.441
1zgi382Prothrombin3.4.21.50.441
2e0nSAHPrecorrin-2 C20-methyltransferase/0.441
2f3rG5PGuanylate kinase2.7.4.80.441
2g8dUMPThymidylate synthase/0.441
2hu2NADC-terminal binding protein 1/0.441
2puiADPMethylthioribose kinase2.7.1.1000.441
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.441
3aw9GDUNAD-dependent epimerase/dehydratase/0.441
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.441
3w8fNAD3-hydroxybutyrate dehydrogenase/0.441
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.441
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.441
4at0FADPossible succinate dehydrogenase/0.441
4bf9FMNtRNA-dihydrouridine(16) synthase/0.441
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4eji0QACytochrome P450 2A131.14.14.10.441
4fvrATPTyrosine-protein kinase JAK2/0.441
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4pkwGM6Lethal factor3.4.24.830.441
4rww2BALmo2692 protein/0.441
4x5hFOLDihydrofolate reductase1.5.1.30.441
5ch7MD1DMSO reductase family type II enzyme, molybdopterin subunit/0.441
1dr2TAPDihydrofolate reductase1.5.1.30.440
1eiiRTLRetinol-binding protein 2/0.440
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
1nbiSAMGlycine N-methyltransferase2.1.1.200.440
1u1f183Uridine phosphorylase2.4.2.30.440
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.440
2j0vGDPRac-like GTP-binding protein ARAC7/0.440
2vnhFADNADPH:ferredoxin reductase/0.440
3gdsVAL_TYR_TYR_PHESerine endoprotease DegS3.4.21.1070.440
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3qlwN22Dihydrofolate reductase1.5.1.30.440
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.440
4biwANPSensor histidine kinase CpxA/0.440
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4eyb0WOMetallo-beta-lactamase type 2/0.440
4f3gKAIGlutamate receptor 3/0.440
4g20484Vitamin D3 receptor A/0.440
4g2i0VQVitamin D3 receptor/0.440
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.440
4i13FOLDihydrofolate reductase1.5.1.30.440
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.440
4kne1CYDihydrofolate reductase1.5.1.30.440
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.440
4nmbFADBifunctional protein PutA/0.440
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.440