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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o2lGTPGTP-binding protein Rheb

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4o2lGTPGTP-binding protein Rheb/1.000
1xtsGTPGTP-binding protein Rheb/0.575
1xtrGNPGTP-binding protein Rheb/0.568
3kkoGNPRas-related protein M-Ras/0.558
3pitGNPRas-related protein M-Ras/0.555
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.547
3lbhGNPGTPase HRas/0.545
3oesGNPGTPase RhebL1/0.545
3ddcGNPGTPase HRas/0.543
4o2rGDPGTP-binding protein Rheb/0.542
3a6pGTPGTP-binding nuclear protein Ran/0.541
4g0nGNPGTPase HRas/0.540
1ibrGNPGTP-binding nuclear protein Ran/0.534
3bbpGTPRas-related protein Rab-6A/0.533
3lbnGNPGTPase HRas/0.533
1d5cGDPGTPase (Rab6)/0.529
5difGNPGTP-binding nuclear protein Ran/0.529
4dsnGCPGTPase KRas/0.528
3w3zGTPGTP-binding nuclear protein Ran/0.525
1t91GTPRas-related protein Rab-7a/0.521
3e5hGNPRas-related protein Rab-28/0.521
3k8yGNPGTPase HRas/0.521
3kz1GSPTransforming protein RhoA/0.521
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.521
5dhaGNPGTP-binding nuclear protein Ran/0.521
4hdoGNPRas-related protein Rap-1b/0.520
2rgcGNPGTPase HRas/0.517
2rgeGNPGTPase HRas/0.516
1yhnGTPRas-related protein Rab-7a/0.515
4mitGTPRho-related protein racC/0.513
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.512
1yzqGNPRas-related protein Rab-6A/0.511
3eg5GNPCell division control protein 42 homolog/0.511
3rs0GNPGTPase HRas/0.510
5b2zGNPGTPase HRas/0.510
2fe4GDPRas-related protein Rab-6B/0.509
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.509
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.508
4dltGNPGTPase HRas/0.508
3oivGNPGTPase HRas/0.507
3v4fGNPGTPase HRas/0.507
1e96GTPRas-related C3 botulinum toxin substrate 1/0.504
2c5lGTPGTPase HRas/0.503
3wyfGTPGTP-binding nuclear protein/0.502
3lbiGNPGTPase HRas/0.501
4nyjGNPGTPase HRas/0.500
1kmqGNPTransforming protein RhoA/0.499
2rgbGNPGTPase HRas/0.499
2bkuGTPGTP-binding nuclear protein Ran/0.498
3kucGDPRas-related protein Rap-1A/0.498
4rkfGNPRas-related protein Rab-3/0.498
1z2aGDPRas-related protein Rab-23/0.497
2ffqGSPRas-related protein Rab-6B/0.497
3ea5GDPGTP-binding nuclear protein Ran/0.497
3l8yGNPGTPase HRas/0.496
3rs4GNPGTPase HRas/0.496
4ol0GTPGTP-binding nuclear protein Ran/0.495
1cxzGSPTransforming protein RhoA/0.494
3x1zGNPRas-related protein Rap-1b/0.493
3rslGNPGTPase HRas/0.492
4tq9GDPGTPase KRas/0.488
4o25GTPGTP-binding protein Rheb/0.487
3oiuGNPGTPase HRas/0.486
3oiwGNPGTPase HRas/0.486
3nbzGTPGTP-binding nuclear protein Ran/0.484
4dlsGNPGTPase HRas/0.484
1vg8GNPRas-related protein Rab-7a/0.483
1k5dGNPGTP-binding nuclear protein Ran/0.481
4l8gGDPGTPase KRas/0.481
1zd9GDPADP-ribosylation factor-like protein 8A/0.480
4js0GNPCell division control protein 42 homolog/0.479
2msdGNPMHC class I alpha chain/0.478
4dlwGNPGTPase HRas/0.478
3rs7GNPGTPase HRas/0.477
3rabGNPRas-related protein Rab-3A/0.475
3rs5GNPGTPase HRas/0.475
3a58GNPGTP-binding protein RHO1/0.474
1g17GNPRas-related protein SEC4/0.473
1zc4GNPRas-related protein Ral-A/0.473
3i3sGNPGTPase HRas/0.473
2rggGNPGTPase HRas/0.472
3qbtGNPRas-related protein Rab-8A/0.472
4dlxGNPGTPase HRas/0.472
3tgpGNPGTPase HRas/0.471
3kudGDPGTPase HRas/0.470
4dlvGNPGTPase HRas/0.470
4hdqGNPRas-related protein Rap-1b/0.469
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.468
3kkqGDPRas-related protein M-Ras/0.467
4dlzGNPGTPase HRas/0.467
4lucGDPGTPase KRas/0.466
4l9sGDPGTPase HRas/0.464
4wa7GDPGTPase KRas/0.464
3cphGDPRas-related protein SEC4/0.463
4xvqGNPGTPase HRas/0.463
1a2bGSPTransforming protein RhoA/0.462
1m7bGTPRho-related GTP-binding protein RhoE/0.462
4l9wGNPGTPase HRas/0.461
1x1rGDPRas-related protein M-Ras/0.460
1n6lGTPRas-related protein Rab-5A/0.457
3dr7GPDGDP-perosamine synthase/0.457
4lpkGDPGTPase KRas/0.457
2fg5GNPRas-related protein Rab-31/0.456
4dsoGSPGTPase KRas/0.453
4xbfFADLysine-specific histone demethylase 1A10.453
3akm11DFatty acid-binding protein, intestinal/0.452
4xvrGNPGTPase HRas/0.452
1yu9GNPRas-related protein Rab-4A/0.450
4k81GTPGTPase HRas/0.449
1s1cGNPTransforming protein RhoA/0.446
4q03GDPGTPase KRas/0.444
2ce2GDPGTPase HRas/0.443
3ipuO40Oxysterols receptor LXR-alpha/0.440
4epwGDPGTPase KRas/0.440
4lv6GDPGTPase KRas/0.440