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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.261.000
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.716
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.637
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.635
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.546
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.524
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.517
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.515
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.510
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.510
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.501
3du8553Glycogen synthase kinase-3 beta2.7.11.260.500
2qo9ANPEphrin type-A receptor 32.7.10.10.495
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.495
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.494
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.493
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.492
4riyADPEpidermal growth factor receptor2.7.10.10.488
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.487
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.487
4ii5ADPCyclin-dependent kinase 22.7.11.220.485
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.484
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.484
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.479
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.477
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.477
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.476
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.472
1qmzATPCyclin-dependent kinase 22.7.11.220.471
1gy3ATPCyclin-dependent kinase 22.7.11.220.470
4qmlANPSerine/threonine-protein kinase 242.7.11.10.466
2py3ACPFibroblast growth factor receptor 2/0.465
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.462
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.462
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.460
4eooATPCyclin-dependent kinase 22.7.11.220.460
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.460
4wboANWRhodopsin kinase/0.460
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.459
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.457
2cchATPCyclin-dependent kinase 22.7.11.220.456
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.455
4jrnANPRhoptry kinase family protein/0.455
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.452
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.451
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.450
3qc9ADPRhodopsin kinase/0.449
3wowANPCasein kinase II subunit alpha2.7.11.10.449
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.448
2pzpACPFibroblast growth factor receptor 2/0.448
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.447
2pmlANPUncharacterized protein/0.447
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.447
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.447
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.445
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
2xyuQ9GEphrin type-A receptor 42.7.10.10.445
4oavACP2-5A-dependent ribonuclease3.1.260.445
3a7jADPSerine/threonine-protein kinase 242.7.11.10.444
4bgg844Activin receptor type-12.7.11.300.443
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.442
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.442
3oom507Activin receptor type-12.7.11.300.441
4i3zADPCyclin-dependent kinase 22.7.11.220.440