sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4nu0 | AP5 | Adenylate kinase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4nu0 | AP5 | Adenylate kinase | / | 1.000 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.648 | |
| 4qbi | AP5 | Adenylate kinase | / | 0.628 | |
| 3dkv | AP5 | Adenylate kinase | / | 0.621 | |
| 3hpq | AP5 | Adenylate kinase | / | 0.616 | |
| 1ake | AP5 | Adenylate kinase | / | 0.614 | |
| 4jld | ADP | Adenylate kinase | / | 0.609 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.603 | |
| 2qaj | AP5 | Adenylate kinase | / | 0.591 | |
| 2eu8 | AP5 | Adenylate kinase | / | 0.590 | |
| 4x8o | AP5 | Adenylate kinase | / | 0.590 | |
| 4jlo | ADP | Adenylate kinase | / | 0.584 | |
| 1p3j | AP5 | Adenylate kinase | / | 0.569 | |
| 4jl5 | ADP | Adenylate kinase | / | 0.567 | |
| 2rgx | AP5 | Adenylate kinase | / | 0.566 | |
| 4qbh | AP5 | Adenylate kinase | / | 0.564 | |
| 1ank | ANP | Adenylate kinase | / | 0.562 | |
| 2eck | ADP | Adenylate kinase | / | 0.560 | |
| 4x8l | AP5 | Adenylate kinase | / | 0.547 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.544 | |
| 4jky | ADP | Adenylate kinase | / | 0.543 | |
| 4ike | ADP | Adenylate kinase | / | 0.538 | |
| 2aky | AP5 | Adenylate kinase | / | 0.532 | |
| 1zio | AP5 | Adenylate kinase | / | 0.530 | |
| 4mkh | AP5 | Adenylate kinase | / | 0.518 | |
| 4qbf | AP5 | Adenylate kinase | / | 0.514 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.500 | |
| 1p4a | PCP | Pur operon repressor | / | 0.497 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.494 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.492 | |
| 2olr | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.491 | |
| 4ie0 | PD2 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.491 | |
| 2cbs | R13 | Cellular retinoic acid-binding protein 2 | / | 0.487 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.486 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.484 | |
| 2py7 | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.484 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.483 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.483 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.482 | |
| 1esv | LAR | Actin, alpha skeletal muscle | / | 0.481 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.480 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.480 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.479 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.479 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.479 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.479 | |
| 4die | C5P | Cytidylate kinase | / | 0.478 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.476 | |
| 4nvk | 2NY | Peroxidase | / | 0.474 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.473 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.473 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.473 | |
| 1ytm | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.472 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.472 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.472 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.472 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.471 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.471 | |
| 2bun | FAD | AppA protein | / | 0.470 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.470 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.469 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.469 | |
| 4hs4 | FMN | Chromate reductase | / | 0.469 | |
| 4loh | 1SY | Stimulator of interferon genes protein | / | 0.469 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.469 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.468 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.468 | |
| 3up0 | D7S | aceDAF-12 | / | 0.468 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.468 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.467 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.467 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.467 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.467 | |
| 1yba | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.466 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.466 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.466 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.465 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.465 | |
| 1g9c | BAB | Botulinum neurotoxin type B | 3.4.24.69 | 0.465 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.465 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.465 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.465 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.464 | |
| 1k27 | MTM | S-methyl-5'-thioadenosine phosphorylase | / | 0.463 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.463 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.463 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.463 | |
| 4f5d | C2E | Stimulator of interferon genes protein | / | 0.463 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.462 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.462 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.461 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.461 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.461 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.461 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.461 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.460 | |
| 2gmj | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.460 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.460 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.460 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.460 | |
| 3x2v | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.460 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.460 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1vfr | FMN | Major NAD(P)H-flavin oxidoreductase | 1.6.99 | 0.459 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.459 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.459 | |
| 3lmg | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.459 | |
| 4ftq | 4HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.459 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.458 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.458 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.458 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.457 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2wms | ZYS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.457 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3uce | NDP | Dehydrogenase | / | 0.457 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.457 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.457 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2yer | TQ1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.456 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.456 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.456 | |
| 4qms | 1N1 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.456 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.455 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.455 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.455 | |
| 1bcp | ATP | Pertussis toxin subunit 4 | / | 0.454 | |
| 1bcp | ATP | Pertussis toxin subunit 5 | / | 0.454 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.454 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.454 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.454 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.454 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1cg3 | IMO | Adenylosuccinate synthetase | / | 0.453 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.453 | |
| 2ek2 | SAH | Diphthine synthase | / | 0.453 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.453 | |
| 2rm2 | W43 | Genome polyprotein | / | 0.453 | |
| 3buz | LAR | Actin, alpha skeletal muscle | / | 0.453 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.453 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.453 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.453 | |
| 4x30 | T44 | Thyroxine-binding globulin | / | 0.453 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.453 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.452 | |
| 3vcy | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.452 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.452 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.452 | |
| 4dzz | ADP | Plasmid partitioning protein ParF | / | 0.452 | |
| 4ram | PNM | Metallo-beta-lactamase type 2 | / | 0.452 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.452 | |
| 5dby | NPS | Serum albumin | / | 0.452 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.452 | |
| 1f9a | ATP | Nicotinamide-nucleotide adenylyltransferase | / | 0.451 | |
| 1i2l | DCS | Aminodeoxychorismate lyase | 4.1.3.38 | 0.451 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3c1o | NAP | Eugenol synthase | / | 0.451 | |
| 3fmh | 533 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.451 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.451 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.451 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.450 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.450 | |
| 4bqw | QNM | Egl nine homolog 1 | / | 0.450 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.450 | |
| 1nlm | UD1 | UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase | / | 0.449 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.449 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.449 | |
| 2g1m | 4HG | Egl nine homolog 1 | / | 0.449 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.449 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.449 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4eo3 | FMN | Bacterioferritin comigratory protein/NADH dehydrogenase | / | 0.449 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.449 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.448 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.448 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.448 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.448 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.448 | |
| 2vhz | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.448 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.448 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 4l4x | NDP | AmphI | / | 0.448 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.448 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.447 | |
| 1qvn | FRI | Interleukin-2 | / | 0.447 | |
| 1sny | NAP | LD36273p | / | 0.447 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.447 | |
| 2o12 | FMN | Chorismate synthase | / | 0.447 | |
| 2od7 | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.447 | |
| 3b7k | COA | Acyl-coenzyme A thioesterase 12 | 3.1.2.1 | 0.447 | |
| 3i0a | DBH | Neutrophil gelatinase-associated lipocalin | / | 0.447 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 4lhv | GDP | Ras-related protein Rab-8A | / | 0.447 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 4ysw | FAD | Xanthine dehydrogenase/oxidase | / | 0.447 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.447 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.447 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.446 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.446 | |
| 1lrk | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 2eka | SAH | Diphthine synthase | / | 0.446 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.446 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.446 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.446 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.446 | |
| 3v49 | PK0 | Androgen receptor | / | 0.446 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 4okx | 198 | Androgen receptor | / | 0.446 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.445 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.445 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.445 | |
| 1lke | DOG | Bilin-binding protein | / | 0.445 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.445 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.445 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.445 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.445 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 4cj4 | S3G | Integrase | / | 0.445 | |
| 4jc5 | 1K5 | Stimulator of interferon genes protein | / | 0.445 | |
| 4kin | 1M8 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.445 | |
| 4p13 | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.445 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.444 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.444 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.444 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.444 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.444 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 3fql | 79Z | Genome polyprotein | 2.7.7.48 | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.444 | |
| 3ivm | ZPR | Prolyl endopeptidase | / | 0.444 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3o3p | GDD | Glycosyl transferase, family 2 | / | 0.444 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.444 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.444 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.444 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1jnk | ANP | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 1s4e | ADP | Galactokinase | / | 0.443 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.443 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.443 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.443 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.443 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.443 | |
| 2r6g | ATP | Maltose/maltodextrin import ATP-binding protein MalK | / | 0.443 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.443 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.443 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.443 | |
| 2y3p | SM8 | DNA gyrase subunit A | / | 0.443 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3pcn | DHY | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.443 | |
| 3pcn | DHY | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.443 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.443 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.443 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4yp1 | 2BA | Stimulator of interferon genes protein | / | 0.443 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.443 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.443 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.442 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.442 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.442 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1vce | SAH | Diphthine synthase | / | 0.442 | |
| 2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.442 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3au2 | DGT | DNA polymerase beta family (X family) | / | 0.442 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.442 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.442 | |
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.442 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 4aa5 | NQB | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4afh | L0B | Achbp | / | 0.442 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.442 | |
| 4guk | P2G | Neuronal calcium sensor 1 | / | 0.442 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.442 | |
| 4riy | ANP | Receptor tyrosine-protein kinase erbB-3 | 2.7.10.1 | 0.442 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.442 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.441 | |
| 1gve | NAP | Aflatoxin B1 aldehyde reductase member 3 | 1 | 0.441 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.441 | |
| 1r37 | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 2egs | SAH | Diphthine synthase | / | 0.441 | |
| 2h59 | APR | NAD-dependent protein deacetylase | / | 0.441 | |
| 2nom | DUT | Poly(A) polymerase, putative | / | 0.441 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.441 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.441 | |
| 2x4z | X4Z | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.441 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.441 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.441 | |
| 3n8n | N88 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.441 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.441 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 4bzq | ADP | Bifunctional enzyme CysN/CysC | 2.7.1.25 | 0.441 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.441 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4in4 | 4ID | Kelch-like ECH-associated protein 1 | / | 0.441 | |
| 4loo | SB4 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4qxp | 1YE | Stimulator of interferon genes protein | / | 0.441 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.441 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.440 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1w1w | AGS | Structural maintenance of chromosomes protein 1 | / | 0.440 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.440 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.440 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.440 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.440 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3flz | FLZ | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.440 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.440 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.440 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.440 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3pch | CHB | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.440 | |
| 3pzc | COA | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 4ebf | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.440 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 4l82 | FMN | Uncharacterized protein | / | 0.440 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.440 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.440 | |
| 4qvb | F42 | F420H(2)-dependent reductase Rv1155 | 1.4.3.5 | 0.440 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.440 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.440 |