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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mr61K0Bromodomain-containing protein 2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4mr61K0Bromodomain-containing protein 2/1.000
4uyg73BBromodomain-containing protein 2/0.594
4j1p1K0Bromodomain-containing protein 2/0.583
4mr51K0Bromodomain-containing protein 2/0.553
2yemWSHBromodomain-containing protein 4/0.550
4uyf73BBromodomain-containing protein 2/0.537
2yekEAMBromodomain-containing protein 2/0.533
4flpJQ1Bromodomain testis-specific protein/0.523
4a9oA9OBromodomain-containing protein 2/0.501
4men25KBromodomain-containing protein 4/0.497
4alhA9PBromodomain-containing protein 2/0.495
4bw39BMBromodomain-containing protein 4/0.491
4ogiR78Bromodomain-containing protein 4/0.491
4c67L5SBromodomain-containing protein 4/0.490
4o71CPBBromodomain-containing protein 4/0.489
4mep24YBromodomain-containing protein 4/0.487
4aknS5BBromodomain-containing protein 2/0.486
4py6R78Bromodomain protein, putative/0.485
4c66H4CBromodomain-containing protein 4/0.480
4bjx73BBromodomain-containing protein 4/0.479
4j0r1H2Bromodomain-containing protein 4/0.476
4lrg1XBBromodomain-containing protein 4/0.476
4a9nA9NBromodomain-containing protein 2/0.475
3gwfFADCyclohexanone monooxygenase/0.474
4hxs1A3Bromodomain-containing protein 4/0.473
4lyw21QBromodomain-containing protein 4/0.473
3aqaBYHBromodomain-containing protein 2/0.472
4hxo1A6Bromodomain-containing protein 4/0.471
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.471
4h4m494Gag-Pol polyprotein2.7.7.490.470
4mr41K0Bromodomain-containing protein 4/0.470
4bw1S5BBromodomain-containing protein 4/0.469
4lr61XABromodomain-containing protein 4/0.469
4nyv15ECREB-binding protein/0.469
4o74R78Bromodomain-containing protein 4/0.469
4j0s1H3Bromodomain-containing protein 4/0.467
5ikqJMSProstaglandin G/H synthase 21.14.99.10.467
3vt7VDXVitamin D3 receptor/0.466
4gpj0Q1Bromodomain-containing protein 4/0.466
4qzsJQ1Bromodomain-containing protein 4/0.464
4nr52LLCREB-binding protein/0.463
3w0hW12Vitamin D3 receptor/0.462
4meq25OBromodomain-containing protein 4/0.462
4nqmY1ZBromodomain-containing protein 4/0.462
1ndzFR5Adenosine deaminase3.5.4.40.461
4bw2UTHBromodomain-containing protein 4/0.461
4g1y0VOVitamin D3 receptor A/0.459
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3fu83DMLaccase-11.10.3.20.456
4a9hTVPBromodomain-containing protein 2/0.456
1fmlRTLRetinol dehydratase/0.454
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.454
4rw6494Gag-Pol polyprotein2.7.7.490.453
1poxFADPyruvate oxidase1.2.3.30.452
1ppjANYCytochrome b/0.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
3dokGWJPol protein/0.450
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.450
3a1l2CCCytochrome P450/0.449
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
1nzdUPGDNA beta-glucosyltransferase/0.448
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.448
3c6uM22Gag-Pol polyprotein2.7.7.490.448
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4a9lP9LBromodomain-containing protein 4/0.448
3p6oETGCamphor 5-monooxygenase1.14.15.10.447
4o78SAVBromodomain-containing protein 4/0.447
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.446
3lalKRVGag-Pol polyprotein2.7.7.490.446
3s7a684Dihydrofolate reductase1.5.1.30.446
3vt9YI4Vitamin D3 receptor/0.446
4f3i0S6Bromodomain-containing protein 4/0.446
2wonZZEGag-Pol polyprotein2.7.7.490.445
3mdvCL6Cholesterol 24-hydroxylase/0.445
3t1a5MAGag-Pol polyprotein2.7.7.490.445
3vtcTK3Vitamin D3 receptor/0.445
3d84NDPDihydrofolate reductase1.5.1.30.444
3gobHXXDdmC/0.444
1fm4DXCMajor pollen allergen Bet v 1-L/0.443
3c3dFO12-phospho-L-lactate transferase/0.443
3c6tM14Gag-Pol polyprotein2.7.7.490.443
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
4a8v2ANMajor pollen allergen Bet v 1-J/0.443
4ia3BIVVitamin D3 receptor A/0.443
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.442
4tuvCPZCytochrome P450 1191.140.442
1uy8PU5Heat shock protein HSP 90-alpha/0.441
3p3zP3ZPutative cytochrome P450/0.441
4e960NSBromodomain-containing protein 4/0.441
1x8lOXRRetinol dehydratase/0.440
2q9fC3SCholesterol 24-hydroxylase/0.440
3r8zZ63Cyclin-dependent kinase 22.7.11.220.440
3tamM06Gag-Pol polyprotein2.7.7.490.440
3vt65YIVitamin D3 receptor/0.440
3zkuHCVIsopenicillin N synthase1.21.3.10.440
4i9i1DYTankyrase-12.4.2.300.440