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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nr82LLBromodomain-containing protein 4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4nr82LLBromodomain-containing protein 4/1.000
4c67L5SBromodomain-containing protein 4/0.600
4hxm1A8Bromodomain-containing protein 4/0.592
4cfkLY2Bromodomain-containing protein 4/0.582
4hxr1A4Bromodomain-containing protein 4/0.581
4gpj0Q1Bromodomain-containing protein 4/0.565
4lyw21QBromodomain-containing protein 4/0.538
4hbw14ZBromodomain-containing protein 4/0.537
5bt52LOBromodomain-containing protein 2/0.536
4nyw2O3CREB-binding protein/0.510
4alg1GHBromodomain-containing protein 2/0.508
4j1p1K0Bromodomain-containing protein 2/0.498
4py6R78Bromodomain protein, putative/0.498
4a9iP9IBromodomain-containing protein 2/0.496
4alhA9PBromodomain-containing protein 2/0.496
1heuNADAlcohol dehydrogenase E chain1.1.1.10.489
4bw39BMBromodomain-containing protein 4/0.485
3ffi3OBGag-Pol polyprotein2.7.7.490.480
1bwsNDPGDP-L-fucose synthase/0.479
3svgODRBromodomain-containing protein 4/0.478
3aqaBYHBromodomain-containing protein 2/0.477
1tj0FADBifunctional protein PutA1.5.5.20.476
4hby13FBromodomain-containing protein 4/0.476
4ir5IR5Bromodomain adjacent to zinc finger domain protein 2B/0.473
3zyu1GHBromodomain-containing protein 4/0.472
4nqmY1ZBromodomain-containing protein 4/0.472
4meo25VBromodomain-containing protein 4/0.471
2rewREWPeroxisome proliferator-activated receptor alpha/0.470
4e960NSBromodomain-containing protein 4/0.470
3tqhNDPQuinone oxidoreductase/0.469
4bjx73BBromodomain-containing protein 4/0.468
4pkl1GHUncharacterized protein/0.467
3uvqFS8Mitogen-activated protein kinase 14/0.466
4j0s1H3Bromodomain-containing protein 4/0.466
5kj6NAJAlcohol dehydrogenase E chain1.1.1.10.465
3stv3HOMethylketone synthase I/0.463
4bw1S5BBromodomain-containing protein 4/0.463
4men25KBromodomain-containing protein 4/0.462
4a9lP9LBromodomain-containing protein 4/0.461
4ia2BIVVitamin D3 receptor A/0.461
5cdgNAJAlcohol dehydrogenase E chain1.1.1.10.460
1q0qNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.459
2dbrNAPGlyoxylate reductase1.1.1.260.459
3wmxNADNAD dependent epimerase/dehydratase/0.459
4o74R78Bromodomain-containing protein 4/0.459
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.458
2q61SF1Peroxisome proliferator-activated receptor gamma/0.457
2w98P1ZProstaglandin reductase 21.3.1.480.457
4ogiR78Bromodomain-containing protein 4/0.457
4uyg73BBromodomain-containing protein 2/0.457
5fm7ADPRuvB-like helicase/0.457
1jolFFODihydrofolate reductase1.5.1.30.455
2i4qUA4Renin3.4.23.150.455
4bw49B6Bromodomain-containing protein 4/0.455
4lrg1XBBromodomain-containing protein 4/0.455
5dfcEAMBromodomain-containing protein 2/0.455
4a9nA9NBromodomain-containing protein 2/0.454
4hxs1A3Bromodomain-containing protein 4/0.454
4mr41K0Bromodomain-containing protein 4/0.454
4xxvNAD3-isopropylmalate dehydrogenase/0.454
5itzLOCTubulin beta-2B chain/0.454
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.453
1wygFADXanthine dehydrogenase/oxidase/0.452
2lf1NDPDihydrofolate reductase1.5.1.30.452
4a9oA9OBromodomain-containing protein 2/0.452
3oq6NAJAlcohol dehydrogenase E chain1.1.1.10.451
4mr51K0Bromodomain-containing protein 2/0.451
5cdtPFBAlcohol dehydrogenase E chain1.1.1.10.451
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.450
3wleNAD(R)-specific carbonyl reductase/0.450
4mep24YBromodomain-containing protein 4/0.450
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.450
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.450
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.449
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.449
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.449
4bw2UTHBromodomain-containing protein 4/0.449
5cdsPFBAlcohol dehydrogenase E chain1.1.1.10.449
5kjeNAJAlcohol dehydrogenase E chain1.1.1.10.449
3fl9TOPDihydrofolate reductase/0.448
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
4o78SAVBromodomain-containing protein 4/0.448
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.448
5bsfNADPyrroline-5-carboxylate reductase/0.448
1hdoNAPFlavin reductase (NADPH)/0.447
1rf7DHFDihydrofolate reductase1.5.1.30.447
2eauCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.447
2znnS44Peroxisome proliferator-activated receptor alpha/0.447
3tscNADUncharacterized protein/0.447
4lr61XABromodomain-containing protein 4/0.447
5dldUD1UDP-N-Acetylglucosamine 2-epimerase/0.447
1ezfIN0Squalene synthase2.5.1.210.446
1k6pXN3Gag-Pol polyprotein3.4.23.160.446
1fm9570Peroxisome proliferator-activated receptor gamma/0.445
1j39UPGDNA beta-glucosyltransferase/0.445
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.445
3t37FADPyridoxine 4-oxidase/0.445
4aknS5BBromodomain-containing protein 2/0.445
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.443
2gjnFMNNitronate monooxygenase1.13.12.160.443
2tctCTCTetracycline repressor protein class D/0.443
2vkuDBELanosterol 14-alpha demethylase1.14.13.700.443
3qlrNDPDihydrofolate reductase1.5.1.30.443
4h4yNAPBiphenyl dioxygenase ferredoxin reductase subunit/0.443
4j0r1H2Bromodomain-containing protein 4/0.443
3gncQQQGlutaryl-CoA dehydrogenase/0.442
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.442
4o4eATPKinase/0.442
1draMTXDihydrofolate reductase1.5.1.30.441
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
3fznD7KBenzoylformate decarboxylase4.1.1.70.441
3k4nFADPyranose 2-oxidase/0.441
3lu6IMXSerum albumin/0.441
3q43D66M1 family aminopeptidase3.4.110.441
4mr61K0Bromodomain-containing protein 2/0.441
5kjcPFBAlcohol dehydrogenase E chain1.1.1.10.441
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.440
1jpaANPEphrin type-B receptor 22.7.10.10.440
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.440
3cgcFADCoenzyme A disulfide reductase/0.440
4nr52LLCREB-binding protein/0.440
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.440