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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o25GTPGTP-binding protein Rheb

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4o25GTPGTP-binding protein Rheb/1.000
3e5hGNPRas-related protein Rab-28/0.581
3oesGNPGTPase RhebL1/0.549
1xtsGTPGTP-binding protein Rheb/0.548
1yzqGNPRas-related protein Rab-6A/0.544
1yhnGTPRas-related protein Rab-7a/0.533
1t91GTPRas-related protein Rab-7a/0.532
4kvgGTPRas-related protein Rap-1A/0.530
2ffqGSPRas-related protein Rab-6B/0.525
1xtrGNPGTP-binding protein Rheb/0.524
3tsoGNPRas-related protein Rab-25/0.523
3bbpGTPRas-related protein Rab-6A/0.521
1vg8GNPRas-related protein Rab-7a/0.512
3lawGNPRas-related protein Rab-7a/0.512
5dhaGNPGTP-binding nuclear protein Ran/0.512
1zbdGTPRas-related protein Rab-3A/0.510
1zc3GNPRas-related protein Ral-A/0.510
4qxaGTPRas-related protein Rab-9A/0.500
3rs5GNPGTPase HRas/0.499
3v4fGNPGTPase HRas/0.499
1kmqGNPTransforming protein RhoA/0.496
2zetGTPRas-related protein Rab-27B/0.496
3lbnGNPGTPase HRas/0.496
4lhwGNPRas-related protein Rab-8A/0.493
3rabGNPRas-related protein Rab-3A/0.490
3bc1GNPRas-related protein Rab-27A/0.488
4cymGCPRas-related protein Rab-32/0.486
4rkfGNPRas-related protein Rab-3/0.483
1lfdGNPGTPase HRas/0.481
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.480
3oiuGNPGTPase HRas/0.480
3oivGNPGTPase HRas/0.479
5hpyGDPTransforming protein RhoA/0.479
4nyiGNPGTPase HRas/0.478
1g17GNPRas-related protein SEC4/0.476
1zc4GNPRas-related protein Ral-A/0.476
3eg5GNPCell division control protein 42 homolog/0.476
1ow3GDPTransforming protein RhoA/0.475
4tyqAP5Adenylate kinase/0.474
3ea5GDPGTP-binding nuclear protein Ran/0.471
1cxzGSPTransforming protein RhoA/0.467
5c46GSPRas-related protein Rab-11A/0.465
1z2cGNPRho-related GTP-binding protein RhoC/0.464
3tnfGNPRas-related protein Rab-8A/0.463
3w3zGTPGTP-binding nuclear protein Ran/0.463
4uj5GNPRas-related protein Rab-11A/0.463
1s1cGNPTransforming protein RhoA/0.462
4dxaGSPRas-related protein Rap-1b/0.462
4nyjGNPGTPase HRas/0.462
5jljGNPGTP-binding nuclear protein Ran/0.461
4mitGTPRho-related protein racC/0.460
3kz1GSPTransforming protein RhoA/0.459
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.458
1ibrGNPGTP-binding nuclear protein Ran/0.457
3cphGDPRas-related protein SEC4/0.455
4uj3GNPRas-related protein Rab-11A/0.455
1uadGNPRas-related protein Ral-A/0.454
1k5dGNPGTP-binding nuclear protein Ran/0.452
3i3sGNPGTPase HRas/0.450
3ddcGNPGTPase HRas/0.449
3tklGTPRas-related protein Rab-1A/0.447
1e96GTPRas-related C3 botulinum toxin substrate 1/0.446
4js0GNPCell division control protein 42 homolog/0.446
4nvk2NYPeroxidase/0.446
3wqmB29Diterpene synthase3.1.7.80.445
3kucGDPRas-related protein Rap-1A/0.444
3a58GNPGTP-binding protein RHO1/0.441
5b2zGNPGTPase HRas/0.441
2bkuGTPGTP-binding nuclear protein Ran/0.440