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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4phlPILPhosphodiesterase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4phlPILPhosphodiesterase/1.000
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.514
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.495
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.490
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.486
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.484
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445