Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4o7n | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4o7n | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 1.000 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.600 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.561 | |
| 4o7l | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.558 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.505 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.504 | |
| 4l8u | 9AZ | Serum albumin | / | 0.498 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.497 | |
| 4nye | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.489 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.486 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.485 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.484 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.484 | |
| 4p5f | AR6 | Inosine-uridine nucleoside N-ribohydrolase | / | 0.484 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.483 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.482 | |
| 2x1e | X1E | Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form | 2.3.1.164 | 0.478 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.478 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.475 | |
| 5aga | ANP | DNA polymerase theta | / | 0.475 | |
| 1jm6 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.473 | |
| 1vce | SAH | Diphthine synthase | / | 0.473 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.473 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.473 | |
| 3bnk | FMN | Flavoredoxin | / | 0.473 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.472 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.472 | |
| 2g37 | FAD | Proline dehydrogenase | / | 0.471 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.471 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.471 | |
| 2y5s | 78H | Dihydropteroate synthase | / | 0.471 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.471 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 4tl7 | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.471 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.470 | |
| 4u0z | APC | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.470 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.469 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.469 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.468 | |
| 1v1a | KDG | 2-dehydro-3-deoxygluconokinase | 2.7.1.45 | 0.467 | |
| 2e07 | SAH | Diphthine synthase | / | 0.467 | |
| 5dn1 | AMZ | Phosphoribosyl isomerase A | 5.3.1.16 | 0.467 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.466 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.466 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.465 | |
| 1xuz | MMN | Capsule biosynthesis protein | / | 0.465 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.465 | |
| 2z02 | ATP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.465 | |
| 3gue | UPG | UTP-glucose-1-phosphate uridylyltransferase 2, putative | / | 0.465 | |
| 4b6s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.465 | |
| 1d7a | AIR | N5-carboxyaminoimidazole ribonucleotide mutase | / | 0.464 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.464 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.464 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4g73 | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.464 | |
| 2ejz | SAH | Diphthine synthase | / | 0.463 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.463 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.463 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.463 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.462 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.461 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.461 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.460 | |
| 1lny | IMO | Adenylosuccinate synthetase isozyme 1 | / | 0.459 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.459 | |
| 4die | C5P | Cytidylate kinase | / | 0.459 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.459 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.458 | |
| 1in5 | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.458 | |
| 1m67 | BOA | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.458 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.458 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.458 | |
| 2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.458 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.458 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.458 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.458 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.458 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.458 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.458 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.457 | |
| 2el0 | SAH | Diphthine synthase | / | 0.457 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.457 | |
| 3up0 | D7S | aceDAF-12 | / | 0.457 | |
| 4da8 | BG2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.457 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.456 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.456 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.456 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.456 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.456 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.456 | |
| 5byl | GCP | Bifunctional AAC/APH | 2.3.1 | 0.456 | |
| 1bpw | NAD | Betaine aldehyde dehydrogenase | 1.2.1.8 | 0.455 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.455 | |
| 2dsg | SAH | Diphthine synthase | / | 0.455 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.455 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 4cjw | CBJ | Integrase | / | 0.455 | |
| 4ehz | JAK | Tyrosine-protein kinase JAK1 | / | 0.455 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.455 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.455 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.455 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.454 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.454 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 2f6r | ACO | Bifunctional coenzyme A synthase | / | 0.454 | |
| 2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.454 | |
| 3d83 | GK6 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.454 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.454 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.454 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.454 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.453 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.453 | |
| 1zdw | FLV | Prenyltransferase | / | 0.453 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.453 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.453 | |
| 3fx6 | BPX | Carboxypeptidase A1 | 3.4.17.1 | 0.453 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.453 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.453 | |
| 4nmc | FAD | Bifunctional protein PutA | / | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.452 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.452 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.452 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.452 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 3of4 | FMN | Nitroreductase | / | 0.452 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.452 | |
| 4jxr | ACO | Acetyltransferase | / | 0.452 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.451 | |
| 1tys | TMP | Thymidylate synthase | / | 0.451 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.451 | |
| 2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.451 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.451 | |
| 4e03 | ADP | Plasmid partitioning protein ParF | / | 0.451 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.451 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.451 | |
| 4gap | NAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.451 | |
| 5cyo | GDP | Septin-9 | / | 0.451 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.451 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.450 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.450 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.450 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.450 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
| 1z4u | PH9 | Polyprotein | / | 0.450 | |
| 2egl | SAH | Diphthine synthase | / | 0.450 | |
| 2en5 | SAH | Diphthine synthase | / | 0.450 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.450 | |
| 2mm3 | CHO | Gastrotropin | / | 0.450 | |
| 2owf | SAH | Diphthine synthase | / | 0.450 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.450 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.450 | |
| 3s1a | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.450 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.450 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.450 | |
| 4l4x | NDP | AmphI | / | 0.450 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 5doz | NDP | JamJ | / | 0.450 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.449 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 2ejk | SAH | Diphthine synthase | / | 0.449 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 2qg4 | NAD | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.449 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.449 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.449 | |
| 3hy3 | 10F | 5-formyltetrahydrofolate cyclo-ligase | 6.3.3.2 | 0.449 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.449 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4hxy | NDP | Plm1 | / | 0.449 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.449 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.448 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.448 | |
| 1zar | ADP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.448 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.448 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.448 | |
| 2pci | SAH | Diphthine synthase | / | 0.448 | |
| 2pcm | SAH | Diphthine synthase | / | 0.448 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.448 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.448 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.448 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 4mwz | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.448 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.448 | |
| 1dfo | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.447 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.447 | |
| 1krv | 147 | Galactoside O-acetyltransferase | 2.3.1.18 | 0.447 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.447 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.447 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.447 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.447 | |
| 2bjh | FER | Feruloyl esterase A | 3.1.1.73 | 0.447 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.447 | |
| 2rg5 | 279 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2yqz | SAM | Uncharacterized protein | / | 0.447 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.447 | |
| 2zxu | DST | tRNA dimethylallyltransferase | 2.5.1.75 | 0.447 | |
| 3a8t | ATP | Adenylate isopentenyltransferase | / | 0.447 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.447 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.447 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3qi2 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.447 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.447 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4hj6 | FMN | LOV protein | / | 0.447 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.447 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.447 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.446 | |
| 1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.446 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.446 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 2dxw | SAH | Diphthine synthase | / | 0.446 | |
| 2e08 | SAH | Diphthine synthase | / | 0.446 | |
| 2e8q | SAH | Diphthine synthase | / | 0.446 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.446 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.446 | |
| 2qxx | TTP | dCTP deaminase | 3.5.4.13 | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.446 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.446 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.446 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4f6s | 0SQ | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.446 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.446 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 4l9q | 9TP | Serum albumin | / | 0.446 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.446 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.445 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.445 | |
| 1k8y | 13P | Tryptophan synthase alpha chain | / | 0.445 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
| 2du8 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.445 | |
| 2dxv | SAH | Diphthine synthase | / | 0.445 | |
| 2e17 | SAH | Diphthine synthase | / | 0.445 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.445 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.445 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.445 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.445 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.445 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.445 | |
| 3p3c | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.445 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 0.445 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.445 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.445 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.445 | |
| 5buk | FAD | FADH2-dependent halogenase | / | 0.445 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1bxr | ANP | Carbamoyl-phosphate synthase large chain | / | 0.444 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.444 | |
| 1jje | BYS | Beta-lactamase | / | 0.444 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 1swt | BTN | Streptavidin | / | 0.444 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.444 | |
| 2c4j | GSO | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.444 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.444 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.444 | |
| 2nli | FMN | Lactate oxidase | / | 0.444 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.444 | |
| 2ves | GVR | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.444 | |
| 3rbq | GLY_ALA_GLY_DAO | Protein unc-119 homolog A | / | 0.444 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.444 | |
| 3uth | GDU | UDP-galactopyranose mutase | / | 0.444 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.444 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.444 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4ho8 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.444 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.444 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.444 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.444 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1lvg | 5GP | Guanylate kinase | 2.7.4.8 | 0.443 | |
| 1mra | APG | Mandelate racemase | / | 0.443 | |
| 1o5i | NAD | 3-oxoacyl-(Acyl carrier protein) reductase | / | 0.443 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.443 | |
| 2ek3 | SAH | Diphthine synthase | / | 0.443 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.443 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.443 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.443 | |
| 3kt8 | LTN | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.443 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.443 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.443 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.443 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.443 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.443 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.443 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.443 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.443 | |
| 5dro | ZH2 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.443 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 1f0y | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.442 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 2fyp | RDE | Endoplasmin | / | 0.442 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4iax | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.442 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.442 | |
| 4lsl | 1YQ | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.442 | |
| 4ng2 | OHN | Transcriptional activator protein LasR | / | 0.442 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.442 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.442 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.441 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.441 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.441 | |
| 2e15 | SAH | Diphthine synthase | / | 0.441 | |
| 2e4n | SAH | Diphthine synthase | / | 0.441 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.441 | |
| 2h2a | DND | Probable nicotinate-nucleotide adenylyltransferase | / | 0.441 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.441 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.441 | |
| 3e8n | VRA | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.441 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3qtu | X44 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.441 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.441 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.441 | |
| 4hjf | C2E | GGDEF family protein | / | 0.441 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.441 | |
| 4xba | 5GP | Aprataxin-like protein | 3 | 0.441 | |
| 5c3j | UQ1 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | / | 0.441 | |
| 5c3j | UQ1 | Succinate dehydrogenase cytochrome b560 | / | 0.441 | |
| 5di3 | GNP | ADP-ribosylation factor-like protein 3 | / | 0.441 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.441 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.440 | |
| 1vrq | FMN | Subunit alpha of sarocosine oxidase | / | 0.440 | |
| 1vrq | FMN | Subunit beta of sarcosine oxidase | / | 0.440 | |
| 1xdp | ATP | Polyphosphate kinase | / | 0.440 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.440 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.440 | |
| 2e1z | B4P | Propionate kinase | / | 0.440 | |
| 2gbl | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.440 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.440 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.440 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.440 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4cf1 | IY7 | Integrase | / | 0.440 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.440 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.440 | |
| 4rkd | KET | Aminotransferase | / | 0.440 | |
| 5c4c | UPG | Histo-blood group ABO system transferase | / | 0.440 | |
| 4z36 | ON3 | Lysophosphatidic acid receptor 1 | / | 0.440 |