Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.638 | |
4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.624 | |
1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.597 | |
1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.594 | |
2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.588 | |
3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.579 | |
3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.566 | |
3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.559 | |
4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.553 | |
1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.537 | |
4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.508 | |
3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.481 | |
1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.471 | |
1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.455 | |
1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 |