sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4nb6	444	Nuclear receptor ROR-gamma

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4nb6	444	Nuclear receptor ROR-gamma	/	1.000
3l0l	HC3	Nuclear receptor ROR-gamma	/	0.542
4nie	NBH	Nuclear receptor ROR-gamma	/	0.501
3kyt	HC2	Nuclear receptor ROR-gamma	/	0.494
1n83	CLR	Nuclear receptor ROR-alpha	/	0.447
2vn0	TDZ	Cytochrome P450 2C8	/	0.444
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.443
2nnh	REA	Cytochrome P450 2C8	/	0.443
3th8	TH9	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.441
4j6b	PLO	Cytochrome P450 monooxygenase	/	0.440