sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4pnm	NU1	Tankyrase-2	2.4.2.30

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4pnm	NU1	Tankyrase-2	2.4.2.30	1.000
4bj9	UHB	Tankyrase-2	2.4.2.30	0.580
4tjy	3GN	Tankyrase-2	2.4.2.30	0.565
4k4e	K4E	Tankyrase-1	2.4.2.30	0.527
4mt9	2D6	Tankyrase-1	2.4.2.30	0.522
4li6	1XO	Tankyrase-1	2.4.2.30	0.520
4li8	1XQ	Tankyrase-1	2.4.2.30	0.507
4tkg	09L	Tankyrase-2	2.4.2.30	0.507
4hyf	1AK	Tankyrase-2	2.4.2.30	0.496
4li7	1XP	Tankyrase-1	2.4.2.30	0.481
4bjb	P34	Tankyrase-2	2.4.2.30	0.476
4i9i	1DY	Tankyrase-1	2.4.2.30	0.476
4pnr	G18	Tankyrase-2	2.4.2.30	0.476
3u9y	09L	Tankyrase-2	2.4.2.30	0.468
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.452
4msk	2C8	Tankyrase-1	2.4.2.30	0.447