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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pl8ATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4pl8ATPActin, alpha skeletal muscle/1.000
3m6gATPActin, alpha skeletal muscle/0.611
1lotATPActin, alpha skeletal muscle/0.593
2q36ATPActin, alpha skeletal muscle/0.584
1c0fATPMajor actin/0.583
4pkhADPActin, alpha skeletal muscle/0.577
2v51ATPActin, alpha skeletal muscle/0.564
4k42ADPActin, alpha skeletal muscle/0.564
3mn6ATPActin-5C/0.562
1rgiATPActin, alpha skeletal muscle/0.560
3u9dATPActin, alpha skeletal muscle/0.556
4jhdANPActin-5C/0.555
4pkgATPActin, alpha skeletal muscle/0.554
3mn9ATPActin-5C/0.553
1h1vATPActin, alpha skeletal muscle/0.552
1ijjATPActin, alpha skeletal muscle/0.552
3ffkATPActin, alpha skeletal muscle/0.549
5ce3ATPActin/0.547
1nm1ATPMajor actin/0.543
3tu5ATPActin, alpha skeletal muscle/0.540
1kxpATPActin, alpha skeletal muscle/0.539
3m1fATPActin, alpha skeletal muscle/0.538
1qz5ATPActin, alpha skeletal muscle/0.535
1s22ATPActin, alpha skeletal muscle/0.526
3a5mATPMajor actin/0.525
3chwATPMajor actin/0.525
1t44ATPActin, alpha skeletal muscle/0.524
1nmdATPMajor actin/0.522
2q97ATPActin, alpha skeletal muscle/0.520
4ci6ATPActin/0.517
4m63ATPActin-5C/0.512
4rwtANPActin-5C/0.503
3u4lATPActin, cytoplasmic 1/0.489
1mduATPActin, alpha skeletal muscle/0.487
4k41ATPActin, alpha skeletal muscle/0.485
1nlvATPMajor actin/0.479
1wuaATPActin, alpha skeletal muscle/0.478
4pkiATPActin, alpha skeletal muscle/0.472
4cbxATPActin-2/0.466
2a41ATPActin, alpha skeletal muscle/0.448