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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o7uTHFThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4o7uTHFThymidylate synthase/1.000
1an5CB3Thymidylate synthase/0.569
3bgxMEFThymidylate synthase/0.562
3bhrTHGThymidylate synthase/0.542
1fwmCB3Thymidylate synthase/0.541
3bhlTHGThymidylate synthase/0.532
4gevCB3Thymidylate synthase/0.530
1tduCB3Thymidylate synthase/0.526
4knzCB3Thymidylate synthase/0.524
1tysDHFThymidylate synthase/0.515
4fogC2FThymidylate synthase ThyA/0.513
4ez8DHFThymidylate synthase2.1.1.450.503
4foxUMPThymidylate synthase ThyA/0.502
3uwlFOZThymidylate synthase/0.500
2ftoCB3Thymidylate synthase/0.493
1dduCB3Thymidylate synthase/0.482
1tduDURThymidylate synthase/0.471
1f4fTP3Thymidylate synthase/0.469
2vf0F89Thymidylate synthase/0.459
3bgxTMPThymidylate synthase/0.459
4isk1JYThymidylate synthase/0.454
1dduDDUThymidylate synthase/0.449
1f28UMPThymidylate synthase2.1.1.450.447
4einNOHThymidylate synthase2.1.1.450.444
1tysTMPThymidylate synthase/0.443