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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pkgATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4pkgATPActin, alpha skeletal muscle/1.000
4k42ADPActin, alpha skeletal muscle/0.573
1lotATPActin, alpha skeletal muscle/0.558
3ffkATPActin, alpha skeletal muscle/0.557
3tu5ATPActin, alpha skeletal muscle/0.556
1h1vATPActin, alpha skeletal muscle/0.553
4pkhADPActin, alpha skeletal muscle/0.553
3m6gATPActin, alpha skeletal muscle/0.552
1c0fATPMajor actin/0.551
4pl8ATPActin, alpha skeletal muscle/0.530
1rgiATPActin, alpha skeletal muscle/0.529
3mn9ATPActin-5C/0.526
1nmdATPMajor actin/0.524
2q36ATPActin, alpha skeletal muscle/0.524
3mn6ATPActin-5C/0.519
5ce3ATPActin/0.516
4m63ATPActin-5C/0.512
2v51ATPActin, alpha skeletal muscle/0.506
1qz5ATPActin, alpha skeletal muscle/0.503
1s22ATPActin, alpha skeletal muscle/0.503
4ci6ATPActin/0.503
1ijjATPActin, alpha skeletal muscle/0.499
1mduATPActin, alpha skeletal muscle/0.497
3u4lATPActin, cytoplasmic 1/0.497
1kxpATPActin, alpha skeletal muscle/0.495
3u9dATPActin, alpha skeletal muscle/0.493
4pkiATPActin, alpha skeletal muscle/0.492
1t44ATPActin, alpha skeletal muscle/0.491
4jhdANPActin-5C/0.489
1nm1ATPMajor actin/0.479
4cbxATPActin-2/0.473
4rwtANPActin-5C/0.473
3a5mATPMajor actin/0.469
3m1fATPActin, alpha skeletal muscle/0.468
3chwATPMajor actin/0.465
2q97ATPActin, alpha skeletal muscle/0.442
1nlvATPMajor actin/0.441