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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nvq2ODHistone-lysine N-methyltransferase EHMT2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4nvq2ODHistone-lysine N-methyltransferase EHMT2/1.000
3mo5E72Histone-lysine N-methyltransferase EHMT1/0.568
3mo0E11Histone-lysine N-methyltransferase EHMT1/0.536
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.514
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.493
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.491
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.486
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.478
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.470