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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mvfSTUCalcium-dependent protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4mvfSTUCalcium-dependent protein kinase 22.7.11.11.000
4jia1K3Tyrosine-protein kinase JAK2/0.530
2yaaATPDeath-associated protein kinase 2/0.524
4grb0XGCasein kinase II subunit alpha2.7.11.10.522
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.509
4e6d0NUTyrosine-protein kinase JAK2/0.509
4hge15VTyrosine-protein kinase JAK2/0.509
4aqc88ATyrosine-protein kinase JAK2/0.505
4bcmT7ZCyclin-dependent kinase 22.7.11.220.504
4eooATPCyclin-dependent kinase 22.7.11.220.504
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.503
3zewSTUEphrin type-B receptor 42.7.10.10.503
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
4o0wADNAurora kinase A2.7.11.10.501
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
3lpbNVBTyrosine-protein kinase JAK2/0.500
2j0m4STFocal adhesion kinase 12.7.10.20.499
3u4uLNHCasein kinase II subunit alpha2.7.11.10.499
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.498
5av2KMPDeath-associated protein kinase 12.7.11.10.498
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
2ckeIQUDeath-associated protein kinase 2/0.493
4dtaADNAPH(2'')-Id/0.493
5dt0SKEAurora kinase A2.7.11.10.492
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.491
2ijmATPFocal adhesion kinase 12.7.10.20.487
3ncz3NCRho-associated protein kinase 12.7.11.10.487
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.487
3my5RFZCyclin-dependent kinase 22.7.11.220.486
3q9xEMOCasein kinase II subunit alpha2.7.11.10.486
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.486
5e8ySTUTGF-beta receptor type-22.7.11.300.486
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.485
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.485
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.485
4hvi19STyrosine-protein kinase JAK32.7.10.20.485
2pvmP29Casein kinase II subunit alpha2.7.11.10.484
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.484
5dpvSKEAurora kinase A2.7.11.10.484
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2j0lANPFocal adhesion kinase 12.7.10.20.482
3lltANPProtein serine/threonine kinase-1/0.482
4i5cC5ITyrosine-protein kinase JAK1/0.482
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.482
2ijmADPFocal adhesion kinase 12.7.10.20.481
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.480
5av3KMPDeath-associated protein kinase 12.7.11.10.480
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.479
4j99ACPFibroblast growth factor receptor 2/0.479
4ix6ADPUncharacterized protein/0.478
4jboWPHAurora kinase A2.7.11.10.478
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.478
2p33J07Mitogen-activated protein kinase 102.7.11.240.477
4anmWULCasein kinase II subunit alpha2.7.11.10.477
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.477
4ysjADPCalmodulin-like domain protein kinase/0.477
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.476
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.476
5l8lADPAurora kinase A2.7.11.10.476
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.475
4g1wG1WMitogen-activated protein kinase 82.7.11.240.475
3i60E86Mitogen-activated protein kinase 12.7.11.240.474
4fv6E57Mitogen-activated protein kinase 12.7.11.240.474
3at4CCKCasein kinase II subunit alpha2.7.11.10.473
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.473
4fv9E71Mitogen-activated protein kinase 12.7.11.240.473
4y93746Tyrosine-protein kinase/0.473
3js2VM1Fibroblast growth factor receptor 1/0.472
4s33ANPMitogen-activated protein kinase 12.7.11.240.472
5dosATPAurora kinase A2.7.11.10.472
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.471
3w2sW2REpidermal growth factor receptor2.7.10.10.471
4aguD15Cyclin-dependent kinase-like 1/0.471
4l9i8PRRhodopsin kinase/0.471
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.471
2v7a627Tyrosine-protein kinase ABL12.7.10.20.470
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.470
3bqr4RBDeath-associated protein kinase 3/0.470
4c3pACPAurora kinase A2.7.11.10.470
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.470
2x9fX9FEphrin type-B receptor 42.7.10.10.469
4dgnLU2Casein kinase II subunit alpha2.7.11.10.469
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.468
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2wouZZFTGF-beta receptor type-12.7.11.300.467
3be9P04Casein kinase II subunit alpha2.7.11.10.467
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.467
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.465
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.465
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.465
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.465
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
2zjwREFCasein kinase II subunit alpha2.7.11.10.464
4s34ANPMitogen-activated protein kinase 12.7.11.240.464
1ztfXYARIO-type serine/threonine-protein kinase Rio12.7.11.10.463
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.463
2xa4AZ5Tyrosine-protein kinase JAK2/0.463
3pxkPXKFocal adhesion kinase 12.7.10.20.463
4qnyANPMitogen activated protein kinase, putative/0.463
1om1IQACasein kinase II subunit alpha2.7.11.10.462
2vu3LZECyclin-dependent kinase 22.7.11.220.462
4f081RSTyrosine-protein kinase JAK2/0.462
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.462
4jbpYPHAurora kinase A2.7.11.10.462
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.462
1m2pHNACasein kinase II subunit alpha2.7.11.10.461
1yvj4STTyrosine-protein kinase JAK32.7.10.20.461
2cciATPCyclin-dependent kinase 22.7.11.220.461
2vv9IM9Cyclin-dependent kinase 22.7.11.220.461
2uzbC75Cyclin-dependent kinase 22.7.11.220.460
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.460
4jajXU1Aurora kinase A2.7.11.10.460
4xlvACPInsulin receptor2.7.10.10.460
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4o0uADNAurora kinase A2.7.11.10.459
1pjkANPCasein kinase II subunit alpha2.7.11.10.457
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.457
4c4f7CEDual specificity protein kinase TTK2.7.12.10.457
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.456
4ehzJAKTyrosine-protein kinase JAK1/0.456
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.456
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
2pvlP55Casein kinase II subunit alpha2.7.11.10.455
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.455
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.455
4k8aK8AFocal adhesion kinase 12.7.10.20.455
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.455
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.454
3gu7ADPDeath-associated protein kinase 12.7.11.10.454
1i44ACPInsulin receptor2.7.10.10.453
1jklANPDeath-associated protein kinase 12.7.11.10.453
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.453
3uvqFS8Mitogen-activated protein kinase 14/0.453
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.453
4dgmAGICasein kinase II subunit alpha2.7.11.10.453
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.452
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.452
2xvdAS6Ephrin type-B receptor 42.7.10.10.452
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.452
4h3qANPMitogen-activated protein kinase 12.7.11.240.452
4j95ACPFibroblast growth factor receptor 2/0.452
4otiMI1Serine/threonine-protein kinase N1/0.452
4qmlANPSerine/threonine-protein kinase 242.7.11.10.452
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.451
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.451
5dnrATPAurora kinase A2.7.11.10.451
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.450
2cjmATPCyclin-dependent kinase 22.7.11.220.449
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.449
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.449
5cvfATPCasein kinase II subunit alpha2.7.11.10.448
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.447
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.447
2uzdC85Cyclin-dependent kinase 22.7.11.220.447
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3iok1P6Tyrosine-protein kinase JAK2/0.447
3k5uPFQAurora kinase A2.7.11.10.447
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4b99R4LMitogen-activated protein kinase 72.7.11.240.447
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.446
3c4xATPRhodopsin kinase/0.446
3cgfJNFMitogen-activated protein kinase 102.7.11.240.446
3r8lZ30Cyclin-dependent kinase 22.7.11.220.446
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.446
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.445
2w4jADPDeath-associated protein kinase 12.7.11.10.444
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.444
4aotGW8Serine/threonine-protein kinase 102.7.11.10.444
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
1qmzATPCyclin-dependent kinase 22.7.11.220.443
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.443
2j7t274Serine/threonine-protein kinase 102.7.11.10.443
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2w05FRTCyclin-dependent kinase 22.7.11.220.443
4btjADPTau-tubulin kinase 12.7.11.10.443
4dt9GMPAPH(2'')-Id/0.443
4gt3ATPMitogen-activated protein kinase 12.7.11.240.443
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.443
1pmn984Mitogen-activated protein kinase 102.7.11.240.442
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2pvhP19Casein kinase II subunit alpha2.7.11.10.442
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.442
3nynSGVG protein-coupled receptor kinase 62.7.11.160.442
3t8oATPRhodopsin kinase/0.442
1k6cMK1Gag-Pol polyprotein3.4.23.160.441
1wvxBD4Death-associated protein kinase 12.7.11.10.441
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.441
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1jkkANPDeath-associated protein kinase 12.7.11.10.440
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2henADPEphrin type-B receptor 22.7.10.10.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
3dfcANPDeath-associated protein kinase 12.7.11.10.440
3nux3NVCyclin-dependent kinase 62.7.11.220.440
3sw719KCyclin-dependent kinase 22.7.11.220.440
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.440
4deeADPAurora kinase A2.7.11.10.440