sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4msg	2C6	Tankyrase-1	2.4.2.30

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4msg	2C6	Tankyrase-1	2.4.2.30	1.000
4n4t	2GV	Tankyrase-1	2.4.2.30	0.572
4n4v	2GY	Tankyrase-1	2.4.2.30	0.563
4mt9	2D6	Tankyrase-1	2.4.2.30	0.548
4li6	1XO	Tankyrase-1	2.4.2.30	0.528
4bfp	SWY	Tankyrase-2	2.4.2.30	0.523
4k4e	K4E	Tankyrase-1	2.4.2.30	0.521
4hyf	1AK	Tankyrase-2	2.4.2.30	0.514
4bj9	UHB	Tankyrase-2	2.4.2.30	0.505
4li7	1XP	Tankyrase-1	2.4.2.30	0.505
4i9i	1DY	Tankyrase-1	2.4.2.30	0.475
4msk	2C8	Tankyrase-1	2.4.2.30	0.458
4pnm	NU1	Tankyrase-2	2.4.2.30	0.452
4k4f	K4F	Tankyrase-1	2.4.2.30	0.446
4tkg	09L	Tankyrase-2	2.4.2.30	0.445
4krs	1SX	Tankyrase-1	2.4.2.30	0.443
3u9y	09L	Tankyrase-2	2.4.2.30	0.440