sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4obe | GDP | GTPase KRas |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4obe | GDP | GTPase KRas | / | 1.000 | |
| 4tq9 | GDP | GTPase KRas | / | 0.665 | |
| 4epw | GDP | GTPase KRas | / | 0.647 | |
| 4q02 | GDP | GTPase KRas | / | 0.637 | |
| 3kkq | GDP | Ras-related protein M-Ras | / | 0.630 | |
| 4epx | GDP | GTPase KRas | / | 0.622 | |
| 4l9s | GDP | GTPase HRas | / | 0.622 | |
| 4ql3 | GDP | GTPase KRas | / | 0.619 | |
| 4q03 | GDP | GTPase KRas | / | 0.616 | |
| 4ldj | GDP | GTPase KRas | / | 0.611 | |
| 4hdq | GNP | Ras-related protein Rap-1b | / | 0.610 | |
| 4l8g | GDP | GTPase KRas | / | 0.610 | |
| 4lpk | GDP | GTPase KRas | / | 0.604 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.596 | |
| 4lrw | GDP | GTPase KRas | / | 0.594 | |
| 4lv6 | GDP | GTPase KRas | / | 0.594 | |
| 3tgp | GNP | GTPase HRas | / | 0.591 | |
| 4xvq | GNP | GTPase HRas | / | 0.591 | |
| 2rgg | GNP | GTPase HRas | / | 0.580 | |
| 3ddc | GNP | GTPase HRas | / | 0.580 | |
| 2bme | GNP | Ras-related protein Rab-4A | / | 0.579 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.577 | |
| 1x1r | GDP | Ras-related protein M-Ras | / | 0.576 | |
| 4wa7 | GDP | GTPase KRas | / | 0.576 | |
| 4xvr | GNP | GTPase HRas | / | 0.576 | |
| 3cph | GDP | Ras-related protein SEC4 | / | 0.574 | |
| 2ce2 | GDP | GTPase HRas | / | 0.573 | |
| 3kko | GNP | Ras-related protein M-Ras | / | 0.570 | |
| 5b2z | GNP | GTPase HRas | / | 0.570 | |
| 3rs4 | GNP | GTPase HRas | / | 0.568 | |
| 2rge | GNP | GTPase HRas | / | 0.567 | |
| 2fg5 | GNP | Ras-related protein Rab-31 | / | 0.566 | |
| 3x1w | GDP | Ras-related protein Rap-1b | / | 0.566 | |
| 1mh1 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.563 | |
| 2rgb | GNP | GTPase HRas | / | 0.563 | |
| 3rsl | GNP | GTPase HRas | / | 0.563 | |
| 4dls | GNP | GTPase HRas | / | 0.563 | |
| 3lbh | GNP | GTPase HRas | / | 0.561 | |
| 3l8y | GNP | GTPase HRas | / | 0.560 | |
| 3lbn | GNP | GTPase HRas | / | 0.560 | |
| 3tso | GNP | Ras-related protein Rab-25 | / | 0.560 | |
| 3i3s | GNP | GTPase HRas | / | 0.558 | |
| 3k9l | GNP | GTPase HRas | / | 0.558 | |
| 4g0n | GNP | GTPase HRas | / | 0.557 | |
| 1n6l | GTP | Ras-related protein Rab-5A | / | 0.555 | |
| 3lbi | GNP | GTPase HRas | / | 0.555 | |
| 3rs0 | GNP | GTPase HRas | / | 0.554 | |
| 3x1z | GNP | Ras-related protein Rap-1b | / | 0.553 | |
| 4nyi | GNP | GTPase HRas | / | 0.551 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.550 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.549 | |
| 3kud | GDP | GTPase HRas | / | 0.548 | |
| 2rgc | GNP | GTPase HRas | / | 0.547 | |
| 4dlv | GNP | GTPase HRas | / | 0.547 | |
| 4dsn | GCP | GTPase KRas | / | 0.547 | |
| 1uad | GNP | Ras-related protein Ral-A | / | 0.546 | |
| 1lfd | GNP | GTPase HRas | / | 0.545 | |
| 3k8y | GNP | GTPase HRas | / | 0.544 | |
| 3v4f | GNP | GTPase HRas | / | 0.544 | |
| 3oiv | GNP | GTPase HRas | / | 0.543 | |
| 4dlz | GNP | GTPase HRas | / | 0.543 | |
| 2c5l | GTP | GTPase HRas | / | 0.542 | |
| 2msc | GDP | MHC class I alpha chain | / | 0.542 | |
| 3rs5 | GNP | GTPase HRas | / | 0.542 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.538 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.538 | |
| 4nyj | GNP | GTPase HRas | / | 0.537 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.536 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.535 | |
| 1yu9 | GNP | Ras-related protein Rab-4A | / | 0.533 | |
| 3rs7 | GNP | GTPase HRas | / | 0.533 | |
| 2bku | GTP | GTP-binding nuclear protein Ran | / | 0.532 | |
| 3oiw | GNP | GTPase HRas | / | 0.532 | |
| 4dlt | GNP | GTPase HRas | / | 0.532 | |
| 4dlx | GNP | GTPase HRas | / | 0.532 | |
| 3oiu | GNP | GTPase HRas | / | 0.531 | |
| 4hdo | GNP | Ras-related protein Rap-1b | / | 0.531 | |
| 2p2l | GDP | Ras-related C3 botulinum toxin substrate 1 | / | 0.526 | |
| 4dlw | GNP | GTPase HRas | / | 0.526 | |
| 4l9w | GNP | GTPase HRas | / | 0.525 | |
| 4lhw | GNP | Ras-related protein Rab-8A | / | 0.524 | |
| 4dso | GSP | GTPase KRas | / | 0.523 | |
| 4rkf | GNP | Ras-related protein Rab-3 | / | 0.523 | |
| 1g17 | GNP | Ras-related protein SEC4 | / | 0.522 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.522 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.522 | |
| 1d5c | GDP | GTPase (Rab6) | / | 0.519 | |
| 1g16 | GDP | Ras-related protein SEC4 | / | 0.519 | |
| 5jlj | GNP | GTP-binding nuclear protein Ran | / | 0.519 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.518 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.518 | |
| 4dsu | GDP | GTPase KRas | / | 0.518 | |
| 1e96 | GTP | Ras-related C3 botulinum toxin substrate 1 | / | 0.517 | |
| 3ea5 | GDP | GTP-binding nuclear protein Ran | / | 0.517 | |
| 2cl6 | CAG | GTPase HRas | / | 0.515 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.510 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.510 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.509 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.508 | |
| 4uj3 | GNP | Ras-related protein Rab-11A | / | 0.508 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.506 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.505 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.505 | |
| 1t91 | GTP | Ras-related protein Rab-7a | / | 0.504 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.503 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.503 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.501 | |
| 3sbe | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.501 | |
| 4o25 | GTP | GTP-binding protein Rheb | / | 0.501 | |
| 3bbp | GTP | Ras-related protein Rab-6A | / | 0.500 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.498 | |
| 1k5d | GNP | GTP-binding nuclear protein Ran | / | 0.497 | |
| 4mit | GTP | Rho-related protein racC | / | 0.496 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.494 | |
| 2msd | GNP | MHC class I alpha chain | / | 0.494 | |
| 3kuc | GDP | Ras-related protein Rap-1A | / | 0.493 | |
| 1z0d | GDP | Ras-related protein Rab-5C | / | 0.490 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.490 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.489 | |
| 3bc1 | GNP | Ras-related protein Rab-27A | / | 0.489 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.488 | |
| 1oix | GDP | Ras-related protein Rab-11A | / | 0.488 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.488 | |
| 1v8k | ANP | Kinesin-like protein KIF2C | / | 0.487 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.485 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.483 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.483 | |
| 1jbp | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.480 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.480 | |
| 1z2a | GDP | Ras-related protein Rab-23 | / | 0.480 | |
| 3ict | ADP | Coenzyme A disulfide reductase | / | 0.479 | |
| 4cf8 | V7H | Integrase | / | 0.477 | |
| 5hpy | GDP | Transforming protein RhoA | / | 0.477 | |
| 4gzl | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.476 | |
| 4bn1 | ADP | Aurora kinase A | 2.7.11.1 | 0.475 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.474 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.474 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.473 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.473 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.472 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.472 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.471 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.471 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.470 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.470 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.470 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.470 | |
| 3wyf | GTP | GTP-binding nuclear protein | / | 0.470 | |
| 4cjq | VXO | Integrase | / | 0.470 | |
| 4ehv | 0SJ | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 4o2l | GTP | GTP-binding protein Rheb | / | 0.470 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.469 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.469 | |
| 4hyv | PEP | Pyruvate kinase 1 | 2.7.1.40 | 0.469 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.468 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.468 | |
| 2gzl | 2AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.467 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.467 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.467 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.466 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4bdr | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.466 | |
| 4cid | ANP | EH domain-containing protein 2 | / | 0.466 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.465 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.465 | |
| 2yg4 | FAD | Putrescine oxidase | / | 0.465 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.464 | |
| 4ge1 | TSS | Biogenic amine-binding protein | / | 0.464 | |
| 4yp7 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.464 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.464 | |
| 1efa | NPF | Lactose operon repressor | / | 0.463 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.463 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.463 | |
| 2c2a | ADP | Sensor histidine kinase | / | 0.463 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.463 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.463 | |
| 3cob | ADP | Kinesin heavy chain-like protein | / | 0.463 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.463 | |
| 4jau | ADP | Sensor histidine kinase | / | 0.463 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.463 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.462 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.462 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.462 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.461 | |
| 1z6l | FAD | Polyamine oxidase FMS1 | / | 0.461 | |
| 1z95 | 198 | Androgen receptor | / | 0.461 | |
| 4g01 | GDP | Ras-related protein RABF2b | / | 0.461 | |
| 1o01 | NAD | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.460 | |
| 2d4h | 5GP | Guanylate-binding protein 1 | / | 0.460 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.460 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.460 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.460 | |
| 1p0e | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.459 | |
| 4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 4eom | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.459 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.459 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.458 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.458 | |
| 2vo4 | GTB | 2,4-D inducible glutathione S-transferase | / | 0.458 | |
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.458 | |
| 4cf2 | 3GM | Integrase | / | 0.458 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.457 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1t90 | NAD | Malonate-semialdehyde dehydrogenase | 1.2.1.27 | 0.457 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.457 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.457 | |
| 3ac2 | KSE | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.457 | |
| 3q0g | COA | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.457 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.457 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.456 | |
| 2chl | DKI | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.456 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.456 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.456 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.456 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.456 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.455 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2c3i | IYZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.455 | |
| 2wpw | ACO | Orf14 | / | 0.455 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.455 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.455 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.455 | |
| 4ztv | TA7 | Anthranilate phosphoribosyltransferase | / | 0.455 | |
| 1e0j | ANP | DNA primase/helicase | 2.7.7 | 0.454 | |
| 1jsc | TPP | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.454 | |
| 1ow3 | GDP | Transforming protein RhoA | / | 0.454 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.454 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.454 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 4djx | 0KQ | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.454 | |
| 4okb | 198 | Androgen receptor | / | 0.454 | |
| 4pkw | GM6 | Lethal factor | 3.4.24.83 | 0.454 | |
| 4y0v | GDP | ADP-ribosylation factor 1, putative | / | 0.454 | |
| 1ii6 | ADP | Kinesin-like protein KIF11 | / | 0.453 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.453 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.453 | |
| 1z2c | GNP | Rho-related GTP-binding protein RhoC | / | 0.453 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.453 | |
| 3qlw | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.453 | |
| 4ag5 | ADP | Type IV secretory pathway VirB4 components-like protein | / | 0.453 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 4eh9 | 0OQ | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.452 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2az3 | CDP | Nucleoside diphosphate kinase | / | 0.452 | |
| 2g0l | FLN | Neocarzinostatin | / | 0.452 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2rl1 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.452 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.452 | |
| 4mzu | TYD | WxcM-like protein | / | 0.452 | |
| 4o4f | ATP | Kinase | / | 0.452 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.452 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.452 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1g9r | UPF | LgtC | / | 0.451 | |
| 1rp7 | TZD | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.451 | |
| 1svg | I04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 1z2n | ADP | Inositol-tetrakisphosphate 1-kinase | 2.7.1.134 | 0.451 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.451 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.451 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.451 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.451 | |
| 3ews | ADP | ATP-dependent RNA helicase DDX19B | 3.6.4.13 | 0.451 | |
| 3p2k | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.451 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.451 | |
| 3x0a | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.451 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.451 | |
| 5f0a | 1FB | cGMP-dependent protein kinase, putative | / | 0.451 | |
| 1uxn | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.450 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.450 | |
| 3gwn | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.450 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.450 | |
| 3pcg | 4HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.450 | |
| 3znq | SS8 | D-amino-acid oxidase | 1.4.3.3 | 0.450 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4ceq | QCH | Integrase | / | 0.450 | |
| 4ck2 | NVU | Integrase | / | 0.450 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.450 | |
| 4okx | 198 | Androgen receptor | / | 0.450 | |
| 4zm6 | ACO | N-acetyl-beta-D glucosaminidase | / | 0.450 | |
| 5iqg | GDP | Bifunctional AAC/APH | 2.3.1 | 0.450 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.450 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.450 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.449 | |
| 2i62 | SAH | Nicotinamide N-methyltransferase | 2.1.1.1 | 0.449 | |
| 2xvv | 9DN | Serum albumin | / | 0.449 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.449 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3ref | GDP | Rho family GTPase | / | 0.449 | |
| 4u0k | 744 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.449 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.448 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.448 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.448 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.448 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.448 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2j62 | GSZ | O-GlcNAcase NagJ | / | 0.448 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.448 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.448 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.448 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4lb2 | DM5 | Serum albumin | / | 0.448 | |
| 5di3 | GNP | ADP-ribosylation factor-like protein 3 | / | 0.448 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 1yre | COA | Uncharacterized protein | / | 0.447 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.447 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
| 2wu5 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.447 | |
| 2wu5 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.447 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 3q5d | GDP | Atlastin-1 | 3.6.5 | 0.447 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.447 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.447 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.447 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.447 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.446 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.446 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.446 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.446 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.445 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.445 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2bxq | IMN | Serum albumin | / | 0.445 | |
| 2h2j | SFG | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.445 | |
| 2qu5 | 276 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.445 | |
| 2r26 | CMC | Citrate synthase | 2.3.3.16 | 0.445 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 2xau | ADP | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 | 3.6.4.13 | 0.445 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.445 | |
| 4c2w | ANP | Aurora kinase B-A | 2.7.11.1 | 0.445 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.445 | |
| 4l9q | 9TP | Serum albumin | / | 0.445 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1g28 | FMN | PHY3 | / | 0.444 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.444 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.444 | |
| 2pup | ADP | Methylthioribose kinase | 2.7.1.100 | 0.444 | |
| 2tpr | FAD | Trypanothione reductase | 1.8.1.12 | 0.444 | |
| 2v7q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.444 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3dt2 | GTP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.444 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.444 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.444 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3rl3 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.444 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.444 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4ctj | SAM | Genome polyprotein | / | 0.444 | |
| 4iak | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.443 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.443 | |
| 1jlr | GTP | Uracil phosphoribosyltransferase | / | 0.443 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.443 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.443 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4cer | VL4 | Integrase | / | 0.443 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.443 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.442 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.442 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.442 | |
| 2bxm | IMN | Serum albumin | / | 0.442 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.442 | |
| 2h2e | SA8 | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.442 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.442 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.442 | |
| 2xxv | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.442 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3kro | IPE | Geranyl diphosphate synthase large subunit | / | 0.442 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.442 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.442 | |
| 3vi5 | M4M | Hematopoietic prostaglandin D synthase | / | 0.442 | |
| 3wqt | ANP | Cell division protein FtsA | / | 0.442 | |
| 3zv5 | BPY | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.442 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.442 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.442 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.441 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1vf2 | GTX | Glutathione S-transferase 3 | 2.5.1.18 | 0.441 | |
| 1vza | UMP | Thymidylate synthase | / | 0.441 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.441 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.441 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.441 | |
| 2g8d | UMP | Thymidylate synthase | / | 0.441 | |
| 2o12 | FMN | Chorismate synthase | / | 0.441 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.441 | |
| 3pft | FMN | Flavin reductase | / | 0.441 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.441 | |
| 3qfa | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.441 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.441 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.441 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4hvs | 647 | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.441 | |
| 4j52 | 1J3 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.441 | |
| 4kko | 1RE | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.441 | |
| 4okw | 198 | Androgen receptor | / | 0.441 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4tx9 | AMZ | Phosphoribosyl isomerase A | / | 0.441 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.441 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.440 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.440 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.440 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.440 | |
| 1rt7 | UC4 | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1tys | TMP | Thymidylate synthase | / | 0.440 | |
| 1z69 | F42 | 5,10-methylenetetrahydromethanopterin reductase | / | 0.440 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.440 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 3gb4 | D3M | DdmC | / | 0.440 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.440 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.440 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.440 | |
| 3tk0 | FAD | FAD-linked sulfhydryl oxidase ALR | 1.8.3.2 | 0.440 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.440 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
| 4cig | X0P | Integrase | / | 0.440 | |
| 4goj | GNP | ADP-ribosylation factor-like protein 3 | / | 0.440 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.440 | |
| 5iqa | GNP | Bifunctional AAC/APH | 2.3.1 | 0.440 |