Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.21.000
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.522
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.522
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.507
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.504
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.503
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.502
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.489
4eym0RXMitogen-activated protein kinase 132.7.11.240.485
2qoqANPEphrin type-A receptor 32.7.10.10.481
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.481
2c6eHPMAurora kinase A2.7.11.10.480
4jia1K3Tyrosine-protein kinase JAK2/0.476
3vs1VSATyrosine-protein kinase HCK2.7.10.20.472
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.469
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4gk4L90Ephrin type-A receptor 32.7.10.10.469
4id71G0Activated CDC42 kinase 1/0.467
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.464
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.464
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.463
4qmlANPSerine/threonine-protein kinase 242.7.11.10.462
4j95ACPFibroblast growth factor receptor 2/0.460
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.458
5ap57RODual specificity protein kinase TTK2.7.12.10.458
2qocANPEphrin type-A receptor 32.7.10.10.457
2etm7PYFocal adhesion kinase 12.7.10.20.456
2j0lANPFocal adhesion kinase 12.7.10.20.455
2xvdAS6Ephrin type-B receptor 42.7.10.10.455
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
3w2sW2REpidermal growth factor receptor2.7.10.10.450
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.449
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.448
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.447
5eg3ACPFibroblast growth factor receptor 2/0.447
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.446
2henADPEphrin type-B receptor 22.7.10.10.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.445
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.442
4nka2K7Fibroblast growth factor receptor 1/0.442
4ansVGHALK tyrosine kinase receptor2.7.10.10.441
2x9fX9FEphrin type-B receptor 42.7.10.10.440
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440